DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc68D and cbd-1

DIOPT Version :9

Sequence 1:	NP_648504.2	Gene:	Muc68D / 39326	FlyBaseID:	FBgn0036203	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_502145.2	Gene:	cbd-1 / 178061	WormBaseID:	WBGene00010351	Length:	1319	Species:	Caenorhabditis elegans

Alignment Length:	1402	Identity:	267/1402 - (19%)
Similarity:	489/1402 - (34%)	Gaps:	246/1402 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 SSTQVPEDASSAE--SIQESTTQGSRSSTDISL-------STEASLDDIILSSESIVPTESSTTI 235
            :|.|.|...::.|  :.......|:..|.:.|:       :...|.|.:....|.:...||....
Worm    18 NSIQYPHSPAATECPAYFNGNIAGNACSREYSICVNGVRQAATCSDDSVFYEDECVPVDESPECR 82

  Fly   236 ISSSTEGSWESHISTDSSIGSKVESLLIEALYSLIQESSSSSESPVSNEPSTGATDDS----SST 296
            :..:||.....:...|.:  ||.     :.:||:  ..|:...|.|:.........||    ..|
Worm    83 VDENTEEDDTPYAEFDCT--SKQ-----DGIYSI--GCSNQFISCVAGGAYMAKCPDSLVFNERT 138

  Fly   297 ESLPDSTQE-SSSSSESPVSFELSTEATNESSSS-----ESLPNSSTQDSSSSTETSFQTESTTD 355
            :...:|..| ...::.:|..:|...|...|:|..     |..|::...||........:..:..|
Worm   139 QDCRESCDEVKQDTTTAPQVYEDGEEGYGEASGEIAGDYERQPSNEQPDSIDFDCNGLEDGNYAD 203

  Fly   356 ATDE-----SSSTESQ----PDSTTQESSSSTEGPLSTESSTAVTDQSSSTESSQDSTTQESSSS 411
            ..::     |::...|    |.:....:..|.:...:|:..|.....|:||.::......|.||:
Worm   204 GCNDVFYSCSNNMVFQRYCPPGTVFNINQQSCDFQCTTDDPTTTVSYSTSTITTPQEDDSEYSST 268

  Fly   412 TEGPLSTESSTEATNESSSTESSQDSTTQESSSSTEGPLSTESSTEATNESSSTESSQDSTTQES 476
            |...:.:.::|.:.:...:|.:..|:.|  ::::|:.|...:   |....|....||:.:..|.:
Worm   269 TSADVISTTTTPSIDAIETTTTGFDAVT--TTTTTQTPFVCQ---EGQVNSFGMCSSRFNRCQNN 328

  Fly   477 S-SSTEGPLSTESSTEATNESSSTESSQDSTTQESSS-SSEGPLSTESSTEATNESSSTESSQDS 539
            | .|.:.|::|...:............|..|...:.: :|.||.| ::.....:|:...:...|.
Worm   329 SVRSKQCPVNTLFESSLVMCVFDLPQCQPITVPAAPAYNSYGPPS-DTIVSPFDENVRLKPKFDR 392

  Fly   540 TTQ-----------ESSSSTESPLSTEPSTEANESSSTESSQDSTTQESSSSTEDPLSTESSTEA 593
            ..:           ..:|..|:|... |.....      |.:|........:.:.|.||.....|
Worm   393 RRKYHHGKPSYGPVNGNSYLENPFFI-PRHRGG------SHRDHRRYGYGPAIDSPFSTAFRGRA 450

  Fly   594 --TNESSSTESSQDSTTQESSSSTEG--PLSTESSTEGSNESSSTESSQDSTTQKSSSSTESPLS 654
              :::......::....|..:...:|  ....:...||.| :...||:.:....|:..| :..|.
Worm   451 ALSDQFKDYRRARMGKIQGDARKVDGNKRFLIDDEFEGPN-AKFVESNIEQVFPKNRHS-KKQLG 513

  Fly   655 TEPSTEANESSSTESSQD--STTQESSSSTEGPLSTEPSTEANESSSTESSQDSTTQESSSSSEG 717
            .....:..:...|..::|  ..|:...|:..|   ||.|....:|:...:.|....::....:..
Worm   514 PHEDPDGYDDEKTFDAKDLFGATRRKRSAYYG---TEQSVYGQQSAQISARQAQVNKDCQQYTTP 575

  Fly   718 PLSTE----------SSTEANESSSTESSQ--DSTTQESSSSTESPLSTEPSTEANESSSTESSQ 770
            ...|.          |....|..::....:  |.|.:..|.:.....:....|...::|...|:.
Worm   576 TFLTFGDCFDQFIFCSGNGINRMAACPIGETFDKTLRSCSETCGVSTTIVAVTIGTQTSDDLSAP 640

  Fly   771 DSTTQESSSSTEGPLSTEPSTEANESSSTESSQDSTTQESS----SSSEGPLSTESSTEANESSS 831
            ....:....:|:...:.:|||    :.:..|.:..|||.||    |:|..|:....|.:|:...|
Worm   641 SEYIENDGVTTQSTWNDQPST----TQAPNSYESYTTQYSSNDVPSTSAAPIGDRCSLDASGLFS 701

