DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K68D and Trrap

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:XP_006504844.1 Gene:Trrap / 100683 MGIID:2153272 Length:3911 Species:Mus musculus


Alignment Length:1975 Identity:351/1975 - (17%)
Similarity:603/1975 - (30%) Gaps:728/1975 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 GSGYQQSSTVAGRDYQAAQRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPT 104
            ||||....|:....|...  :..:|..|:|..:..::::.:..       |:..|::.:    |:
Mouse   362 GSGYTARETLRPLAYSTL--ADLVHHVRQHLPLSDLSLAVQLF-------AKNIDDESL----PS 413

  Fly   105 SKQPESSSPFGKLIEDLQ---RMQPTNPQSALVPMGPVASASIPPQYGFPPHQQRPTAAQPTPYG 166
            |.|..|......|::.::   ..:..|.:..|:.|..|.....   :....:|......:..|..
Mouse   414 SIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKF---HTIARYQLSAIFKKCKPQS 475

  Fly   167 MVAGGVVGGPAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVT 231
            .:      |.|...|..||..|||....|           .||     |||.|......|.|..|
Mouse   476 EL------GAAEAALPGVPTAPAAPGPAP-----------SPA-----PVPAPAPPPPPPPAPAT 518

  Fly   232 PYT-APIVPGSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPS------ 289
            |.| ||:         |.:..||               :.....:||...|.......:      
Mouse   519 PVTPAPV---------PPFEKQG---------------EKDKEDKQTFQVTDCRSLVKTLVCGVK 559

  Fly   290 -----NHSTSSPAEANGVAFPARRQVPSTVGVSSSSHTGNNGHSSVPRRGNDLIDL-------NH 342
                 ..|..:|.||..:  |.::..|....:          :..:.:.....:|:       |.
Mouse   560 TITWGITSCKAPGEAQFI--PNKQLQPKETQI----------YIKLVKYAMQALDIYQVQIAGNG 612

  Fly   343 EDYSRVS------------VLEAFDPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDP 395
            :.|.||:            |||.|                ...:...:|..|.........|   
Mouse   613 QTYIRVANCQTVRMKEEKEVLEHF----------------AGVFTMMNPLTFKEIFQTTVPY--- 658

  Fly   396 MYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGS---------- 450
                      .|..:|.|..|......||:.|:||:....:.......:|.|.||          
Mouse   659 ----------MVERISKNYALQIVANSFLANPTTSALFATILVEYLLERLPEMGSNVELSNLYLK 713

  Fly   451 ------GTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLY 509
                  |::|         ....|:.|...|......:|.:..:.|:..|.|..|..|    .|:
Mouse   714 LFKLVFGSVS---------LFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLR----ALF 765

  Fly   510 ELISDQRTD---------DPELLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIKV 565
            ..|.....|         .|.||:..:|::                    :..:..:|.|..:::
Mouse   766 RSIGGGSHDLLYQEFLPLLPNLLQGLNMLQ--------------------SGLHKQHMKDLFVEL 810

  Fly   566 IVH---------PALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVK 621
            .:.         |.|..|...:::|..|.:                    .:|:|.|.:||..|.
Mouse   811 CLTVPVRLSSLLPYLPMLMDPLVSALNGSQ--------------------TLVSQGLRTLELCVD 855

  Fly   622 GTVTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDA 686
            ....|:      |.:.:.|.                          .|..|||:.||.|:     
Mouse   856 NLQPDF------LYDHIQPV--------------------------RAELMQALWRTLRN----- 883

  Fly   687 DLLPEHLLPNEVVPIVTY--------DNMMILIETLEMEIDKLESAADGVPGRSVV----SCSGV 739
                    |.:.:..|.|        .|..:|.|:     .||......|.|.|:.    .|...
Mouse   884 --------PADSISHVAYRVLGKFGGSNRKMLKES-----QKLHYVVTEVQGPSITVEFSDCKAS 935

  Fly   740 VQ-----AVKAICALLGSIDT--------MEIARCVADLKRICEVEQKKYS----------TGAS 781
            :|     |::.....|.|.:|        .|:.||.  |..:..:|..|::          |..:
Mouse   936 LQLPMEKAIETALDCLKSANTEPYYRRQAWEVIRCF--LVAMMSLEDNKHALYQLLAHPNFTEKT 998

  Fly   782 NPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPI 846
            .|.::..:...||.. ..|...||      .|..|....|            :|....|..|...
Mouse   999 IPNVIISHRYKAQDT-PARKTFEQ------ALTGAFMSAV------------IKDLRPSALPFVA 1044

  Fly   847 SCVSKPIVVCIS--CLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSG--GLFPRLNF 907
            |.:....:|.::  |....||         |.|:.      |:|:.....::.:|  |:.|.:..
Mouse  1045 SLIRHYTMVAVAQQCGPFLLP---------CYQVG------SQPSTAMFHSEENGSKGMDPLVLI 1094

  Fly   908 SA---WLTFDQHPICTLPREAR------LTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQ 963
            .|   .:.:::..:|.:...|.      .:.:|..|:.|                      |.:.
Mouse  1095 DAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERA----------------------CQLP 1137

  Fly   964 LFDF--KRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQE- 1025
            ||.:  :|:..|                       |:.|..:..:        ||.:......| 
Mouse  1138 LFSYIVERLCAC-----------------------CYEQAWYAKL--------GGVVSIKFLMER 1171

