DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32087 and VMP1

DIOPT Version :9

Sequence 1:	NP_729740.2	Gene:	CG32087 / 39323	FlyBaseID:	FBgn0052087	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001316324.1	Gene:	VMP1 / 81671	HGNCID:	29559	Length:	419	Species:	Homo sapiens

Alignment Length:	418	Identity:	181/418 - (43%)
Similarity:	259/418 - (61%)	Gaps:	55/418 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAASNDTEAGHSSLPSEIDRLAELVQERLEWKSLVLWRRPVQTLKYGGLEAGHLLLSFIEKLLNL 65
            :|.:.:...|:.:.||.::....  :||.|.:::||||:|:.||:|..||   :|:...|....|
Human    13 VAMNKEHHNGNFTDPSSVNEKKR--REREERQNIVLWRQPLITLQYFSLE---ILVILKEWTSKL 72

  Fly    66 W-----LVGGLLLLGMFC---LLPGPHADFVIFCKHRFGFAVYWLGLGVLSSVGFGTGLHTFLLY 122
            |     :|..||||.:..   .:.|.|..:|...:.:|....||:|||:|||||.||||||||||
Human    73 WHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLY 137

  Fly   123 LGPHLAAVTLAAYECQTLDFPTPPYPDIKVCPQEPYKRNYPDVWQILAKVRPEALLWGIGTALGE 187
            ||||:|:||||||||.:::||.|||||..:||.|........:|.|::|||.||.:||||||:||
Human   138 LGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGE 202

  Fly   188 LPPYFMTRRARLSGKELDGAEEEKLLDERRRCGKLGMLDH----------AKLFMERVMRRVGFM 242
            ||||||.|.|||||.|.|..|.::..:         ||:|          |||.:::::::|||.
Human   203 LPPYFMARAARLSGAEPDDEEYQEFEE---------MLEHAESAQDFASRAKLAVQKLVQKVGFF 258

  Fly   243 GILFCASVPNPLFDLAGITCGHFLVPFWKFFVATLIGKALIKATIQQLFVIASLTESLVDRFVVG 307
            |||.|||:||||||||||||||||||||.||.|||||||:||..||::|||.:.::.:|::.|..
Human   259 GILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAF 323

  Fly   308 LG-------------KLPYLGPPMQRMIRELLQSTKQQMH-----GTVNSNSLAYLSHLVRAFEL 354
            :|             .:|.:||.:|:..:|.|::.:|::|     ||....:  :||.:   ||.
Human   324 IGLEDNGALQPPPPSAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGEN--WLSWM---FEK 383

  Fly   355 CAFIMVTCFVVSSLNCLAQIHCKRQQEK 382
            ...:||..|::|.:|.:||.:.||.|::
Human   384 LVVVMVCYFILSIINSMAQSYAKRIQQR 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32087	NP_729740.2	SNARE_assoc	<233..282	CDD:294297	37/48 (77%)
VMP1	NP_001316324.1	SNARE_assoc	<247..298	CDD:294297	37/50 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1109
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54823
OrthoDB	1	1.010	-	-		D468248at33208
OrthoFinder	1	1.000	-	-		FOG0003786
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103371
Panther	1	1.100	-	-	O	PTHR10281
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.720