DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc68D and si:ch211-286b4.4

DIOPT Version :9

Sequence 1:	NP_648504.2	Gene:	Muc68D / 39326	FlyBaseID:	FBgn0036203	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_021322239.1	Gene:	si:ch211-286b4.4 / 100005359	ZFINID:	ZDB-GENE-131127-605	Length:	2996	Species:	Danio rerio

Alignment Length:	1702	Identity:	338/1702 - (19%)
Similarity:	491/1702 - (28%)	Gaps:	437/1702 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FC-AGQS---------FGS-------RAVDSEDPQSYYLCLGFIGPIKNTCKNGYLFDAQSQGCV 69
            || ||.|         |||       ....|..|..|....|...| ...|..||.       ||
Zfish   159 FCPAGASHMEPCPLGTFGSLEGAASVEMCQSCTPGHYCAESGLTSP-SGPCSPGYY-------CV 215

  Fly    70 IMNNATQSIKKSNDHKKEVTIKQNISVDRPL---IFNIFGNFNFFASLWGNSHETTPSPLKPNPI 131
                       ...|........|...:.|:   ..:|:.:..|...:....|......::|.|.
Zfish   216 -----------QGSHTPAPQYYNNTVCEEPVGHSAEDIYSHLQFIGDICPAGHYCPIGSVRPEPC 269

  Fly   132 --AHFQFINSAVGIEPLSQDNLADKDKKDIISSSSDSSPTEDATYSST--QVSSTQVPEDASSAE 192
              ..||....||                    |.:|..|.....|...  |.|:..:..:.|...
Zfish   270 PPGFFQGQRGAV--------------------SETDCQPCTSGYYCPDWGQSSAELLCPEGSFCP 314

  Fly   193 SIQESTTQGSRSSTDISLSTEASLDDIIL---------SSESIVPTESSTTIISSSTEGSWESHI 248
            ....:..|..|...........|::..|.         |..|..|..|....:...|     |.:
Zfish   315 PGSPTGHQPERQCPSGHACPYGSVEPAICLPGTYQPLPSQPSCQPCPSGFYCLEGCT-----SPL 374

  Fly   249 STDSSIGSKVESLLIE--------ALYSLIQESSSSSESPVSNEPSTGATDDSSSTESLPDS--- 302
            ...:...|.:|.|..:        ..|.    ::|:..|| |...|.|....|.:||..|.|
Zfish   375 PCPAGTASVIEGLQSQRDCSPCPPGFYC----NTSALISP-SGPCSAGHFCSSGATEPAPVSQMY 434

  Fly   303 ----------TQESSSSSESPVSFELSTEATNESSSSESLPNS-------STQDSSSSTETSFQT 350
                      .::||:....||.|.|..:.....:...|.|.|       |||.|.|.....:..
Zfish   435 GDICPAGHYCPEQSSAPLPCPVGFILRDKGATSFNDCSSCPPSRYCAAPGSTQPSGSCAPGHYCV 499

  Fly   351 ESTTDATDESSSTESQ--------PDSTTQE------SSSST-------EGPLSTESSTAVTDQS 394
            :...  |....:|.||        |.|..|:      ..:.|       :|.:.|:     .|..
Zfish   500 KGAD--TSRPQATLSQQTCFCDLIPSSHLQKYDLCHLKHNITCAIHIPGDGAVWTD-----LDPR 557

  Fly   395 SSTESSQDSTTQESSSSTEGPLSTESSTEATNESSSTESSQDSTTQESSSSTEGPLSTESSTEAT 459
            ...||......:|..:..:|.|.      .|.......||........|...:..|.|.......
Zfish   558 PLLESEAPLQIREPCTGFKGDLC------PTGSYCPVGSSVPQPCDSGSYCNQTGLYTPVGLCFA 616

  Fly   460 NESSSTESSQDSTT-----QESSSSTEGPLSTESSTEATNESSSTES-----------SQDSTTQ 508
            .....|.||..|..     ......|..|||....|..::...|:..           .|...|:
Zfish   617 GFFCPTGSSNPSAVLCPPGHYCPQGTPRPLSCPQGTVRSSAGGSSAGDCLECPPGYFCEQRGLTE 681