  Fly  1026 VPKPAPHYDFASLDANLQEE----------LLD-TAELGYTGATERREVFWEKRLY-----LQSY 1074
            :|          |...||.:          ::| |.|:. .||....:...|:.|.     |:..
Mouse  1172 LP----------LTWVLQNQQTFLKALLFVMMDLTGEVS-NGAVAMAKTTLEQLLMRCATPLKDE 1225

  Fly  1075 PNALPKVLHAAHSWDYANLIDLHALL------HSWAPLSPLQSLELLLPRYPDAKVREKAVEWIS 1133
            ..|...||....|:.:..    |.|:      :|......:.||::|      |:|..|:|..|.
Mouse  1226 ERAEEIVLAQEKSFHHVT----HDLVREVTSPNSTVRKQAMHSLQVL------AQVTGKSVTVIM 1280

  Fly  1134 KMPNDQLVDFLPQLVQSLKHD-------TYEGSAMARFLLSKCLESPRF--------AHHMYWLL 1183
            :...:.|.|.:|.....|:|.       ..||:.....|      .||.        .|.:::..
Mouse  1281 EPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTL------QPRLFTMDLNVVEHKVFYTE 1339

  Fly  1184 VHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHR------ 1242
            :.:|              .|.::|.:|::..|:....::...:|.........::.|.|      
Mouse  1340 LLNL--------------CEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAA 1390

  Fly  1243 MCQKLTTIAESVKEAKESMRQKSLAAG---MDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFN 1304
            :.:.|.:....::||.|:..:|.|...   :|::|..:  :|..:.||.              :.
Mouse  1391 LFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHM--RPLLMMLGD--------------YR 1439

  Fly  1305 SNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYK 1369
            |.||.: :|.:.......|..|       .|:...|:::.:.| |    :::.::|..   .|.:
Mouse  1440 SLTLNV-VNRLTSVTRLFPNSF-------NDKFCDQMMQHLRK-W----MEVVVITHK---GGQR 1488

  Fly  1370 SGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNF--TLSCAGYSVAT 1432
            |...|.:||..       .|.|:...:..|..|.:     ..::..||:.|.  .:..|..::..
Mouse  1489 SDGNESLSECG-------RCSLSPFCQFEPAMEGV-----EEMKICSAIINLFHLIPAAPQTLVK 1541

  Fly  1433 YVLGICDRHNDNIMLKTSGHLFHIDFGKF-----------------LGDAQ---MFGNF--KRDR 1475
            .:|.:..: .:..||..:|..|.....||                 |.|.|   ||.:|  .:|.
Mouse  1542 PLLEVVMK-TERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDA 1605

  Fly  1476 TPF--VLTSD----MAYVINGG-------DKPSTDFHYFVDLCCRAFNIVR---KNADLLL---H 1521
            .|.  ||.::    :..::.||       ..|||. :..:||..:|..|:.   ||.|..|   |
Mouse  1606 RPLRDVLAANPNRFITLLLPGGAQTAVRPGSPSTS-NMRLDLQFQAIKIISIIVKNDDAWLASQH 1669

  Fly  1522 TLAHMATAGMPGVNSNAVQYVRRALLPSQSNPE------AAATFAKMIQSSLKSW-------FTQ 1573
            :|               |..:||..: |::..|      .|||          :|       |..
Mouse  1670 SL---------------VSQLRRVWV-SETFQERHRKENMAAT----------NWKEPKLLAFCL 1708

  Fly  1574 FNFFLHNLAQMRFTPDEGSGELLSFVPRKYTMQQDGRLKIVKVVC---FQKHYSMEKFYMYILEV 1635
            .|:...|.         |..|||..:.|.:|    ||.     :|   |.|.|..|:        
Mouse  1709 LNYCKRNY---------GDIELLFQLLRAFT----GRF-----LCNMTFLKEYMEEE-------- 1747

  Fly  1636 TRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKS 1700
                      :.::|    ...||..:.|..|:.:....|           .|.:..::|..|..
Mouse  1748 ----------IPKNY----SIAQKRALFFRFVEFNDPNFG-----------DELKAKVLQHILNP 1787

  Fly  1701 LFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEIGQIRLS--------- 1756
            .|           :|:|    .:.:.|..||.|       .|..|||..|..:.::         
Mouse  1788 AF-----------LYSF----EKGEGEQLLGPP-------NPEGDNPESITSVFITKVLDPEKQA 1830

  Fly  1757 ----------LQYQRGVLTVMIHHA 1771
                      |||    .|:::.||
Mouse  1831 DMLDSLRIYLLQY----ATLLVEHA 1851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 61/367 (17%)
PI3K_rbd 561..669 CDD:197540 14/116 (12%)
C2A_PI3K_class_II 844..1021 CDD:175979 27/191 (14%)
PI3Ka_II 1038..1202 CDD:238441 38/200 (19%)
PI3Kc_II 1235..1583 CDD:270710 81/412 (20%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 17/112 (15%)
C2B_PI3K_class_II 1751..1871 CDD:176027 6/40 (15%)
TrrapXP_006504844.1 TEL1 <2552..3911 CDD:227365
FAT 2868..3211 CDD:367004
PIKK_TRRAP 3522..3835 CDD:270707
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.