DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnai2 and dync2i2

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001099160.1	Gene:	dync2i2 / 794361	ZFINID:	ZDB-GENE-070928-9	Length:	501	Species:	Danio rerio

Alignment Length:	424	Identity:	97/424 - (22%)
Similarity:	175/424 - (41%)	Gaps:	62/424 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 QNNAVNIYENYFENLDPAPLPEPCKSRTVNVYRDPNPIKVPVKHLSWSPDGG-IKMAVSHCDMRF 183
            :|:..:.::.:..|.:.......|..|..:|  |.....:.|..:||:..|. |.......|
Zfish    90 KNSKSHAFDGFEVNWEEQNESVSCMYRLQHV--DAQEKSLQVTSVSWNCTGSVIACGFGRVD--- 149

  Fly   184 QGDKSNQKCNSYIWEVE----NPNEPFLTLEPKVPCVCLEYNQKDPTSLVSGMYNGQVAAWDTRH 244
            .||.||:|.....|.|:    ||..|.:.::...|.:||.::...|:.:..|:|:|:|..|||..
Zfish   150 DGDWSNEKACVCTWNVDRQNLNPKRPDVIIDVATPVMCLCFHPVRPSVVAGGLYSGEVVVWDTSR 214

  Fly   245 GKLPVMISEREV---CHRDPVNSVLWNNSKSGTEF--FSGGSDGQVLWW----DTRKLTEPLDRL 300
            .: .:::::..:   .||:||..:.|.......||  .|.||.|:||.|    ...||      |
Zfish   215 SQ-DLILAQTGMSADTHREPVYQINWVPGARRGEFSVLSAGSGGRVLLWTIDGSEAKL------L 272

  Fly   301 LMDPVKSDDQDLSRSYGISVLEYETTIPT-----------RFMAGTEMGMLFSCNRKGKTPT--- 351
            |........|.:.:|...|......||..           .|:.|:|.|::..|:...:|..
Zfish   273 LSSGYALVRQQMPQSGAASKTRGSLTIGVTAVALSPWDLDTFLVGSEGGLVLKCSFSSETAAAVP 337

  Fly   352 ---EKIQIRMMCHL------GPVYAITRNPAFVKNFLTVG-DWCARIWS--EDCRESSIIWTKSS 404
               |.:.:|.....      ||::::..:|.....|::|| |..|.:.|  :.|   .::..:.|
Zfish   338 SDGESVILRAPMQFSFSPRGGPIHSVHFSPFHRNLFVSVGTDGLAHLHSVLQPC---PLLALRVS 399

  Fly   405 SSMLTDGAWSYTKVSQFFITRMDGVLDTWDLLQQQNEPVLTV--KVCDEPLYCVRTN-ENGKFVS 466
            .|.:....||.|:...|......|::..:||.::...||.|:  ....:|.||:..| ::...::
Zfish   400 DSYVFGVRWSPTRPLVFAAVTGQGLVQMFDLGRRSLRPVATIDQNAGGQPAYCLEFNPKHTNLLA 464

  Fly   467 CGSQLGATFLVEVSDNMVMSAKNDKPLLTAMFER 500
            .|:..|:..:.::|..:......:    |||.|:
Zfish   465 VGNADGSVNIWQLSAELTEQGAKE----TAMLEQ 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	87/364 (24%)
		WD40 repeat	162..208	CDD:293791	15/50 (30%)
		WD40	212..469	CDD:295369	68/294 (23%)
		WD40 repeat	215..254	CDD:293791	10/38 (26%)
		WD40 repeat	262..304	CDD:293791	15/47 (32%)
		WD40 repeat	318..355	CDD:293791	10/53 (19%)
		WD40 repeat	365..401	CDD:293791	8/38 (21%)
		WD40 repeat	408..433	CDD:293791	5/24 (21%)
dync2i2	NP_001099160.1	WD40	66..481	CDD:225201	93/405 (23%)
		WD40 repeat	130..180	CDD:293791	15/52 (29%)
		WD40 repeat	187..229	CDD:293791	10/42 (24%)
		WD40 repeat	235..296	CDD:293791	17/66 (26%)
		WD40 repeat	301..338	CDD:293791	6/36 (17%)
		WD40 repeat	361..399	CDD:293791	8/40 (20%)
		WD40 repeat	403..442	CDD:293791	10/38 (26%)
		WD40 repeat	450..477	CDD:293791	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810