  Fly   509 ESSSSSEG---PLSTESSTEATNESSSTESSQDSTTQESSSSTESPLSTEPSTEAN--------- 561
            .|...|||   |....:|..|.....:....|.....|...   .|.:.:||...:
Zfish   682 PSGLCSEGYYCPGGQNTSRPAEYVCRAGHFCQRGIIMERPC---FPGTFQPSPGQHRCDVCPARF 743

  Fly   562 ---ESSSTE--SSQDSTTQESSSSTEDPLSTESSTEATNESSSTESSQ-DSTTQ---ESSSSTEG 617
               |...|.  ..|........:|.:.|.........:..:.|:|.|| |..|.   ..:.|..|
Zfish   744 FCPEHGMTHPFPCQPGYYCPVGASNQHPCPPGGFGNRSGLADSSECSQCDPGTYCMGSGNVSPTG 808

  Fly   618 PLSTESSTEGSNESSSTESSQDSTTQKSSSSTESPLSTEPSTEANESSSTESSQDSTTQESSSST 682
            |.|......|....||...::  |.....|....|..:.......:.:.:.|||.|...:..:.|
Zfish   809 PCSAGFLCFGGAVLSSPNDNE--TGMLCPSGFYCPAGSFAGIPCPKGTFSNSSQLSKISQCQNCT 871

  Fly   683 EGPLSTEPSTEANESSSTESSQDSTTQESSSSSEGPLSTESSTEANESSSTESS----------Q 737
            .|...:||               ..|..|.....|...:|.|..|...|:...|          .
Zfish   872 PGFYCSEP---------------GLTAVSGPCLPGYYCSEGSPSAAPVSAVYGSVCPPGHYCVVG 921

  Fly   738 DSTTQESSSSTESPLSTEPSTE----------ANESSSTESSQDSTTQESSSSTEGPLSTEPSTE 792
            .:........|..|.|...:|:          .::...:|.....|.....:.|.|.........
Zfish   922 SAVPAPCPVGTRRPDSRGKATDDCMPCPGGQFQDQRGQSECKPCPTGFHCINLTSGSTGVSSPII 986

  Fly   793 ANES----SSTESSQDSTTQESS-SSSEGPLSTE------------SSTEANESSS--------T 832
            ..|.    :.|:|.......:.: |.|.|.:|.|            |...:|.|.:        .
Zfish   987 CPEGFYCPNETQSGNPVPCPKGTYSDSLGLISAEQCLVCPMGYFCGSVGLSNPSGACAPGFLCFV 1051

  Fly   833 ESSQDSTTQESSSSTEDP-----LSTESS--TEATY---ESSSTESSQDSTTQESSSSTEGPLS- 886
            :::..:.|..|:.|...|     |.|.:.  :|..|   .|||.|.|.........:.|..||:
Zfish  1052 QATVPNPTDNSTGSLCPPGAFCLLGTRAGECSEGYYCDWGSSSPEQSLCPAGFYCPAGTNKPLAC 1116

  Fly   887 ---TESSTEGSNESSSTESSQDSTTQESSSSTE---------SPLSTEPSTEANESSSTESSQDS 939
               |.||..|::...:.|........:..:..|         .||||...|:......|...|..
Zfish  1117 TGGTFSSVMGNSHRENCEPCPLGFYCQGDAVAEPLPCPPGHFCPLSTSQGTQFPCPPGTMQPQSG 1181

  Fly   940 TTQESSSSTEGPLSTESS---TEANESSSTESSQDS-TTQESSSSTEGPLSTESSTEGSN----- 995
            |     :|.|..|...|.   .....|..|...||. .....::|.:|..:|..|| |:|
Zfish  1182 T-----ASVEECLPCPSGMFCASHGLSEPTGRCQDGFHCPSGATSPDGTGNTIEST-GNNICPPG 1240

