DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and pik3c2a

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_001128289.1 Gene:pik3c2a / 100038240 XenbaseID:XB-GENE-484563 Length:1690 Species:Xenopus tropicalis


Alignment Length:1954 Identity:632/1954 - (32%)
Similarity:950/1954 - (48%) Gaps:387/1954 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 DLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAAQRSQSLHQPRRHSEVHQVAISPE 80
            ::.|..||.:|..||...|::::.|.| |..:.:.||                            
 Frog    25 EVDKEEALQMEAEALAKLRKDRRQGRG-QGGAFMQGR---------------------------- 60

  Fly    81 NAERSRTPPAQG-TDNDLICFASPTSKQPESSSPFGKLIEDLQRMQPTNPQSAL----------- 133
                 :.|||.| .:.||:.|....:|:..::..|  |..|::::.....:..|           
 Frog    61 -----QKPPASGRQEPDLMVFPESDAKKKNNAETF--LGIDVEKLTDAEMERLLLDDHFDQRKPL 118

  Fly   134 -VPMGPVASASIPPQ-YGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVPYQPAAQQQRPL 196
             :...|||:....|| ||.|..|:    :|..|      |:.|   .|.:.|:|...|:.   |.
 Frog   119 AISQAPVANPRASPQFYGQPSFQR----SQWAP------GIQG---TGTVNLLPSFSASY---PK 167

  Fly   197 NSEELQRLY--SMPAQMAVVPV----PQPNAYMYYPGAVVTPYTAPIVPGSAAFMPPQYPAQGYG 255
            .:...|..|  |:||.....||    |..:.|:.|..|...|:                      
 Frog   168 CAHPFQNGYNASVPAIRRHDPVYLSLPTGSQYVSYQMAARAPF---------------------- 210

  Fly   256 FGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEANGVAFPARRQVPSTVGVSSSS 320
                           ||           ..:..|..:|.||..|.  .|..         ::|:|
 Frog   211 ---------------QP-----------RGNLSSYSNTVSPDMAK--LFDK---------IASTS 238

  Fly   321 HTGNNGHSSVPRRGNDLIDLNHEDYSRVSVLEAFDPLLNDNTGNDTA-SDSTSYYAEYDPFDFLY 384
            ....||.||.                     ||           |.| |:|||            
 Frog   239 EFVKNGRSSA---------------------EA-----------DAAKSESTS------------ 259

  Fly   385 SGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWRQ-DFLSQP---STSSSQY--GV-APPEES 442
               ...|.:|.. :::|::|              |.. |.||:|   ||.||.:  |: |.|.:|
 Frog   260 ---PTVQGADDA-DSINKFD--------------WLDLDPLSKPKVDSTDSSNHAQGIGASPSDS 306

  Fly   443 LKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSYTSSI-PANVV----LDRR 502
             |:.:.....:....|:.      |.|.:..:  :..|..:.:|.|.:.:| |.::.    ..::
 Frog   307 -KVKDPWDAVLLEEKPIK------YSSPEKKL--NGKPSGATVTRSLSLNIRPTHLQQKWDQPQK 362

  Fly   503 KTCTRL---YELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTNVGHV---------VAAEFNY 555
            .:.||:   ..|:.:...||.|:..|...|.::|.::|.....||.|.|         ::||.  
 Frog   363 DSGTRVPAENSLLKELEADDEEVAAFCQEVAKLRKKFPSSRLQTNPGFVLSPVMLQRNLSAEI-- 425

  Fly   556 HYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQV 620
                 .::||.:                   :::|:..|||||||:.|.|..::.|||..:...:
 Frog   426 -----ANVKVSI-------------------EIEGFQQPVTFTCDVSSPVELIIMQALCWVHDDL 466

  Fly   621 KGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLG-LCLSTAANMQAIARTERDDE 683
            ... :..|.:|..|..|.|.....|...|.:....:.:.::.|. ||..|.:  :.:|||..||.
 Frog   467 SQVDIESYILKVCGQEEVLQNKHCLGSHEYIQLCRKWDTEIRLQLLCHGTVS--RDLARTAEDDA 529

