DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc68D and C39D10.7

DIOPT Version :9

Sequence 1:	NP_648504.2	Gene:	Muc68D / 39326	FlyBaseID:	FBgn0036203	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_509334.3	Gene:	C39D10.7 / 181050	WormBaseID:	WBGene00016534	Length:	1171	Species:	Caenorhabditis elegans

Alignment Length:	876	Identity:	181/876 - (20%)
Similarity:	300/876 - (34%)	Gaps:	212/876 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   784 PLSTEPSTEANESSSTESSQDSTTQESSSSSEGPLSTESSTEANESSSTESSQDSTTQESSSSTE 848
            |.|.:...|.|.|.::..:..:||..||..|......:.:..|..|:...|...:|....|:|..
Worm   236 PESVKDCPEYNGSETSYRAPKTTTSSSSYGSIAEAPVDPTPYAPASAPVYSPPRTTYVPRSTSAA 300

  Fly   849 DP-LSTESSTEATY-ESSSTESSQDSTTQESSSSTEGPLSTESSTEGSNESSSTESSQDS----- 906
            .| ...::.|.|.| .:.:|.|...|:|...:.:..|.........|..|..::..|.|:
Worm   301 PPNPPPQNPTAAPYVPTEATPSPVFSSTVRYNPAVHGDCKNRDGIFGIKECHASFLSCDNGVGRV 365

  Fly   907 ---------TTQESS------------------------SSTESPLSTEPSTEANESSSTESSQD 938
                     .|:.|:                        :..|.|...:...:.....:.:..::
Worm   366 IQCADNLVFDTRVSACEFAAICLEPRKPEDVPVLYNHGGAYNERPAEVKVDFDCTGKPNGKYIKE 430

  Fly   939 STTQE---------SSSSTEGPLSTESST------EANESSSTESSQDSTTQESSSSTEGPLST- 987
            :.|:.         .::...|.|....:|      |..|.:..|.||....:::.::|.|..|:
Worm   431 ACTKSFFTCHDGRAFANDCPGDLVFNKATGTCDFAENCEKNYMEPSQIYKGEDTPTTTIGYSSSV 495

  Fly   988 -ESSTEGSNESSSTESSQDSTTQESSSSTESPLSTE-PSTEANESSSTESSQDSTTQESSSSTEG 1050
             .::||.......|:..:|  |:..|:....|:.|: |:|...|.           .:::.:|:.
Worm   496 VYTTTEQPATKPYTQPPRD--TERPSTIYGRPIYTKAPTTVGYEQ-----------PKATYTTQA 547

  Fly  1051 PLSTESSTE--------ASNESSS--------TESSQDSTTQESSSSTEGPLSTES--STEVTQ- 1096
            |::|..:.:        ..|.:|.        ..:.|...|...::....|...|.  ||.|..
Worm   548 PVTTTIALDDFSCKHLADGNHASGLCKSVFYICANGQVVATTCPANLIFNPYVGECDYSTNVRDC 612

  Fly  1097 ---EP--SPTESLPNSSTQ--GTPCTTDNPSSLEPSPSTPGNDDDSGNSGSENGNSSTSGSPCTT 1154
               :|  :|:.|.|.::::  ..|.||...:.:|.:|.|||           .....||....||
Worm   613 QGYQPTTTPSYSYPKTTSKPYEQPSTTQGYAPIEYTPVTPG-----------YAPQYTSTIFTTT 666

  Fly  1155 DNPSDPESSSSTPGNDDDSGNSGSENG-------NSSTSGSPCTT--------------DN---- 1194
               ..|:.::.....||  ||.|.:..       |..|...||.:              :|
Worm   667 ---LSPKYAAMCAKRDD--GNYGFDCEKYLIKCYNRKTFKFPCPSGLYYSRLQDKCDVKENVEGC 726

  Fly  1195 PSDPESSSSTPGNDDDSGNSGSESGITSTTGAPYTTDNPASQEPSPSAP------ENPGDSG--- 1250
            |....::.:||..:... .|....|.:.:|...|   ||:...|||...      || |:.|
Worm   727 PEYKPTTDATPAAEQPV-ISYQNYGYSQSTTKAY---NPSVTTPSPQHAAFCERLEN-GNYGLDC 786

  Fly  1251 -----------NSSSESP--------------PEGATPCTPNAPKKSTTSSYTAHPTPKYTTEG- 1289
                       .:.:..|              .|....|....|..|||.:.....|.||||..
Worm   787 EDYYISCNNFETTINRCPAGLFYSKLNNRCDYKEHVEDCPEYKPTPSTTPAAEQPGTTKYTTYNY 851

  Fly  1290 -NKAETSTLKSPTGTTPGHQEDRTDCSNMPNGIFLRDFQSCNKYYV-CLNGKAIAGHCPRNLHFD 1352
             |...|||...|..|||  ......||..|:||:...:  |::.|| |:.|:::...|...|.::
Worm   852 PNIDYTSTTPGPVDTTP--LAKAFSCSGRPDGIYALPY--CSQDYVQCMQGRSLISSCAPGLFYN 912

  Fly  1353 IKRKVCNFPSLVD-CPLDEAPENVTKKPSDTESTPDCKSLRNGAYVRDPKSCSRFYV-CANGRAI 1415
            .|..:|.:...|| |.:.        |.||...:..|....:|.|   ...||.:|. |.:.:..
Worm   913 EKNGMCAYKHTVDTCKIG--------KGSDIIDSNACFGKSDGYY---SAGCSSYYFSCIDEQIR 966

  Fly  1416 PRQCPQGLHFDIKSNFCNYPI-LVQCSLEESQADAHGALLAEGVPDCTKVKEDTRFGDVKQHNK- 1478
            ...||..|.|..:|..|.:|| ..:||:         |...:..|........|...:...|.|
Worm   967 KMSCPNSLKFSKESEKCVFPIDAKECSI---------ATTLDRTPPAVPSDFCTIRSNGLHHLKM 1022

  Fly  1479 ----YYVCLKGKAVLHYCSPGNWFDLRSQKC 1505
                |.||..|:|....|.....::..:|.|
Worm  1023 CSPHYIVCDNGRAFSGTCIAPLVYNGDTQTC 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68D	NP_648504.2	ChtBD2	21..69	CDD:214696
		PHA03249	1088..>1209	CDD:223023	34/155 (22%)
		CBM_14	1314..1366	CDD:279884	16/53 (30%)
		CBM_14	1388..1440	CDD:279884	15/53 (28%)
		ChtBD2	1459..1505	CDD:214696	11/50 (22%)
C39D10.7	NP_509334.3	CBM_14	29..79	CDD:279884
		CBM_14	98..148	CDD:279884
		CBM_14	189..242	CDD:279884	2/5 (40%)
		ChtBD2	337..384	CDD:214696	7/46 (15%)
		CBM_14	419..467	CDD:279884	4/47 (9%)
		CBM_14	560..612	CDD:279884	9/51 (18%)
		CBM_14	675..726	CDD:279884	10/52 (19%)
		CBM_14	774..825	CDD:279884	6/51 (12%)
		CBM_14	875..927	CDD:279884	16/53 (30%)
		CBM_14	941..992	CDD:279884	15/53 (28%)
		CBM_14	1010..1062	CDD:279884	11/44 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D487374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109854
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820