Protein Alignment Pi3K68D and vps-34

DIOPT Version :9

• Sequence 1: NP_001163420.1
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_491741.1
• Gene: vps-34 / 172280
• WormBaseID: WBGene00006932
• Length: 901
• Species: Caenorhabditis elegans
• Alignment Length: 985
• Identity: 226/985 - (22%)
• Similarity: 382/985 - (38%)
• Gaps: 275/985 - (27%)

  Fly   769 CEVEQKKYSTGASNPEI-VSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAF 832
            |:::        :|.:: |:::....:.||.|...|.|:..:           :.:|.|..::.:
 Worm    19 CDLQ--------TNVQVKVAEFEGIFRDVLNPVRRLNQLFAE-----------ITVYCNNQQIGY 64

  Fly   833 SVKT-----PDYS---------------TTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQ 877
            .|.|     ||.|               |.||..|.:|:...:.|:.       |:.:|..:...
 Worm    65 PVCTSFHTPPDSSQLARQKLIQKWNEWLTLPIRYSDLSRDAFLHITI-------WEHEDDEIVNN 122

  Fly   878 IVYGTRLL--------SKPNVLTCSNDTSGGLFPRLNFS-----------------AW-----LT 912
            ..:..||:        ||..:|     .||.:..::|.|                 ||     |.
 Worm   123 STFSRRLVAQSKLSMFSKRGIL-----KSGVIDVQMNVSTTPDPFVKQPETWKYSDAWGDEIDLL 182

  Fly   913 FDQHPICTLPREARLTFVLYGKQAASEGEPNADQNGER---------------RQVTTELGWCSI 962
            |.|     :.|::|         ...|..|..|....|               |.|...|...:|
 Worm   183 FKQ-----VTRQSR---------GLVEDVPWLDPFASRRIEMIRAKYKYSSPDRHVFLVLEMAAI 233

  Fly   963 QLFDFKRVMICGP--YLLSLWPPMTDKM-----------LGPAPARGCHPQPDFCPVLSIEVPPY 1014
            :|         ||  |.:..:...|..|           :..|..|.|...|:.......||...
 Worm   234 RL---------GPTFYKVVYYEDETKNMRVSTSVNGGVGIVSACTRYCVADPELLLESLAEVKHS 289

  Fly  1015 G-----GRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSY 1074
            .     ..:|...|::|.......|......||....:.|        .|:|::.|:.|.||:.:
 Worm   290 AMTRRIRDVEDERHRQVKPNKQAKDRLETIVNLPSSQVLT--------REQRDLVWKFRHYLRQF 346

  Fly  1075 PNALPKVLHAAHSWDYANLIDLH-ALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPN- 1137
            |.||.|.|.:. :|.:...:... ||::.|..:....:||||...:....||..:|..:.:..:
 Worm   347 PKALNKYLRSV-NWVHPQEVKTALALMNDWELIEAEDALELLSSAFTHPAVRAYSVSRLLEAASP 410

  Fly  1138 DQLVDFLPQLVQSLKH-------------------------------DTYEGSAM---------- 1161
            :|::.:||||||:||:                               :..||..|
 Worm   411 EQVLLYLPQLVQALKYEQGQQLPEEGNPVPVVSEEEGKIPSVATTPTEELEGRDMTVVTKKEARK 475

  Fly  1162 ------ARFLLSKCLESPRFAHHMYWLL---VHSLPD--DPHNS--------IGAAMVDQEYDES 1207
                  |.||:...|.||:.::::||.|   :.|..:  :.|:.        :..|:|.:....:
 Worm   476 AASGDLATFLIDYALASPKVSNYLYWHLKTEIESTKESKEEHSKMYQNIQDRLMEALVKRPDTRA 540

  Fly  1208 QVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDE 1272
            ||..:   .:.::.:..|:.:..|...:..........:..|:   :..||..:..|.
 Worm   541 QVDSL---HQQQIFVEDLIILMNEAKARGGRLNESKSAEFRTM---LSRAKHMLDLKG------- 592

  Fly  1273 VHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINF--VGPDA-------ESLPAIFKC 1328
            ||         |||.|...::.|.....|:|.|..:|.||:|  :.|:.       |....|||.
 Worm   593 VH---------LPLDPSFRLSSVIPDTASFFKSEMMPAKISFKVLQPNGKADRNIPEEYTVIFKT 648

  Fly  1329 GDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQ------- 1386
            ||||:||||..|::|:::.:....:||||:..:..:.||...|.::.: :::.||.||
 Worm   649 GDDLRQDQLIQQMVRLIDIILKKGQLDLKLTPYLVLSTGVGQGFVQCI-KSKPLRAIQEQYKAHK 712

  Fly  1387 VECGLTGSFKD-RPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTS 1450
            ::| :..:.|: ||      ...|..:| .:.:.|:..|.|||||..|:||:.|||.||::|..:
 Worm   713 MDC-IREAMKELRP------GDGPFGIE-PNVIDNYVRSLAGYSVIMYILGLGDRHLDNLLLCEN 769

  Fly  1451 GHLFHIDFGKFLGDAQMFGNFKRD----RTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNI 1511
            |.|||:|||..||         ||    ..|..|||:|..|: ||.| |..|..||.....|:.|
 Worm   770 GKLFHVDFGFILG---------RDPKPMPPPMKLTSEMVQVM-GGVK-SKQFLEFVQHVDSAYRI 823

  Fly  1512 VRKNADLLLHTLAHMATAGMPGVNS---NAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQ 1573
            :|:::::||:..:.|..||:|.:.:   .|:..:.:.|....|:..|.......|:|||.:....
 Worm   824 LRRHSNVLLNLFSLMLDAGIPDIAAEPDKAIFKIEQRLRLDLSDEAATKHIFTQIESSLNAKMAM 888

  Fly  1574 FNFFLHNLAQ 1583
            .:..:|...|
 Worm   889 ISDIIHAYKQ 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	43/239 (18%)
		PI3Ka_II	1038..1202	CDD:238441	50/225 (22%)
		PI3Kc_II	1235..1583	CDD:270710	108/371 (29%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
vps-34	NP_491741.1	C2_PI3K_class_III	21..193	CDD:176042	38/216 (18%)
		PI3Ka_III	303..509	CDD:238442	49/214 (23%)
		PI3Kc_III	543..898	CDD:270628	110/396 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920