Protein Alignment Pi3K68D and pik3c2g

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_031754263.1
• Gene: pik3c2g / 100496878
• XenbaseID: XB-GENE-22068903
• Length: 1782
• Species: Xenopus tropicalis
• Alignment Length: 1961
• Identity: 490/1961 - (24%)
• Similarity: 742/1961 - (37%)
• Gaps: 532/1961 - (27%)

  Fly     6 HIDYDKQ---FQDDLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVA------------GRDYQ 55
            ||..|..   ||.....|:.::|...:|        ||....||..:|            |..|.
 Frog   162 HIAPDSNTFIFQTQTTNASEVTLRSRSL--------YGHSGHQSVDLAETPTASHYPWESGPPYW 218

  Fly    56 AAQR---------------------SQSLHQPRRHSEVHQVAISPENAER-----SRTPPAQGTD 94
            |.::                     |.|:...|  || :..:.|..|:.|     .|.|...|.:
 Frog   219 ALEKQDWRIRLLDPSGNRDRDFTAFSDSVKSIR--SE-YSASDSESNSGRVWAVAVRFPLGVGAE 280

  Fly    95 ND-------------LIC----------FAS-------PTSKQPESSSPFGKLIEDLQRMQPTNP 129
            :|             |||          |.|       |..:.|.|.:|     :......|.:|
 Frog   281 SDLRVTVCGGCLPHPLICSERDSVRVQDFISKLFRPNFPAPQHPNSPAP-----QHPNSPAPQHP 340

  Fly   130 QSALVPMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVPYQPAAQQQR 194
            .|. .|..|.:.|...|.|..|.|...|....|           ..||....||. |..|.....
 Frog   341 NSP-APQHPNSPAPQHPNYFTPQHPNSPAPQHP-----------NSPAPQAPQLF-YTSAPPTLL 392

  Fly   195 PLNSEELQRLY--SMPA-QMAVVPVPQ-PNAYMYYPGAVVTPYTAPIVPGSAAFMPPQYPAQGYG 255
            .|::..:..|.  :.|| |....|.|| ||:    |......|..|..|.|.|...|..||..:.
 Frog   393 HLSTPTILHLSTPNSPAPQHPNSPAPQHPNS----PAPQHPNYFTPQHPNSPAPQHPNSPAPQHP 453

  Fly   256 FGGAYTHMDLRRPQ--SQPAPQQ---------TAPTTSH-HHSQPSNHSTSSPAEANGVAFPARR 308
            ...|..|.:...||  :.||||.         .:|...| ::.:|.:.::.:|...|.:| |...
 Frog   454 NSPAPQHPNSPAPQHPNSPAPQHPYYPEPQHPNSPAPQHPYYPEPQHPNSPAPQHPNYLA-PQHP 517

  Fly   309 QVPSTVGVSSSSHTGNNGHSSVPRRGNDLIDLN-------HEDYSRVSVLEAFDPLLNDNTGNDT 366
            ..|..          .:.:|..|:..|.|...:       |.:|            |.....|..
 Frog   518 YYPEP----------QHPNSPAPQHPNYLAPQHPNSPAPQHPNY------------LAPQHPNSP 560

  Fly   367 ASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATV--SPNVGLIGWRQDFLSQPST 429
            |....:|.....|           .|.:|.:.:.........:|  :||..:       |.|.|:
 Frog   561 APQHPNYPLPQHP-----------NYPEPQHPSFTLPQHPNYSVPQNPNYPV-------LQQTSS 607

  Fly   430 SSSQYG--VAPPEESLKLAENGSGTISPPPPLPPRNQQCYES--NQAAMPVSRPP---------- 480
            ...|:.  :||...:|            ||..|| .|..|.|  .||::....||
 Frog   608 PVPQHPNYLAPQHPNL------------PPEYPP-VQNIYPSLQPQASLSQQHPPGQRIYPSLPH 659

