DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and age-1

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_496462.2	Gene:	age-1 / 174762	WormBaseID:	WBGene00000090	Length:	1182	Species:	Caenorhabditis elegans

Alignment Length:	1252	Identity:	295/1252 - (23%)
Similarity:	477/1252 - (38%)	Gaps:	353/1252 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   566 IVHPALNTL-------QSTVLAASMGKEQV----KGYGMPVTFTCDIDSVVAQVVAQALASLEGQ 619
            |:||.|.|:       :...|....||..:    :|....:|. |....|::.|....||::...
Worm    41 ILHPQLQTMVEQWQMRERPSLETENGKGSLLLENEGVADIITM-CPFGEVISVVFPWFLANVRTS 104

  Fly   620 VKGTVTD----------------YAVKP----------IGLLEWLAPTSR-LSQLECVHNSFQLE 657
            ::..::|                |:|||          .|.:|.:....: ||:|| :|.:|.:
Worm   105 LEIKLSDFKHQLFELIAPMKWGTYSVKPQDYVFRQLNNFGEIEVIFNDDQPLSKLE-LHGTFPM- 167

  Fly   658 KDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLE 722
                |.|......|        ||.|..:|:  .|                    .|...:||||
Worm   168 ----LFLYQPDGIN--------RDKELMSDI--SH--------------------CLGYSLDKLE 198

  Fly   723 SAAD---------------------GVPGRSVVS-------CSG------VVQAVKAICALLGSI 753
            .:.|                     |:.|.|..:       |.|      :...|||  |.|..
Worm   199 ESLDEELRQFRASLWARTKKTCLTRGLEGTSHYAFPEEQYLCVGESCPKDLESKVKA--AKLSY- 260

  Fly   754 DTMEIARCVADLKRICE-----------------------VEQKKY------------------- 776
             .|...:..|::..:||                       .|.:|.
Worm   261 -QMFWRKRKAEINGVCEKMMKIQIEFNPNETPKSLLHTFLYEMRKLDVYDTDDPADEGWFLQLAG 324

  Fly   777 -STGASNPEI-VSDYG------------------------DYAQVVLRPRSMLEQIKVKCNELRD 815
             :|..:||:: ::.|.                        ||.    ||:.:.|...|:.:|.:
Worm   325 RTTFVTNPDVKLTSYDGVRSELESYRCPGFVVRRQSLVLKDYC----RPKPLYEPHYVRAHERK- 384

  Fly   816 AVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIV---------VCISCLHRPLPNWKFD- 870
                   |..:|..|:.. .||..|.....:....:|..         :..:.:.||:....||
Worm   385 -------LALDVLSVSID-STPKQSKNSDMVMTDFRPTASLKQVSLWDLDANLMIRPVNISGFDF 441

  Fly   871 --DYSLCVQI---VY-GTRLLSKPNVLTCSNDTSGGLFPRLN--FSAW----LTFDQHPICTLPR 923
              |..:.|:|   || ||..|:       |..|:     ::|  |:.|    .|||.: :..:|.
Worm   442 PADVDMYVRIEFSVYVGTLTLA-------SKSTT-----KVNAQFAKWNKEMYTFDLY-MKDMPP 493

  Fly   924 EARLTF-VLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLW---PPM 984
            .|.|:. |||||......|             .|:||.::.|.|::..:..|.:|..||   |..
Worm   494 SAVLSIRVLYGKVKLKSEE-------------FEVGWVNMSLTDWRDELRQGQFLFHLWAPEPTA 545

  Fly   985 TDKMLGPAPAR-GCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPH--------------YD 1034
            ....:|...|| |.:      ..::||:..||||:..|...:......|              |:
Worm   546 NRSRIGENGARIGTN------AAVTIEISSYGGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDYE 604

  Fly  1035 FASLDANLQ--EELLDTAELGYTGATERREVFWEKRLYLQSY-PNALPKVLHAAHSW-DYANLID 1095
            ....|...:  :.|:...|.|.....:.:...|..|.|:|.. |:.|..:...|..| |..|..:
Worm   605 SCIRDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSE 669

  Fly  1096 LHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVD-----FLPQLVQSLKHDT 1155
            |:.:|..|.|.|...:|.||..|..|..:|:.|||.:    |:||..     |:..|:|:||::.
Worm   670 LYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKL----NEQLSPVTFHLFILPLIQALKYEP 730

  Fly  1156 YEGSAMARFLLSKCLESPRFAHHMYWLL---VHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRR 1217
            ...|.:...||::.|...|..|.::|||   :..|.|          .|.:.:|        |||
Worm   731 RAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRD----------CDLKSEE--------YRR 777

  Fly  1218 NKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPT 1282
            ..:::.|.:. ..|:.::....|..|..:||.|:..||...:.:....|...:..:...:....:
Worm   778 ISLLMEAYLR-GNEEHIKIITRQVDMVDELTRISTLVKGMPKDVATMKLRDELRSISHKMENMDS 841

  Fly  1283 CLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDAES---LP---AIFKCGDDLQQDQLTIQL 1341
              ||.|..::..:.:.......|...||.:::...:.:|   ||   .|||.||||:||.|.:|:
Worm   842 --PLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQV 904

  Fly  1342 IRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECG--------LTGSFKDR 1398
            :.:|:.:|.|..:|..:..:..:|.|...|:||:|...:|:.:|||..|        :..||.::
Worm   905 LEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNK 969

  Fly  1399 PIAEWLGKQ--------------NPSPLE-----------YQSAVRNFTLSCAGYSVATYVLGIC 1438
                |:.||              ..:|:|           |..:|..|..||.|||||||::||.
Worm   970 ----WIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIK 1030

  Fly  1439 DRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGG---DKPSTDFHY 1500
            |||:||:||...|..||||||..||..:.....:|||.||:||.....||..|   |..|.:...
Worm  1031 DRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQK 1095

  Fly  1501 FVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNA-VQYVRRALL-PSQSNPEAAATFAKMI 1563
            |..||..|:.::..|.||.:.....|....:|.:::.| :.::::.|. ..:|..||...||.:.
Worm  1096 FKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLFCNGESKEEARKFFAGIY 1160

  Fly  1564 QSSLK-SWFTQFNFFLH 1579
            :.:.. ||.|:.|:..|
Worm  1161 EEAFNGSWSTKTNWLFH 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	30/140 (21%)
		C2A_PI3K_class_II	844..1021	CDD:175979	50/203 (25%)
		PI3Ka_II	1038..1202	CDD:238441	47/175 (27%)
		PI3Kc_II	1235..1583	CDD:270710	113/390 (29%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
age-1	NP_496462.2	PI3K_p85B	98..177	CDD:197539	17/84 (20%)
		PI3K_rbd	241..360	CDD:197540	16/122 (13%)
		C2_PI3K_like	420..574	CDD:176026	48/185 (26%)
		PI3Ka	606..798	CDD:214537	54/214 (25%)
		PKc_like	793..1181	CDD:304357	113/391 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780