DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usf1 and Mitf

DIOPT Version :9

Sequence 1:	NP_956590.1	Gene:	usf1 / 393266	ZFINID:	ZDB-GENE-040426-1072	Length:	309	Species:	Danio rerio
Sequence 2:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	379	Identity:	75/379 - (19%)
Similarity:	128/379 - (33%)	Gaps:	130/379 - (34%)

- Green bases have known domain annotations that are detailed below.

Zfish    11 DVSVPVIEEGAVATAEDPSAITTIQSASTFSTDQPIKYL---FKTEGAGGQVGEL---------- 62
            ||...|::...|  .|:|:....||.    ..:|..:||   ||....|....|:
  Fly   271 DVPPQVLQVSTV--LENPTRYHVIQK----QKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTG 329

Zfish    63 --------------------YPPSGQVTYRVIQVADGQLEAQPDGTTAVSVVTGFPATTQPVTQA 107
                                :.....|:.:.|..:|..:...|.|.:.|..     ....|:...
  Fly   330 NLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRC-----DDINPIEPT 389

Zfish   108 VFSQSEGLEGDGTETHYTYYPATISDATAGTMVTGVQA-------------SDALLTQSAPA--- 156
            |...:....|:....|.|   |.:..:.|.:.::..::             |.:|.:.|||.
  Fly   390 VLRPNSHGAGEPENAHRT---AQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPS 451

Zfish   157 -------------------------------GQLYVMMSPQEVLTGANQRSIAPRTQAYNAKSEG 190
                                           .:|.:...||. ||.|...::|
  Fly   452 VSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQN-LTDAEMNALA------------ 503

Zfish   191 PRTSRDEKRRAQHNEVERRRRDKINNWIVQLSKTIP---DCTIDSTK-TGQSKGGILSKACDYIQ 251
                :|.:::..||.:|||||..||:.|.:|...:|   |...:..: ...:||.||..:.|||:
  Fly   504 ----KDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIK 564

Zfish   252 ELRQSNSRLGDELNSIERLRMDNQLLRQEVE----DWKSKNQILRNQLRQHGIV 301
            .|:          :.:.||| .|:|.:::||    ...|:.:.|..|.:.|||:
  Fly   565 CLK----------HEVTRLR-QNELRQRQVELQNRKLMSRIKELEMQAKSHGIL 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usf1	NP_956590.1	HLH	199..254	CDD:278439	20/58 (34%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	12/44 (27%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	22/74 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840