  Fly   481 QSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPEL--LEFYHMVKEVRARYPHDDAPT 543
            |.|||...||.:........:.......|. .:.|.|...:|  ||.|   .....:||....|:
 Frog   660 QHSVLQQEYTPAQDKYPSQQQYPPAQPTYP-SAPQPTPSQQLYPLEPY---SASPPQYPQSPGPS 720

  Fly   544 -NVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQ 607
             ..|..:.:...|...:........|..|..|:|..|...:..|.      |:..|.:.|
 Frog   721 PPPGGYLLSICGYDEFLQNDFTFRCHLNLQRLESVRLRLHLNPEP------PLARTNEDD----- 774

  Fly   608 VVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANM 672
                     |.:.:..:.|:|      ..|....:||:
 Frog   775 ---------ESEQRMDLLDHA------QYWAQMKNRLT--------------------------- 797

  Fly   673 QAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCS 737
              :|.:...|:..|.|  .|.:|      ||:
 Frog   798 --LALSHYGDQTQAFL--SHKVP------VTH--------------------------------- 819

  Fly   738 GVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSM 802
             |:|:||.||.||..::|.|:...:..|:      ..:| .|| ||      |...||.|:...:
 Frog   820 -VLQSVKEICYLLRGVETKELNVALTALR------HTQY-LGA-NP------GGAPQVSLQSAVL 869

  Fly   803 LEQIKVKCNELRDAVQELVELYANVFRVAFSVKTP--DYSTTPIPISCVSKPIVVCISCLHRPLP 865
                     .:..|:..|:.:|::.|...|.|:.|  .:.:|..|.|.:|    :.:...|....
 Frog   870 ---------GVSGALARLINIYSSSFNADFLVELPRSPHCSTESPESHLS----LHLYSAHNLPD 921

  Fly   866 NW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGG------LFPRLNFSAWLTFDQHPICTLP 922
            ||  :...:||...::|..|.|       |:...|.|      ||..:.:...:|| ..|:..||
 Frog   922 NWVNRIGSFSLSCSVIYAGRRL-------CAEMGSRGAPATQSLFSLVTWDEVITF-PIPVWVLP 978

  Fly   923 REARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLW-----P 982
            .|:.|...|.|           ..||.  ..|..|.|..:.|:...| ::.||.||::.     |
 Frog   979 YESMLVLRLSG-----------INNGS--NTTANLAWSCLPLYSHGR-LVGGPMLLNMISHAEPP 1029

  Fly   983 PMT-----DKMLGPAPARGCHPQPDFCPVL---SIEVPPYGGRIEFPEHQEVPKPAPHYD-FASL 1038
            |:.     ||.|               |.|   .:|:|........|..::||...|..| ..||
 Frog  1030 PVITPGAFDKAL---------------PTLVTVQVELPERNQTFSPPAPEQVPPNVPLEDPSGSL 1079

  Fly  1039 DANLQEE---LLDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALL 1100
            :..:...   ||..|:         ::..|..|...:...|.||.||.:|..||..::..::.:|
 Frog  1080 EILVHRNSVLLLSEAD---------KQYLWNYRSCCKKPRNILPLVLGSAPGWDPPSISAMYRVL 1135

  Fly  1101 HSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFL 1165
            ..|....|.:.|.||...:.|.::||.|...|.|:|||:|:||||||||::|.:....|.:.:.|
 Frog  1136 GDWTFSHPTEGLALLNSSFSDQRIRETACREIGKLPNDELLDFLPQLVQAVKFEWTLDSPLVKLL 1200

  Fly  1166 LSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICG 1230
            |.:.::|.:.||.::|||..: ..:||  .||                .||:   :|.||....|
 Frog  1201 LHRSMQSIQVAHRLFWLLTVA-QTEPH--YGA----------------LYRK---VLAALQFGAG 1243

