DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc68D and CG4835

DIOPT Version :9

Sequence 1:	NP_648504.2	Gene:	Muc68D / 39326	FlyBaseID:	FBgn0036203	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_647965.3	Gene:	CG4835 / 38619	FlyBaseID:	FBgn0035607	Length:	1224	Species:	Drosophila melanogaster

Alignment Length:	1364	Identity:	292/1364 - (21%)
Similarity:	502/1364 - (36%)	Gaps:	379/1364 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVRVLWAF---LWILPKALGKD-------------FCAGQSFGSRAVDSEDPQSYYLCLGFIG 49
            ::|:.|.|::   :..|||...:.             .|.|:.||: .|...|..|.:|....:.
  Fly    13 LVVIAVFWSWQLNVLALPKIEPRHETCNNEQRYENQVMCEGKDFGA-LVPYPDNCSLFLVCDCLY 76

  Fly    50 PIKNTCKNGYLFDAQSQGCVIMNNATQSIKKSNDHKKEVTIKQNISVDRPLIFNIFGNFNFFASL 114
            |....|.....:|.::|.|    |..|:::         .|..:|....|    ..|...|....
  Fly    77 PTVKLCPANLWWDNKTQQC----NYPQAVE---------CIYYSIETPEP----TDGTTRFTPEP 124

  Fly   115 WGNSHETTPSPLKPNPIAHFQFINSAVGIEPLSQDNLADKDKKDIISSSSDSSPTEDATYSSTQV 179
            ..::.:.||.|.:|                                .||:....||..|.:||::
  Fly   125 TSSTQKITPEPTEP--------------------------------PSSTAKITTESTTGTSTEI 157

  Fly   180 SSTQVPEDASSAESIQESTTQG-----SRSSTDISL-----STEASLD----------------- 217
            :|:.......::.........|     .|:..|.|:     ..:|.::
  Fly   158 TSSTPSSYLPTSSWDPPPAPPGISDDYCRNKEDGSVHYYPYDCQAYINCTYGWPVLNYCIEDKVF 222

  Fly   218 ----------DIILSSESIVPTESSTTIISSSTEGSWESHISTDSSIGSKVESLLIEALYSLIQE 272
                      |:....|..:||.::....:|:||        .|...|...|.  ||..| .:.:
  Fly   223 NKYLGICDTPDMADCEELPLPTTTTEMPPTSTTE--------EDVVCGPTPEG--IEEDY-CVPK 276

  Fly   273 SSSSSESPVSNEP----STGATD--------------------DSSSTESLPDSTQESSSSSESP 313
            .:...|.|.:...    ..|.||                    ||...:.||..|...:::..:.
  Fly   277 GNGFYEYPYNCSGYLACKNGCTDLDYCQPDKLFNNWLHICDTPDSVRCDPLPFPTTPGTTNKPTT 341

  Fly   314 VSFELSTEATNESSSSESLPN--SSTQDSSSSTETSFQTE-------STTDATDESSSTE----- 364
            .|...:...|...|:..:||:  |:|:..||:||....|.       ...|..||...|.
  Fly   342 PSVTTTPSITTTPSTPTTLPSDGSTTEIHSSTTEEIVTTTDGLPSDVDPNDCKDEKDGTIFAYIG 406

  Fly   365 -------------------------------SQPDSTTQESSSSTEGPLSTESSTAVTDQSSSTE 398
                                           .:||........:|. |:.|...|..|::::.|.
  Fly   407 NCSEYLICKDNQVQMGHCPPNTLFNPDLLVCDEPDDVVCLGDRTTT-PIPTTIPTTTTEKTTPTT 470

  Fly   399 SSQDSTT----------QESSSS-------------------TEGPLSTESSTEATNESSSTESS 434
            ::....|          ||..:|                   |..|....|..:.:......:.:
  Fly   471 TTTTVATTLGPDQLCDGQELGASFSYPDDCSKYYLCLGGGQWTLAPCIYGSYFDPSTGQCGPDVA 535

  Fly   435 QDSTTQESSSSTEGPLSTESSTEATNESSSTESSQDSTTQESSSSTEGPLSTESSTEATNESSST 499
            .|:......::|    :|.::||.|....:|.....:||.|.:::|..|.:........||:.
  Fly   536 PDACKPSQVTTT----TTTTTTETTTTERNTTPKSTATTTERTTTTVAPKTGICGGRNENENI-- 594

  Fly   500 ESSQDSTTQESSSSSEGPLS------TESSTEATN-----ESSSTESSQDSTTQESSSSTESPLS 553
             :..::.|:.....|..|::      |..|::...     :.|..|..|.:||.|...:...|
  Fly   595 -AYPNNCTKYIVCVSPIPIAFFCPDGTFFSSKLEKCIDDWDESDCEGDQSTTTLEPGYTRPPP-- 656

