Protein Alignment Pi3K68D and pik3c3

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_031750800.1
• Gene: pik3c3 / 100485933
• XenbaseID: XB-GENE-6085226
• Length: 887
• Species: Xenopus tropicalis
• Alignment Length: 891
• Identity: 208/891 - (23%)
• Similarity: 335/891 - (37%)
• Gaps: 240/891 - (26%)

  Fly   870 DDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLF-PRLNFSAWLTFDQHPI--CTLPREARLTFVL 931
            |.|..|.....|     ||..|...  ||...| .|.|::.||..   |:  ..|||.|::...:
 Frog    56 DLYVTCQVFAEG-----KPLALPVR--TSYKAFSTRWNWNEWLKL---PVKYADLPRSAQVALTI 110

  Fly   932 YGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPM------------ 984
            :......:..|              :|..::.||....:...|.:.|.:||.:
 Frog   111 WDVYGPGKAIP--------------VGGTTVSLFGKYGMFRQGMHDLKVWPNIEADGSEPTKTPG 161

  Fly   985 -------TDKMLGPAPARGCHPQPDFCPV--------------------------LSIEVP---- 1012
                   .|:|...|.....|.|.....|                          |.:|.|
 Frog   162 RTSSSASEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFPCVKS 226

  Fly  1013 ---PYG-------GRIEFP-----EHQEVPKP---------APHYDFA-SL-----DANLQEELL 1047
               .||       |....|     |...||.|         :.|:..| ||     |.:|:....
 Frog   227 DEKEYGIVYYEKDGDESTPISSSSEIVRVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAA 291

  Fly  1048 DTAELGYTGA--------TERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHA-----L 1099
            ...:|....:        :|.:::.|:.|.||.:...||.|.|... :||    :...|     |
 Frog   292 TRDQLNIIVSYPPTKQLTSEEQDLVWKFRHYLTNQEKALTKFLKCV-NWD----LPQEAKQALEL 351

  Fly  1100 LHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEG------ 1158
            |..|.|:....|||||...:.:..||..||..:.:..::.|:.:|.||||:||::.:|.
 Frog   352 LGKWKPMDVEDSLELLSSHFTNPTVRRYAVARLQQADDEDLLMYLLQLVQALKYENFEDIKSGLE 416

  Fly  1159 ----------------------------------SA----------------------MARFLLS 1167
                                              ||                      :..||:|
 Frog   417 PTKKDSQGPMLESMTTSGINPESDSSQVISNPLPSAVSSPAPSSKTKDGLDAENLEQDLCTFLIS 481

  Fly  1168 KCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYR-------RNKMMLRAL 1225
            :..::...|:::||.::....|.     ...:.|.:..|..:..:|.:.       ::..::|:|
 Frog   482 RACKNSTLANYLYWYVIVECEDQ-----DTQLRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSL 541

  Fly  1226 MAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLE-QPTCLPLGPE 1289
            :| ..:..:.|.::..:..|:     ||....|::.|.::|..  |....:|.| :|..|||.|:
 Frog   542 LA-TQQTFVDRLVHLMKAVQR-----ESGNRKKKNERLQALLG--DNEKMNLSEFEPIPLPLEPQ 598

  Fly  1290 LEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERL 1354
            :::.|:.....:.|.|..:|.|:.|...|....|.|||.||||:||||.:|:|.:|:|:...|.|
 Frog   599 VKIRGIIPEKATLFKSALMPAKLYFKTEDGGRYPVIFKNGDDLRQDQLILQIISLMDKLLRKENL 663

  Fly  1355 DLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPS---PLEYQS 1416
            |||:..:..:.|..|.|.::.:........:..|..:...|:         |..||   |....:
 Frog   664 DLKLTPYKVLATSTKHGFMQFIQSVPVAEVLATEGSIQNFFR---------KYAPSEKGPYGISA 719

  Fly  1417 AVRN-FTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRD----RT 1476
            .|.: :..|||||.|.||:||:.|||.||::|..:|.|||||||..||         ||    ..
 Frog   720 EVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILG---------RDPKPLPP 775

  Fly  1477 PFVLTSDMAYVING-GDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGV---NSN 1537
            |..|..:|   :.| |...|..:..|...|..||..:|:.::|:|:..:.|..|.:|.:   ...
 Frog   776 PMKLNKEM---VEGMGGTQSEQYQAFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDK 837

  Fly  1538 AVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQ 1583
            .|:.|:.......|:.||......:|..|:.:.|......:|..||
 Frog   838 TVKKVQDKFRLDLSDEEAVHYMQTLIDDSVNALFAAVVEQIHKFAQ 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	39/212 (18%)
		PI3Ka_II	1038..1202	CDD:238441	47/243 (19%)
		PI3Kc_II	1235..1583	CDD:270710	106/360 (29%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pik3c3	XP_031750800.1	C2_PI3K_class_III	26..186	CDD:176042	32/153 (21%)
		PI3Ka_III	283..503	CDD:238442	45/224 (20%)
		PI3Kc_III	539..883	CDD:270628	109/372 (29%)