DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc68D and CG7248

DIOPT Version :9

Sequence 1:	NP_648504.2	Gene:	Muc68D / 39326	FlyBaseID:	FBgn0036203	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_648530.1	Gene:	CG7248 / 39356	FlyBaseID:	FBgn0036229	Length:	796	Species:	Drosophila melanogaster

Alignment Length:	768	Identity:	174/768 - (22%)
Similarity:	266/768 - (34%)	Gaps:	166/768 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 STEGPLSTE----------SSTEGSNESSSTESSQDSTTQESSSS--TESPLSTEPSTEANES-S 931
            |.:||.|..          |.::.::......|.|:||..||.|:  .|.|.:........:| :
  Fly    23 SIKGPSSVGWNNVNQNVILSFSKRNSHECVVSSQQNSTYCESLSNGFYEYPYNCSAYITCYDSCA 87

  Fly   932 STESSQDSTTQESS---SSTEG-------PLSTESSTEANESSSTESSQDSTTQESSSS-TEGPL 985
            ..|...|.....|.   ..|.|       |..|.|.||:...:....::::|...|:.: .|..|
  Fly    88 DLEYCPDGKLFNSPLQICDTPGAVDCEPLPYPTPSPTESPPENPCLGTRNNTLLPSAENCNEFYL 152

  Fly   986 STESSTE-----GS---NESSSTESSQDSTTQESSSSTESPLSTEPSTEANESSSTESSQDSTT- 1041
            .....::     |.   |...:....:|:.......:|..||.|  :|.|.||.:....|:..|
  Fly   153 CVNDQSKVYRCPGEMLFNPDLNICDDKDNVWCYGDRTTPDPLDT--TTPAEESFTKCEDQEKGTF 215

  Fly  1042 -------QE------SSSST-------------EGPLSTESSTEASNESSSTESSQDSTTQESSS 1080
                   |:      :.|.|             .|....:.:.:|..|::.|.:   .|...|||
  Fly   216 FPDPENCQQYYYCWGNKSYTILPCPVDNWFNPISGNCGPDIAPDACRETTPTST---PTIDTSSS 277

  Fly  1081 STEGPLSTESSTE---VTQEPSPTESLPNSSTQGTPCTTDNPSSLEPSPSTPGNDDDSGNSGSEN 1142
            :|..|.|||.|..   ..||...:..:.:.......|..:..|:....||....|..:|:.|...
  Fly   278 TTVAPTSTEDSVGNPCADQELGASFPIKSDCQSYLLCLNNGESTTAKCPSNAWFDPKTGDCGPNV 342

  Fly  1143 GNSS------TSGSPCTTDNPSDPESSSSTPGNDDDSGNS-----GSEN-----GNSSTSGSPCT 1191
            ..::      |:.:..||..|.||.:       |.:.|.|     ..:.     ||..::.:.|.
  Fly   343 SPTACLESFETTTTAVTTQAPKDPCA-------DQELGTSYPLVTNCQQYILCMGNGESTVANCI 400

  Fly  1192 TDNPSDPESSSSTPGNDDDSGNSGSESGITSTTGAPYTTDNPAS--QEPSPSAPENPGDSGNSSS 1254
            .::..||::.:..|   |.|..:..|||:  ||.:|.||....|  ..|||:....|..:...::
  Fly   401 YNSWFDPQTGNCGP---DVSPTACKESGV--TTASPTTTSQATSPLTTPSPTWSTLPTANTEETT 460

  Fly  1255 ESPPEGATPCTPNA-------PKKSTTSSYTAHPTP--KYTTEG---NKA--------------- 1292
            .:||:....|:..:       |:........|.|.|  .|..|.   |:|
  Fly   461 TNPPDIVGICSGESDGYYATYPEVCNKYILCASPVPIAFYCPESLFFNEALQRCVEWESSDCSNG 525

  Fly  1293 ETSTLKSPTGTTPGHQEDRTDCSNMPNGIFLRDFQSCNKYYVCLNGKA-IAGHCPRNLHFDIKRK 1356
            ||:| .||..|||  ..|...||| ..|:.|...::|..|..|.:..: :.|.|....:||....
  Fly   526 ETTT-SSPGFTTP--SPDTQICSN-STGLNLPYQENCQWYIYCTDENSYMMGICGSEEYFDPWTG 586

  Fly  1357 VCNF--------------PSLVDCPLDEAPENVTKKPSDTESTPD-CKSLRNGAYVRDPKSCSRF 1406
            .|.|              |::.|.  .|.|..|. .||...|.|| |.....|..|..|..||:|
  Fly   587 KCGFGVSPEACREIQTTSPTVTDS--TEGPTTVI-TPSTPGSEPDPCDGAPEGKLVPYPDDCSKF 648

  Fly  1407 YVCANGRAIPRQCPQGLHFDIKSNFCNYPILVQCSLEESQADAHGALLAEGVPDCTKVKE----- 1466
            ..|.....|...|.:|..|......|..|....||:..:      .:....:|..|...|
  Fly   649 IQCIQPDPIVYDCREGQEFSAALERCMAPWFANCSIPAT------TIPPVTIPTTTTTTEKPSPN 707

  Fly  1467 ----DTRFGDVKQH----NKYYVCLKGKAVLHYCSPGNWFDLRSQKCIDQRLA 1511
                |...|.:..:    :||..|.....|.:.|..|..|:.....|.|..||
  Fly   708 GICADKAEGSLVPYPGNCSKYIACEDPIPVGYACPEGEEFNPIILTCTDPHLA 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68D	NP_648504.2	ChtBD2	21..69	CDD:214696
		PHA03249	1088..>1209	CDD:223023	27/139 (19%)
		CBM_14	1314..1366	CDD:279884	15/66 (23%)
		CBM_14	1388..1440	CDD:279884	14/51 (27%)
		ChtBD2	1459..1505	CDD:214696	12/58 (21%)
CG7248	NP_648530.1	CBM_14	62..113	CDD:279884	11/50 (22%)
		CBM_14	136..182	CDD:279884	7/45 (16%)
		CBM_14	207..261	CDD:279884	6/53 (11%)
		CBM_14	293..347	CDD:279884	9/53 (17%)
		CBM_14	367..421	CDD:279884	11/63 (17%)
		CBM_14	470..522	CDD:279884	9/51 (18%)
		CBM_14	544..597	CDD:279884	14/53 (26%)
		CBM_14	630..678	CDD:279884	13/47 (28%)
		CBM_14	710..758	CDD:279884	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D33909at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020