  Fly   684 HDADLLPEHL--LPNEVVPIVTYDNMMILIETLEMEID---KLESAADGVPGRSVVSCSGVVQAV 743
            ...| |.:||  :.......:|..::..|::|...::.   |.||.    |.|.|   ..:::.|
 Frog   530 SPVD-LNKHLAVVDRPFKEPITRQSIEELLDTYHEQVSVCLKHESN----PYRLV---EQLIKVV 586

  Fly   744 KAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKV 808
            ::||..:||::|..|...|..|:|...:.:.: |..|| |..:||:............:.|.:.:
 Frog   587 RSICKTVGSVETPAITESVKKLRRAVNLPRSR-SIEAS-PTNLSDHRSPDSARQSDSPLQETLAL 649

  Fly   809 KCNELRDAVQ-----------------ELVELYANVFRVAFSVKTPDYSTTPIP---ISCVSKPI 853
            ...:|.:.:|                 .|.|...:...:.|::    ::...||   :||..|..
 Frog   650 LTTDLHNLLQLHFSSGNSAATAPPGGRPLKEARTSPDHLQFTI----FAAHGIPTGWVSCFEKYY 710

  Fly   854 VVCISCLH------RPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLT 912
            :|| |.:|      :|:.:.|...|.....:|....|:               :||         
 Frog   711 LVC-SLIHNGKDKFKPVQSKKVGTYKSFFYLVKWDELI---------------IFP--------- 750

  Fly   913 FDQHPICTLPREARLTFVLYG-KQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPY 976
               ..|..||.|:.|...||| ....|.|.|:|:   ::|:....||..|:.||.|:|::|.|..
 Frog   751 ---IQISQLPLESILQLTLYGILNPNSGGSPDAN---KQRKGPEMLGRVSLPLFTFRRMLIGGTK 809

  Fly   977 LLSLWPPMTDKMLGPAPA---RGCHPQPDFCPVLSIEVP-PYGGRIEFPEHQEVPKPAPHYDFAS 1037
            ||.||   |....|||||   |..:.....  ||.::.| |....:..|.|.  .|........|
 Frog   810 LLHLW---TSFHTGPAPAGTTRKTNQMQRI--VLQVDFPLPAFDIVYIPPHP--TKSCAWQSIES 867

  Fly  1038 LDANLQEELLD--TAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALL 1100
            ||.:.:..||.  ..|..:..:.|.:...||||.|...:.|:|||:|.:|.:||.|.|.|::||:
 Frog   868 LDKDAKSRLLSLLAKESAFGLSKEEKAFLWEKRYYCLEHRNSLPKILASAPNWDVAYLSDIYALI 932

  Fly  1101 HSWAPLSPLQSLELLLPRYPDAKVREKAVEWISK-MPNDQLVDFLPQLVQSLKHDTYEGSAMARF 1164
            |.|.|::.:.:||||..|:.|.:||..||:|:.: :.:|:|||||||.||:||::.|..:::.||
 Frog   933 HEWPPMTAVSALELLDSRFSDQEVRTVAVKWVEEGLSDDELVDFLPQFVQALKYELYLDNSLVRF 997

  Fly  1165 LLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAIC 1229
            ||::.|.:.|..|::||||..|| :||:..                 .||.|    :|.||:::|
 Frog   998 LLTRALGNIRITHYLYWLLKDSL-NDPYFG-----------------TRYER----ILGALLSVC 1040

  Fly  1230 GEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTC-LPLGPELEVT 1293
            |:.:.:....|.|:.|.|..:||.|::|..|.||..|..||:.| |.|..:..| |||.|.|...
 Frog  1041 GKGLREELEKQTRLTQLLGVVAEKVRQASGSARQVVLQEGMERV-QLLFRKTKCRLPLSPSLVAK 1104

  Fly  1294 GVSVRNCSYFNSNTLPLKINFVGPD--AESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDL 1356
            .::::.||:|:||.:|||:..|..|  .|.:.::||.|:||:||.|.:|:|:||:|:||.|.|||
 Frog  1105 ELNIKACSFFSSNAVPLKVTMVNADPLGEEINSMFKVGEDLRQDMLALQMIKIMDKLWLQEGLDL 1169

