DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and pik3ca

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_001119972.1 Gene:pik3ca / 100144924 XenbaseID:XB-GENE-998106 Length:1065 Species:Xenopus tropicalis


Alignment Length:1247 Identity:313/1247 - (25%)
Similarity:512/1247 - (41%) Gaps:300/1247 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   455 PPPP----------LPPR-NQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRL 508
            ||.|          :||| ..:|...|...:.:      ..|.::...:|...:..:.||  ..|
 Frog     2 PPRPSSGELWGIHLMPPRILVECLLPNGMVVVL------ECLREATLVNIKHELFKEARK--YPL 58

  Fly   509 YELISDQR-------TDDPELLEFYHMVK---EVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSI 563
            |.|:.|:.       |.:.|..||:...:   ::|...|.                        :
 Frog    59 YHLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPF------------------------L 99

  Fly   564 KVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTV--TD 626
            || |.|..|. :..:|...:|    ...||||   |:.|.|....|.....::....|.:|  .|
 Frog   100 KV-VEPVGNR-EEKILNREIG----FAIGMPV---CEFDMVKDSEVQDFRKNILNVCKDSVELRD 155

  Fly   627 YAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEH------D 685
             |..||....::.|.:       |.:|.:|.|.:...|.......:..:..:..:::.      :
 Frog   156 -ANGPISRALYVYPPN-------VESSSELPKHIESKLDKGQIIVVIWVIVSPNNEKQKYSLKIN 212

  Fly   686 ADLLPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGV---------VQ 741
            .|.:|||:    :...:......:|:.:.::::..||     ..|:.::...|.         :.
 Frog   213 HDCVPEHV----IAEAIRKKTRSMLLSSEQLKLCVLE-----YQGKYILKVCGCDEYLLEKYPLS 268

  Fly   742 AVKAI--CALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLE 804
            ..|.|  |.:||.:..:                                      :::...|:..
 Frog   269 QYKYIRSCIMLGRMPNL--------------------------------------MLMAKDSLYS 295

  Fly   805 QIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYS---TTPIP----------ISCVSKPIVVC 856
            ||.|                 :||.:      |.||   :|..|          :..::..:.:.
 Frog   296 QIPV-----------------DVFTM------PSYSRRISTAAPYMNGEASAKSLWAINSTLRIK 337

  Fly   857 ISCLHRPLPNWK-FDDYSLCVQIVYGTRLLSKPNVLT----CSNDTSGGLFPRLNFSAWLTFDQH 916
            |.|......|.: .|...:...|.:|...|. .||.|    |||       ||.|  .||.:|..
 Frog   338 ILCATYVNVNIRDIDKIYVRTGIYHGVEPLC-DNVNTQRVPCSN-------PRWN--EWLLYDMF 392

  Fly   917 PICTLPREARLTFVL---YGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLL 978
             |..|||.|||...:   .|::.|.|..             ..|.|.:|.|||:...::.|...|
 Frog   393 -IPDLPRAARLCLSICSVKGRKGAKEEH-------------CPLAWGNINLFDYTDTLVSGKMAL 443

  Fly   979 SLWPPM--TDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDAN 1041
            :|||..  .:.:|.|....|.:|..: .|.|.:|...:...::||            |..:::.:
 Frog   444 NLWPVPHGLEDLLNPIGVSGSNPNKE-TPCLELEFDCFSSPVKFP------------DMTAIEDH 495

  Fly  1042 LQEELLDTAELGY----TGATER-------------------------------REVFWEKRLYL 1071
            ..:.|  ..|:||    :|.:.|                               :|..|..|||.
 Frog   496 ANKVL--EREMGYNYSHSGLSNRIVRENEVRESDKEQLKAISNRDPLSEITEQEKEFLWSHRLYC 558

  Fly  1072 QSYPNALPKVLHAAHSWDYA-NLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISK- 1134
            ::.|..|||:|.:. .|:.. ::..::.||..|..:.|.|::|||...|||..||..||..:.| 
 Frog   559 RNIPEILPKLLLSV-KWNCRDDVSQMYCLLKEWPAIRPEQAMELLDFNYPDRIVRSFAVSCLEKY 622

  Fly  1135 MPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAM 1199
            :.:|:|..:|.||||.:|::.|..:.:.||||.|.|.:.|..|..:||    |..:.||.    .
 Frog   623 LTDDKLSQYLIQLVQVMKYEQYLDNHLVRFLLKKALVNQRIGHFFFWL----LKSEMHNK----T 679

  Fly  1200 VDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQK 1264
            |.|.:.              ::|.:....|| ..|:....|....:||..:.:.:|:.|:...||
 Frog   680 VSQRFG--------------LLLESYCRACG-MYLKHLSKQVEAMEKLINLTDILKQEKKDETQK 729

  Fly  1265 SLAAGMDE--VHQDLLE--QPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPD--AESL- 1322
            .....:.|  ...|.::  |....||.|..::..:.:..|...:|...||.:|:..||  :|.| 
 Frog   730 VQMKFLVEQMKRPDFMDALQGFTSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSEMLF 794

  Fly  1323 ---PAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRK 1384
               ..|||.||||:||.||:|:||||..:|..:.|||:|:.:.|:..|...|:||:|..:.|:.:
 Frog   795 LNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQ 859

  Fly  1385 IQVECGLTGS--FKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIML 1447
            ||.:.||.|:  |....:.:||..:|... .|.:|:..||.|||||.|||::|||.||||.|||:
 Frog   860 IQCKGGLKGALQFNSHTLHQWLKDKNKGE-TYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMV 923

  Fly  1448 KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPST---DFHYFVDLCCRAF 1509
            |.:|.|||||||.||...:....:||:|.|||||.|...||:.|.:..|   ||..|.::|.:|:
 Frog   924 KDNGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGIQECTKTRDFERFQEMCYKAY 988

  Fly  1510 NIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQSNPEAAATFAKMIQSSLK-SWFT 1572
            ..:|::|:|.::..:.|..:|||.:.| :.:.|:|:.|...::..||...|.|.:..:.. .|.|
 Frog   989 LAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTT 1053

  Fly  1573 QFNFFLHNLAQM 1584
            :.::..|.:..:
 Frog  1054 KMDWIFHTIKHL 1065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674
PI3K_rbd 561..669 CDD:197540 27/109 (25%)
C2A_PI3K_class_II 844..1021 CDD:175979 48/196 (24%)
PI3Ka_II 1038..1202 CDD:238441 56/200 (28%)
PI3Kc_II 1235..1583 CDD:270710 128/364 (35%)
PX_PI3K_C2_68D 1611..1721 CDD:132794
C2B_PI3K_class_II 1751..1871 CDD:176027
pik3caNP_001119972.1 PI3K_p85B 34..107 CDD:280372 18/105 (17%)
PI3K_rbd 173..292 CDD:295323 18/165 (11%)
C2_PI3K_class_I_alpha 325..484 CDD:176043 47/183 (26%)
PI3Ka_I 525..696 CDD:238444 52/193 (27%)
PI3Kc_IA_alpha 695..1064 CDD:270719 131/370 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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