DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and let-363

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_491549.2 Gene:let-363 / 172167 WormBaseID:WBGene00002583 Length:2695 Species:Caenorhabditis elegans


Alignment Length:1386 Identity:280/1386 - (20%)
Similarity:457/1386 - (32%) Gaps:477/1386 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   510 ELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIK---VIVHPAL 571
            ||.||.:.|....|        :||      ..|.:..::....|....||.|.|   .|.|..|
 Worm  1391 ELDSDVQNDLTSCL--------LRA------ISTGIPELIQTILNLAEFMDHSEKGPLPISHDVL 1441

  Fly   572 N--TLQSTVLAASMGKEQV----KGYGMPVTFT---------C----------DIDSVVAQVVAQ 611
            .  ..|:...|.:...:::    |...|..|||         |          ::....|.||..
 Worm  1442 GRWAEQTKAFAKACRYKEMSVLKKSGSMQTTFTRKVKLEPNDCQSLITYANKLNVQEEAAGVVRY 1506

  Fly   612 ALAS-LEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAI 675
            |..: :..|::|             .|.   .:|::.|....:::||:...     |:..|:|..
 Worm  1507 AERNEMNFQMRG-------------RWY---EKLNEWEKALGAYELEEKKK-----SSCPNLQVY 1550

  Fly   676 ARTERDDEHDADLLPEHLLPNEVV--------------------PIVTYDNMMILIETLEMEIDK 720
                  ||.|..:.||.....|..                    .:|..|......:::..||:|
 Worm  1551 ------DEKDHLMTPEEAATAEEARMHEMRCLEALGRWDELNSKSVVWADQRGNRNDSVRDEINK 1609

  Fly   721 -------------------------------LESAADGVPGRSVVS--------CSGVVQAVKAI 746
                                           .|:..||...|:||:        ..|:::.|:.:
 Worm  1610 KQLDHKMAVIAARGAWAVDNWERMADYVSVISENTQDGAMLRAVVAVHNDENTKAMGLIEKVREM 1674

  Fly   747 CALLGSIDTMEIARC----------VADLKRICEVEQK-KYSTGAS-NPEIVSDYGDYAQ----- 794
                  ||:...|..          :..::::.|:|:. :|.|... .|.|...:....|     
 Worm  1675 ------IDSELTAMANESYERAYIPMVSVQQMAELEEAIEYKTRPERRPRIALLWSRRLQGCRRN 1733

  Fly   795 ------------VVLRPRSMLEQIKVKCNEL----------RDAVQELVELYAN----------- 826
                        :||.|:.| ..::||.:.:          |..::||:.|.||           
 Worm  1734 VEQWQRLIMLRGLVLSPQEM-HPLRVKFSSMCRKQGKNSMSRAVLRELLSLPANSDLVRAKAPFD 1797

  Fly   827 ----VFRVAFSVKTPDYS-----------------TTPIPIS--------CVSKPIVVCISCLHR 862
                |..:|..:...|:.                 ..|||.:        ...:|..:|...|.:
 Worm  1798 KPLLVLALAKQLYQDDHKDEAIRALEDLANHWNKRINPIPKATGRELIPPSTKEPARICAKVLLK 1862

  Fly   863 PLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGL-FPRLNFS-AWLTFDQHPICTLPREA 925
             |..|              |.|.||    |.:|...|.| |.|...| .:.|.:.....|:..|.
 Worm  1863 -LGEW--------------TELKSK----TSNNMQVGELSFVRQQVSPQYRTKESRTPETIAFEN 1908

  Fly   926 RLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSI--QLFDFKRVMIC--------------- 973
            .:.:.    |.|::.:|               ||..:  :|.......:|               
 Worm  1909 TINYY----QQATQYDP---------------GWHKVWHKLASTHFYAVCRERPHPTTVISPPQQ 1954

  Fly   974 --GPYLLSLWPPMTDKMLGPAPARGCHPQP----DFCPVLSIEV-----PPYGGRIEFPEHQEVP 1027
              .|..:.: ||:|.....|.||:. .|||    .....||:.:     ||.|..:..|     |
 Worm  1955 PQQPKKMHI-PPVTRATSPPPPAQK-SPQPAPFHSITEPLSVIIDYPVPPPLGSLVGLP-----P 2012

  Fly  1028 KPAPHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYAN 1092
            .||    :.|.:::|..:....:.|.....:...    |.:|||:          ||||:     
 Worm  2013 MPA----YLSSNSSLPPQHHHVSPLSNDSPSNSA----ENKLYLK----------HAAHA----- 2054