  Fly   554 TEPSTEANESSSTESSQDST------------TQESSSSTE--DPLSTESSTEATNESSSTESSQ 604
             ||:...|.|..|....|:.            ..:..:..|  ||::.:...:..:::...:.:
  Fly   657 -EPTMCTNSSRDTFPYPDNCQWFIRCVDDYIYMMDVCNCGEYYDPITEKCGADVPSDACRWDYT- 719

  Fly   605 DSTTQESSSSTEGPLSTESSTEGSNESSSTESSQDSTTQKSSS------STESPLSTEPSTEANE 663
             |||    |:|..|.:|.:.|....:....:..:|.......:      ..:.|::.....|..:
  Fly   720 -STT----STTSEPTTTTAVTRPPPQKGPCDDVEDGALVAYPNDCSKYIQCDRPIAVAFECEKGD 779

  Fly   664 SSSTE----------SSQDSTTQESSSSTEGPLSTEPST---EANESSSTESSQDSTTQESSSSS 715
            ..|.|          :...:||.:.|.||..|...|.||   |.:..||||||.:|||:.
  Fly   780 EFSVELGKCVDASLANCSITTTAKPSESTTTPRDGEGSTTPSEPSTGSSTESSTESTTEP----- 839

  Fly   716 EGPLSTESSTEANESSSTESSQDSTTQESSSSTESPLSTEPSTEANESSSTESSQDSTTQESSSS 780
                ||||:||:...|:|||:.:|:|.:|:.:|||  ||..||:.:||.||.|:..|:|
  Fly   840 ----STESTTESTTESTTESTTESSTGQSTETTES--STVLSTDTSESPSTISTPPSST------ 892

  Fly   781 TEGPLSTEPSTEANESSSTESSQDSTTQESSSSSEGPLSTESSTEANESSSTESSQDSTTQESSS 845
                 :.||.|...|:|:||...|...:..:..|..|.....|.............|.......|
  Fly   893 -----TMEPGTTNPEASTTEKPADGICEGKTDDSLVPYPRNCSKYIKCQYPIPVGYDCPDGLEFS 952

  Fly   846 STE----DPLSTESSTEATYESSSTESSQDSTTQESSSSTEGPLSTESSTEGSNESSSTESS--- 903
            .||    ||.....||:.|....:|.|::.|:|         |::|.|:|.   |:::||.|
  Fly   953 PTELTCMDPELAGCSTKLTTPGLTTLSTEASST---------PVTTVSTTP---EATTTEMSTTP 1005

  Fly   904 QDSTTQESSSSTESPLSTEPSTEANESSSTESSQDSTTQESSSSTEGPLSTESSTEANESSSTES 968
            :.:||:.::.||.:..||.|.|...||::::    :||.||:..:..|.:||.:|.  ::::|||
  Fly  1006 KTTTTESTTISTTTTDSTTPQTTTTESTTSK----TTTTESTIISTTPTTTEPTTP--KTTTTES 1064

  Fly   969 SQ-DSTTQESSSSTEGPLSTESSTEGSNESSSTESSQDSTTQESSSSTESPLSTEPSTEANESSS 1032
            :. .:||.||:::|..|           ::::|||:..|||.:::::..:.:||.|:|
  Fly  1065 TTIPTTTTESTTATTTP-----------QTTTTESTTISTTPKTTTTESTTVSTTPTT------- 1111

  Fly  1033 TESSQDSTTQESSSSTEGPLSTESSTEASN-ESSSTESSQDSTTQESSSSTEGPLSTESSTEVTQ 1096
            |||:..|||         |.:||.:|.::. ::::|||:..:||.||:::...|.:.:..|
  Fly  1112 TESTTISTT---------PTTTEPTTVSTTPKTTTTESTTVTTTTESTTTVSTPTTLDPYT---- 1163

  Fly  1097 EPSPTESLPNSSTQGTPCTTDNPSSLEPSPSTPGN------------DDDSGNSGSENGNSSTS 1148
                    ||.      |......:|.|.|:..|.            |.|.|....:|....||
  Fly  1164 --------PNI------CCGQALGTLLPYPNDCGRYVVCDYPIPYAVDCDEGTIFDDNLLQCTS 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68D	NP_648504.2	ChtBD2	21..69	CDD:214696	12/60 (20%)
		PHA03249	1088..>1209	CDD:223023	14/73 (19%)
		CBM_14	1314..1366	CDD:279884
		CBM_14	1388..1440	CDD:279884
		ChtBD2	1459..1505	CDD:214696
CG4835	NP_647965.3	CBM_14	51..103	CDD:279884	15/65 (23%)
		CBM_14	185..237	CDD:279884	5/51 (10%)
		CBM_14	273..322	CDD:279884	6/48 (13%)
		CBM_14	393..444	CDD:279884	5/50 (10%)
		CBM_14	485..539	CDD:279884	7/53 (13%)
		CBM_14	585..638	CDD:279884	8/55 (15%)
		CBM_14	661..714	CDD:279884	7/52 (13%)
		CBM_14	744..796	CDD:279884	5/51 (10%)
		CBM_14	914..962	CDD:279884	8/47 (17%)
		CBM_14	1175..1212	CDD:279884	8/36 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D33909at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020