DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and pik3cg

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_012814080.1	Gene:	pik3cg / 100158519	XenbaseID:	XB-GENE-1011009	Length:	1126	Species:	Xenopus tropicalis

Alignment Length:	750	Identity:	233/750 - (31%)
Similarity:	367/750 - (48%)	Gaps:	88/750 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   878 IVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVLY--------GK 934
            |.:|.::||:... ||...|...|     :::||.|| ..|..||:.|.|...::        .|
Frog   403 IQHGQQVLSQRRT-TCKPFTEEVL-----WNSWLEFD-IKIKDLPKGALLNLQIFCGKAPTASNK 460

  Fly   935 QAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARG--- 996
            ......|..|..:..:.|:   |.:.::.|.|.:.::..|.|:|.:|     |:.|....:|
Frog   461 SIVQSPESTASDSKCKNQL---LYYVNLLLIDHRFLLRQGEYVLHMW-----KIPGKGEEQGSIN 517

  Fly   997 -------CHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKP---APHYDFASLDANLQEELLDTAE 1051
                   .:|..:....:||.:..|...:..|:|:.|..|   .|..:..:......||::.|..
Frog   518 ADKLTSATNPDKETSMAISISLDKYCHPVALPKHKLVCDPELERPRTEMPNQLRKQLEEIIATDP 582

  Fly  1052 LGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLI----DLHALLHSW--APLSPLQ 1110
            | :....|.:|:.|..|..:..:|.|.||:|.:. .|....::    .|.:...:|  ..|....
Frog   583 L-HPLTPEDKELLWHFRSEIVKHPEAYPKLLSSV-KWGQQEMVAKTYQLLSKREAWDDCSLDVGL 645

  Fly  1111 SLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRF 1175
            :::||...:.|..||..||:.:..:.:|.::.:|.||||::|.:.|..||::||||.:.|:|.|.
Frog   646 TIQLLDCNFSDENVRAMAVQKLESLQDDDVLHYLLQLVQAVKFEPYHDSALSRFLLKRALQSKRI 710

  Fly  1176 AHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQ-VRYYRRNKMMLRALMAICGEKMLQRFMY 1239
            .|.::|.|                      .|::.| :.|.:|..::|.|.:..||:.||..|..
Frog   711 GHFLFWFL----------------------RSEIAQSMHYQQRFAVILEAYLRGCGKAMLDDFTR 753

  Fly  1240 QHRMCQ---KLTTIAESVKEAK--------ESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVT 1293
            |.::.:   |:|...:||...|        ..:||| |....:....|.|.....:|..|.|...
Frog   754 QVQVTEILHKVTMEIKSVSAEKYDVTSQVITQLRQK-LEKLQNSKLPDKLPDSFRVPYDPGLRAG 817

  Fly  1294 GVSVRNCSYFNSNTLPLKINFVGPDA-----ESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAER 1353
            .:.|..|....|...||.:.|...|.     |::..|||.||||:||.|.:|::|||..:|.||.
Frog   818 SLVVEKCKVMASKKKPLWLEFKCSDTTALSNETIGIIFKHGDDLRQDMLILQILRIMGSIWEAES 882

  Fly  1354 LDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVE-CGLTGSFKDRPIAEWLGKQNPSPLEYQSA 1417
            |||.::.:.|:.||.|.||||:|.:|.|:.:||.. .|.||:|||..:::||.::.|...::.:|
Frog   883 LDLCLLPYGCISTGNKIGMIEIVKDATTIAQIQQSTVGNTGAFKDEVLSQWLKEKCPIEEKFSAA 947

  Fly  1418 VRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTS 1482
            |..|..|||||.|||:||||.||||||||:..||:|||||||..||:.:.|....::|.|||||.
Frog   948 VERFVYSCAGYCVATFVLGIGDRHNDNIMVTESGNLFHIDFGHILGNYKSFLGINKERVPFVLTP 1012

  Fly  1483 DMAYVI-NGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNA-VQYVRRA 1545
            |..||: ..|.|.|..|:.|.|:|.:|:..:|.:.:|::...:.|...|||.:.|.. ::|:|.:
Frog  1013 DFLYVMGTSGKKTSQYFNKFQDVCVKAYLALRHHTNLMIILFSMMLMTGMPQLTSKEDIEYIRDS 1077

  Fly  1546 LLPSQSNPEAAATFAKMIQSSL-KSWFTQFNFFLH 1579
            |...::...|...|...|:... |.|..|||:|||
Frog  1078 LTVGKNEESAKKHFLDQIEVCRDKGWTVQFNWFLH 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	35/160 (22%)
		PI3Ka_II	1038..1202	CDD:238441	44/169 (26%)
		PI3Kc_II	1235..1583	CDD:270710	138/364 (38%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pik3cg	XP_012814080.1	PI3K_rbd	221..328	CDD:413336
		C2_PI3K_class_I_gamma	366..546	CDD:176044	35/157 (22%)
		PI3Ka_I	568..744	CDD:238444	50/199 (25%)
		PI3Kc_IB_gamma	748..1118	CDD:270627	139/365 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010