DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc68D and cpg-2

DIOPT Version :9

Sequence 1:	NP_648504.2	Gene:	Muc68D / 39326	FlyBaseID:	FBgn0036203	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_498551.3	Gene:	cpg-2 / 175991	WormBaseID:	WBGene00015102	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	123/523 - (23%)
Similarity:	175/523 - (33%)	Gaps:	145/523 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1043 ESSSSTEGPLSTESSTEASNESSSTESSQDSTTQESSSSTEGPLSTESSTEVTQEPSPTESLPNS 1107
            |||..|.|..|.|||.|||.|.|...|.:.|.......|.|.......|.|.|.| :..|:|.:.
Worm    81 ESSGETSGEGSGESSGEASGEGSGEASGEGSGEASGEGSGEASGEGSGSGEETVE-NVCENLEDG 144

  Fly  1108 STQGTPCT------TDNPSSLEPSPSTPGNDDDSGNSGSENGNSSTSGSPCTTDNPSD--PESSS 1164
            :.....||      |.|.:.....|:....|.||              ..|...:..:  .|..:
Worm   145 AYSSGGCTTYYFFCTTNTARFLSCPTPLFYDADS--------------QKCIWKSLVEECKEDLT 195

  Fly  1165 STPGNDDDSG-NSGSENGNSSTSGSPCTTDNPSDPESSSSTPGNDDDSGNSGSESGITSTTGAPY 1228
            .|.|:.:.|| .||..:|.:|..|                       ||.:..||
Worm   196 ITDGSGETSGEGSGEASGEASGEG-----------------------SGEASGES---------- 227

  Fly  1229 TTDNPASQEPSPSAPENPGDSGNSSSESPPEGATPCTPNAPKKSTTSSYTAHP-----TPKYTTE 1288
                                ||..|.|:..||:....|....|:.    ..||     |...|..
Worm   228 --------------------SGQGSGEASGEGSGELEPTCEGKAD----GIHPNGVCSTNFLTCS 268

  Fly  1289 GNKAE-----TSTLKSPTGTTPGHQEDRTDCSNMP--------NGIFLRDFQSC-NKYYVCLNGK 1339
            |..|.     .|.:.:||........|..:|:.:|        :|.|  .|..| :.:..|.||:
Worm   269 GGIARIMDCPASLVFNPTILVCDWPRDVAECAGLPTPQPTCEEDGYF--SFGQCSSSFTACTNGR 331

  Fly  1340 AIAGHCPRNLHFDIKRKVCNFPSLV-DC----------------------PLDEAPENVTKKPSD 1381
            ||...||..|.|......|::.|.| :|                      ...||....:.:.|.
Worm   332 AIVMFCPAGLKFSESTVRCDYESNVSECQETSGEESGEASGEQSGEGSGEASGEASGESSGEGSG 396

  Fly  1382 TESTPDCKSLRNGAYVRDPKSCS-RFYVCANGRAIPRQCPQGLHFDIKSNFCNYP-ILVQCSLEE 1444
            .|....|..|.||.:.   ..|| |...|.||.....:||..|.|:.:|..|:|| ..::|.:|:
Worm   397 VEEQNQCVGLDNGLHA---IGCSPRVLSCQNGHVDIFECPSSLVFNDQSLICDYPQTSLKCLIED 458

  Fly  1445 SQADAHGALLAEGVP----DCTKVKEDTRFGDVKQHNKYYVCLKGKAVLHYCSPGN-WFDLRSQK 1504
            :       :|.:..|    ||:   .|..|.|......|:.|..|:.:...|:..| .|...:.:
Worm   459 T-------ILIDETPIAAFDCS---TDGLFSDGLCSATYHQCTAGQLINFTCAASNAVFSAANTE 513

  Fly  1505 CID 1507
            |:|
Worm   514 CVD 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68D	NP_648504.2	ChtBD2	21..69	CDD:214696
		PHA03249	1088..>1209	CDD:223023	25/129 (19%)
		CBM_14	1314..1366	CDD:279884	18/61 (30%)
		CBM_14	1388..1440	CDD:279884	18/53 (34%)
		ChtBD2	1459..1505	CDD:214696	12/50 (24%)
cpg-2	NP_498551.3	CBM_14	24..76	CDD:279884
		CBM_14	138..190	CDD:279884	11/65 (17%)
		ChtBD2	245..293	CDD:214696	11/51 (22%)
		CBM_14	311..359	CDD:279884	16/49 (33%)
		CBM_14	403..454	CDD:279884	18/53 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D487374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109854
Panther	1	1.100	-	-	O	PTHR23301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920