  Fly  1093 LIDLHALLHSWAPLSPLQSLELLLPRY------PDAKVREKAVEWISKMPNDQLVDFLPQLVQSL 1151
             :...|.....:|.|.|:....|:..:      .|..|.....|.|..:|....::.:|||:..|
 Worm  2055 -VRCFAKALMCSPGSRLEDTLRLMQLWFDHGDDKDQDVYFALTETIFDLPVTTWLEAIPQLMARL 2118

  Fly  1152 KHDTYEGSAMARFLLSKCLESPRFAHH-----MYWLLVHSLPDDPHNSIGAAMVDQ---EY---- 1204
              |..:.....:.:|....|   .|.|     :|.|.|.|...|.|.|..|..|.:   ||    
 Worm  2119 --DCPDDQKSVQLVLRVLCE---IARHRPQAVIYALTVASRSKDVHRSKNAGTVLEKMMEYHSKL 2178

  Fly  1205 --DESQVTQ--VR-------------------YYRRNKM--MLRAL--MAICGEKMLQRFMYQHR 1242
              :.|.||:  ||                   |:..|.:  |..||  |....:|.....|.:|.
 Worm  2179 VREASLVTEELVRCAILWHEQWHDALDDASRVYFHDNNVQAMFDALRNMNDLMQKGAPTTMKEHS 2243

  Fly  1243 MCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQ-------------DLLEQPTCLPL---GP--- 1288
            ..|   |.:..:|||...::....:..:.:::|             |.|.....|.|   .|   
 Worm  2244 FQQ---TYSSDLKEAGRYVQAFESSGNVKDLNQAWEIYCSVFKKLRDQLATLNSLDLVYVSPNLV 2305

  Fly  1289 -----ELEVTG--------VSVRNCS----YFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQ 1336
                 ||.|.|        ||:::.|    ...|...|.|:...|.:......:.|..:|.:||:
 Worm  2306 SAKDLELVVPGTYDPSAPIVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDE 2370

  Fly  1337 LTIQLIRIMNKMWLAE-----RLDLKMVTFNCVPTGYKSGM-----------------------I 1373
            ..:||..::|.: ||.     |.:|.:..::.|.....||:                       |
 Worm  2371 RVMQLFGLVNTL-LANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKI 2434

  Fly  1374 ELVSEAETLRKIQVECGLTGSFKDRPIAE---------------WLGKQNPSPLEYQSAVRNFTL 1423
            .|..|.:||:|:.:|.......:...:.|               ||  ::||...:.....|:|.
 Worm  2435 PLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWL--KSPSSEVWFDRRTNYTR 2497

  Fly  1424 SCAGYSVATYVLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYV 1487
            |.|..|:..|:||:.|||..|:|| :.:|.:.|||||.....|.:...|. :|.||.||   ..:
 Worm  2498 SVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFP-ERVPFRLT---RML 2558

  Fly  1488 INGGDKPSTD--FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRR------ 1544
            ||..:....|  ::|..:   |...::|.|.:.||..|.  |....|.:|...|:.:::      
 Worm  2559 INAMEVTGLDGVYNYTAE---RVLKMLRTNQESLLAVLE--AFVYDPVINWRLVEGMKKDPKTRK 2618

  Fly  1545 ----------ALLPSQSNPEA 1555
                      |:|||.|..::
 Worm  2619 DTGGRQNMAGAVLPSSSTTDS 2639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674
PI3K_rbd 561..669 CDD:197540 25/136 (18%)
C2A_PI3K_class_II 844..1021 CDD:175979 43/214 (20%)
PI3Ka_II 1038..1202 CDD:238441 38/174 (22%)
PI3Kc_II 1235..1583 CDD:270710 96/419 (23%)
PX_PI3K_C2_68D 1611..1721 CDD:132794
C2B_PI3K_class_II 1751..1871 CDD:176027
let-363NP_491549.2 HEAT repeat 654..683 CDD:293787
TEL1 683..2695 CDD:227365 280/1386 (20%)
HEAT repeat 693..722 CDD:293787
HEAT repeat 731..764 CDD:293787
HEAT repeat 774..805 CDD:293787
HEAT repeat 819..854 CDD:293787
DUF3385 854..1028 CDD:288698
HEAT repeat 863..887 CDD:293787
Extensin_2 1970..2032 CDD:252669 17/71 (24%)
Rapamycin_bind 2188..2286 CDD:285924 17/100 (17%)
PIKKc_TOR 2327..2606 CDD:270713 71/290 (24%)
FATC 2664..2695 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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