  Fly  1357 KMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNF 1421
            :||.|.|:.||...||:|||..|:||||||||.|:||||||:|:||||.|.|||..:|..|..||
 Frog  1170 RMVLFKCLSTGRDRGMVELVLSADTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEDYAKASENF 1234

  Fly  1422 TLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAY 1486
            ..||||..||||||||||||||||||:|:||:||||||||||.|||||:|||||.||||||||||
 Frog  1235 IYSCAGCCVATYVLGICDRHNDNIMLRTTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAY 1299

  Fly  1487 VINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMP---GVNSNAVQYVRRALLP 1548
            |||||:||:..|..||||||:|:|::||:..|.|:.|:.|..:|:|   |:..  ::||..||.|
 Frog  1300 VINGGEKPTRRFQLFVDLCCQAYNLLRKHTSLFLNLLSLMLPSGLPELTGIQD--LKYVHDALQP 1362

  Fly  1549 SQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE-LLSFVPRKYTMQQDGRLK 1612
            ..::.||...|.::|:|||.|..|:||||:||||| ||.....:.| :|||.|:.|:::||||:|
 Frog  1363 QATDTEATIFFTRLIESSLGSVATKFNFFIHNLAQ-RFAGLPSNDEAILSFTPKTYSLKQDGRIK 1426

  Fly  1613 IVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVH 1677
            ...:..:.|.|:.:|:|:|::.|.|.||.:...:||::.||.|.|.||.:.|||.||...|:.|.
 Frog  1427 EATIFTYHKRYNPDKYYIYVVRVVREGQDNSAFIFRTFDEFQELHNKLSILFPLWKLPGFPSKVV 1491

  Fly  1678 VGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQP 1742
            :||::||.||.||...:..:::||..::.|:|..:|:||||||||||.:..  |...|.....:|
 Frog  1492 LGRTHIKEVAAKRKVELNSYIQSLMGSTPEVAECDLIYTFFHPLLRDDKSE--GSDAIVAPLDEP 1554

  Fly  1743 --SRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKV 1805
              |..:....|:|:||:.|:.|.|.:|:.|.|.| :::...:||.|||.||.|||.|.:||||||
 Frog  1555 PLSPTSGRIEGEIKLSVSYRNGTLFIMVMHIKNL-VIEDNTDPNPYVKTYLLPDPHKTSKRKTKV 1618

  Fly  1806 VRKTCVPSFMETLEYR-MPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYR 1869
            .||||.|:|.|.|.|. .....:::|.||::|.|.::|:||..|||..:.|..::|.||.|.||:
 Frog  1619 SRKTCNPTFNEMLVYSGYNKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLNQETVKWYK 1683

  Fly  1870 LGAV 1873
            |..|
 Frog  1684 LTEV 1687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 64/354 (18%)
PI3K_rbd 561..669 CDD:197540 25/109 (23%)
C2A_PI3K_class_II 844..1021 CDD:175979 53/190 (28%)
PI3Ka_II 1038..1202 CDD:238441 66/166 (40%)
PI3Kc_II 1235..1583 CDD:270710 194/353 (55%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 43/109 (39%)
C2B_PI3K_class_II 1751..1871 CDD:176027 55/120 (46%)
pik3c2aNP_001128289.1 PI3K_rbd 426..512 CDD:395642 23/104 (22%)
C2A_PI3K_class_II 679..852 CDD:175979 55/212 (26%)
PI3Ka 870..1040 CDD:412275 70/191 (37%)
PI3Kc_C2_alpha 1045..1397 CDD:270720 194/354 (55%)
PX_PI3K_C2_alpha 1427..1535 CDD:132822 42/107 (39%)
C2B_PI3K_class_II 1564..1685 CDD:176027 55/121 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 296 1.000 Domainoid score I1462
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H20581
Inparanoid 1 1.050 806 1.000 Inparanoid score I481
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0001789
OrthoInspector 1 1.000 - - oto102288
Panther 1 1.100 - - O PTHR10048
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3211
SonicParanoid 1 1.000 - - X2272
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1010.190

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