  Fly   832 TESSQDSTTQESSSST-----EDPLSTESSTEATYESSSTESSQDSTTQESSSSTEGPLSTESST 891
            ...||......:.::.     |.....|::.|.||.....|..       |..||..|:.|   |
Worm   702 LGCSQKYIQCSNGAAIVRRCGESLYFNEATQECTYRDEVPECG-------SQGSTSSPVIT---T 756

  Fly   892 EGSNESSSTESSQDSTTQESSSSTESPLSTEPSTEANESSSTESSQDSTTQESSSSTEGPLSTES 956
            .|.::||   :.....:.:..|:|::|:....:..|:.......||...  :.|.|.......|.
Worm   757 PGQDQSS---NYYGIPSDDVPSTTQTPVGDRCAYVASGLFDLGCSQKYI--QCSDSAASVRECEG 816

  Fly   957 STEANESSSTESSQDSTTQESSSSTEGPLSTESSTEGSNESSSTESSQDSTTQESSSSTESPLST 1021
            |...:|.|.:...:|...:..::..              .||||....|.||..:|.|.:.|.:.
Worm   817 SLYFDERSQSCRFRDEVFKCQTADV--------------SSSSTVPYLDFTTTPASPSEDEPTTY 867

  Fly  1022 EPSTEANESSSTESSQDSTTQESSSSTEGPLSTESST---------EASNESSSTESSQDSTTQE 1077
            |||......|.|.:..|:.|    |.::|...|..|:         ..|:.:.......|.:.|.
Worm   868 EPSVAPYIPSVTVNPVDTCT----SLSDGTHGTGCSSFYFVCSHGRLISSGNCQLGEGYDPSVQG 928

  Fly  1078 SSSSTEGPLSTESSTEVTQEPSPTESLPNSSTQGTPCTT--------DNPSSLEPSPSTPGNDDD 1134
            ..:.:|.|.......|||.:....:.:|..:.:....||        |.|:....:.||..:..|
Worm   929 CRTFSEIPARACDEQEVTTDAGLVQLMPYKTLEEVLTTTEAATTVANDGPTDTYITGSTKYSTTD 993

  Fly  1135 SGNSGSENGNSSTS-GSPCTTDNPSDPES------------SSSTP--------------GNDD- 1171
            ||......|:.:|| .|....||.|:.|.            .|.||              ||.:
Worm   994 SGEYTIPYGDETTSTRSYDRADNDSEDEEEDDVEHDQKCTVGSRTPVGFCVRTYLECTDAGNVEK 1058

  Fly  1172 --------DSGNS--------GSENGNSSTSGSPCTTDNPSDPESSSSTPGNDDDSGNSGSESGI 1220
                    ||.::        |.|....:......||..|:.|:.......:.|  |.:....|:
Worm  1059 LCRIGKLFDSHSNRCVPRIGCGKEAIRDAIKDMIATTPAPAQPKQFEGRCAHVD--GEAVFSIGV 1121

  Fly  1221 TSTTGAPYTTDNPASQEPSPSAPENPGDSGNSSSESPPEGATPCTPNAPKKSTTSSYTAHPTPKY 1285
            .|:.....:......|:.|    |:...|.:.......|..:.||  .||..:...|       |
Worm  1122 CSSKYLRCSYGASKLQQCS----EDRVFSNDKLECIVRESVSACT--VPKNPSIKKY-------Y 1173

  Fly  1286 TTEGNKAETSTLKSPTGTTPGHQEDRTDCSNMPNGIFLRDFQSCNKYYVCLNGKAIAGH--CPRN 1348
            |:....|                    .|....:|:: |:.:.|:....|..|: :..|  |..:
Worm  1174 TSNDQSA--------------------FCDGKEDGLY-RNERDCSAILQCFGGE-LFEHPSCQSS 1216

  Fly  1349 LHFDIKRKVCNFPSLVDCPLDEAPENVTKKPSDTESTPDCKSLRNGAYVRDPKSCSRFYVCANGR 1413
            |.|:.....|::           |:.|:...:..::..:|.  .:|:::.|..:|..||.|..||
Worm  1217 LAFNQLTGKCDY-----------PQKVSGCENHGQTNGECS--EHGSFIADANNCEVFYRCVWGR 1268

  Fly  1414 AIPRQCPQGLHFDIKSNFCNYPILV-QCSLEESQADA 1449
            .:...||.|..|:...:.|::|..| .||.:.|.:::
Worm  1269 KVVMTCPSGTVFNPLLSVCDWPSAVPSCSGQASDSNS 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68D	NP_648504.2	ChtBD2	21..69	CDD:214696
		PHA03249	1088..>1209	CDD:223023	34/172 (20%)
		CBM_14	1314..1366	CDD:279884	11/53 (21%)
		CBM_14	1388..1440	CDD:279884	16/52 (31%)
		ChtBD2	1459..1505	CDD:214696
cbd-1	NP_502145.2	ChtBD2	97..141	CDD:214696	11/52 (21%)
		ChtBD2	191..237	CDD:214696	5/45 (11%)
		CBM_14	692..743	CDD:307643	10/50 (20%)
		CBM_14	785..836	CDD:307643	10/52 (19%)
		CBM_14	1108..1161	CDD:307643	9/58 (16%)
		CBM_14	1182..1235	CDD:307643	13/65 (20%)
		CBM_14	1251..1296	CDD:307643	14/44 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D487374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109854
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820