  Fly   996 ----ESSSTESSQDSTTQESSSSTESPLSTEPSTE---ANESSSTESSQDSTTQESSSSTEGPLS 1053
                ....:.....:.|..||.....|...:|...   ..:::....||.:..........|
Zfish  1241 HYCPTGIGSPLPCPAGTFSSSPGLSGPEQCQPCPPGYFCEQTAMVHPSQAALCDAGYVCING--- 1302

  Fly  1054 TESSTEASNESSSTESSQDSTTQESSSSTEG-PLSTESSTEVTQEPSPTESLPNSS-----TQGT 1112
                   |..:...:..|........|...| ||      ||..||....|:|.::     ..||
Zfish  1303 -------SRSARPVDGLQGYICPSGHSCPIGAPL------EVPCEPGTYSSVPGAARCLLCPAGT 1354

  Fly  1113 PCTTDNPSSLEPSPSTPGNDDDSGNSGS-----------ENGNSSTSGSPCTTD------NPSDP 1160
            .|  .:|.:|||||...|:....|.:.:           ....|..:..||.|.      ..|.|
Zfish  1355 MC--PSPGTLEPSPCPMGHFCPVGTAEAVPCPVGTLGQGTRAQSEAACVPCPTGLYCSSAGTSQP 1417

  Fly  1161 ----------ESSSSTPGNDDDSG---NSGSENGNSSTSGS----PCTTDN-------------- 1194
                      :..|..|...:.:|   |.....|:...||:    ||...:
Zfish  1418 QGQCQQGYFCQGGSPNPAPLNTTGYLRNGPCPQGHFCPSGTLMPLPCPAGSIRNLTGGYSLESCL 1482

  Fly  1195 PSDPESSSSTPGNDDDSGNSGS----ESGITSTT--------------GAPYTTDNPASQ-EPSP 1240
            |.......::.|.|..:|...:    ....:|||              |:|.....|..| :|:|
Zfish  1483 PCPAGHYCASEGLDAPTGPCAAGFYCPVDFSSTTAHAFLCPKGHFCPLGSPLALPCPTGQYQPNP 1547

  Fly  1241 SA----PENPGDSGNSSSESPPEGATPCTPNAPKKSTTSSYTAHPTPKYTTEGNKAETSTLKSPT 1301
            .:    |..||.....:....|.   ||.|:    |...:.|..|.|               .|.
Zfish  1548 GSDNCIPCRPGFYCEEAIIGDPR---PCPPH----SYCPAATMVPQP---------------CPN 1590

  Fly  1302 GT-TP----GHQEDRTDCSNMPNGIFLRDFQ---SCNKYYVCLNGKAIAGHCPRNLHFDIKRKVC 1358
            || ||    |.||:| :|...|:|.|.:..|   .|...::|::|.  :...|:: .|.|.|..|
Zfish  1591 GTYTPSEVGGLQEER-ECLPCPSGKFCKAGQVKGLCAAGFLCISGS--SDFTPQS-SFLINRDQC 1651

  Fly  1359 NF--------PSLVDCPLDEAPENVTKKPSDT-ESTPDCKSLRNGAYVRDPKSCSRFYVCANGRA 1414
            .:        |:...||  |..|.....||:| ...|...||      ||...|.....|..|..
Zfish  1652 EWGAQCAGPCPAGYYCP--EGTEEPLSCPSNTLRENPGASSL------RDCLPCPPKQWCREGDP 1708

  Fly  1415 IPRQCPQGLHFD 1426
            |||.||.|.:.|
Zfish  1709 IPRMCPPGYYCD 1720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68D	NP_648504.2	ChtBD2	21..69	CDD:214696	16/63 (25%)
		PHA03249	1088..>1209	CDD:223023	34/173 (20%)
		CBM_14	1314..1366	CDD:279884	14/62 (23%)
		CBM_14	1388..1440	CDD:279884	14/39 (36%)
		ChtBD2	1459..1505	CDD:214696
si:ch211-286b4.4	XP_021322239.1	Ephrin_rec_like	<945..983	CDD:311571	4/37 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D487374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010