DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K68D and BOLA2-SMG1P6

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001307551.1	Gene:	BOLA2-SMG1P6 / 107282092	HGNCID:	53563	Length:	305	Species:	Homo sapiens

Alignment Length:	234	Identity:	47/234 - (20%)
Similarity:	73/234 - (31%)	Gaps:	103/234 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 LGLCLSTAANMQAIARTERDDEHDADLLPEHLLPN--------------------EVVPIVTYDN 706
            ||...|..|.|:..|...| ::...||..||:||:                    .|:..||..|
Human    57 LGCRSSWTAAMELSAEYLR-EKLQRDLEAEHVLPSPGGVGQVRGETAASETQVLYRVMRCVTAAN 120

  Fly   707 MMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEV 771
            .:...|.:      |.:|.:         |.||         ||||:|......|
Human   121 QVFFSEAV------LTAANE---------CVGV---------LLGSLDPSMTIHC---------- 151

  Fly   772 EQKKYSTGASNPEIVSDYG------------DYAQVVLR-------------PRSMLEQIKVKCN 811
                        ::|..||            ||...||.             |.|.:|::.:..:
Human   152 ------------DMVITYGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSS 204

  Fly   812 EL----RDAVQELVELYANVFRVAFSVKTPDYSTTPIPI 846
            :|    ....:|:|.:...|::...|:|.       ||:
Human   205 KLLFLRYHKEKEVVAVAHAVYQAMLSLKN-------IPV 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	3/6 (50%)
		C2A_PI3K_class_II	844..1021	CDD:175979	2/3 (67%)
		PI3Ka_II	1038..1202	CDD:238441
		PI3Kc_II	1235..1583	CDD:270710
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
BOLA2-SMG1P6	NP_001307551.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900