  Fly  1231 EKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTC-LPLGPELEVTG 1294
            :.:...|..|.|:...|..||..||::.::.||::|.:.:.::.|...|...| ||..|.:.|.|
 Frog  1244 KALNGEFHKQKRLIGLLGGIAGRVKKSPDAKRQETLQSNLHQLEQFFQEVQVCRLPQDPAIIVRG 1308

  Fly  1295 VSVRNCSYFNSNTLPLKINFVGPD--AESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLK 1357
            :....||:|.||..||||:|:..|  .:.:..|||.||||:||.|.:|::.:::::||.|.|||:
 Frog  1309 IDPGACSFFKSNASPLKISFLSADPLGQKINVIFKLGDDLRQDMLVLQIVGLIDRIWLHEGLDLR 1373

  Fly  1358 MVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFT 1422
            |:|:.|:.||...|::::|.:|.||.||....|:.|..||:.|.:|....:|:..:|:.|..||.
 Frog  1374 MITYRCLATGQNQGLVQMVPDATTLAKIHEHSGILGPLKDKSIKKWFKGHHPTQHDYEKAKENFL 1438

  Fly  1423 LSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYV 1487
            .||||:.|.|::||:|||||||||:..|||:||||||||||.||.|||.||||.||:.||:|.|.
 Frog  1439 FSCAGWCVVTFILGVCDRHNDNIMVTNSGHMFHIDFGKFLGHAQKFGNIKRDRAPFIFTSEMEYF 1503

  Fly  1488 INGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMP---GVNSNAVQYVRRALLPS 1549
            |..|.:.......||:|||||:||||:.:.|||..|..|...|:|   ||..  ::|:...|.|.
 Frog  1504 ITDGGRSLDRARDFVELCCRAYNIVRRRSHLLLPLLELMLQGGLPELCGVQD--LRYLHNNLRPQ 1566

  Fly  1550 QSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGELLSFVPRKYTMQQDGRLKIV 1614
            .|:|||.:.|.:....||:.:..:.|..:|..|.|.          ||.|.:..:
 Frog  1567 DSDPEATSYFTRKFGESLQCFPVKLNNLIHTFANMS----------LSDVAKSVS---------- 1611

  Fly  1615 KVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVG 1679
                                                            |..|..    |.| ...
 Frog  1612 ------------------------------------------------HIDLTG----PTG-GAP 1623

  Fly  1680 RSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSR 1744
            |:.||..|...:..|.:             .||.|.|:.....|....:.:|     :.:.:|:
 Frog  1624 RNLIKRAAMASIRKINK-------------QSEKVLTYLGAEGRTGAVSPMG-----DTETRPA- 1669

  Fly  1745 DNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKT 1809
                    ::|.:.|:...|:|:|.|.:.: .|..|..|:..::..|.|||::.:..:.|...|:
 Frog  1670 --------VQLHVSYKNQNLSVLIKHLRNI-HLPDGSAPSADIEVSLLPDPQQTSLIRIKSKGKS 1725

  Fly  1810 CVPSFMETLEY 1820
            ..|...|.:.|
 Frog  1726 ASPIHNELVRY 1736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021	70/309 (23%)
		PI3K_rbd	561..669	CDD:197540	15/107 (14%)
		C2A_PI3K_class_II	844..1021	CDD:175979	45/197 (23%)
		PI3Ka_II	1038..1202	CDD:238441	52/166 (31%)
		PI3Kc_II	1235..1583	CDD:270710	149/353 (42%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	13/109 (12%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	18/70 (26%)
pik3c2g	XP_031754263.1	PHA03247	<304..709	CDD:223021	106/484 (22%)
		C2A_PI3K_class_II	908..1053	CDD:175979	42/185 (23%)
		PI3Ka	1073..1241	CDD:412275	59/198 (30%)
		Protein Kinases, catalytic domain	1247..1599	CDD:473864	149/353 (42%)
		C2	1668..1778	CDD:472691	19/79 (24%)