DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnai2 and dync1i1

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_009290517.1	Gene:	dync1i1 / 561525	ZFINID:	ZDB-GENE-061215-62	Length:	647	Species:	Danio rerio

Alignment Length:	400	Identity:	84/400 - (21%)
Similarity:	160/400 - (40%)	Gaps:	81/400 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VKHLSWSPDGGIKMAVSHCDMRFQGDKSNQKCNSYIWEVENPNEP----------FLTLEPKVPC 215
            |..|.|||.....:..|:        .:|:         :.|:||          |....|:...
Zfish   291 VTSLDWSPQYPELLVASY--------NTNE---------DAPHEPDGVVLVWNMKFKKATPEYIF 338

  Fly   216 VC------LEYNQKDPTSLVSGMYNGQVAAWDTR-HGKLPVMISE-REVCHRDPVNSVLWNNSKS 272
            .|      :.:.|..|..::.|.|:||:|.||.| |.:.||..:. ....|..||..|....:::
Zfish   339 HCQSSVMSVGFAQFHPNLVIGGTYSGQIAMWDNRSHRRTPVQRTPLSATAHTHPVYCVNVVGTQN 403

  Fly   273 GTEFFSGGSDGQVLWWDTRKLTEPLDRLLMDPVKSDDQDLSRSYGISVLEYETTIPTRFMAGTEM 337
            .....:..:||::..|....|::|.:.:.:...|      |:...::.:.:..:....::.|:|.
Zfish   404 ANNLITVSTDGKMCSWSLDMLSQPQESMELIYNK------SKPVAVTCMAFPASDVNNYVVGSEE 462

  Fly   338 GMLFSCNRKGKTPTEKIQIRMMC--HLGPVYAITRNPA-----FVKNFLTVG-DWCARIWSEDCR 394
            |.:::.:|.|    .|..|..:.  |.|||..|:.:.|     |...|.|.. ||..::||  .:
Zfish   463 GTVYTASRHG----SKAGIGEIFDGHQGPVTGISCHNAVGPVDFSHLFTTSSFDWTVKLWS--TK 521

  Fly   395 ESSIIWT-KSSSSMLTDGAWSYTKVSQFFITRMDGVLDTWDLLQQQNEPVLTVKV---CDEPLYC 455
            .:..::: :.::..:.|..||....:.|.....:|.||.|:|......|..:|.|   |  .|..
Zfish   522 HNKPLYSFEDNADYVYDVMWSPVHPALFATVDGNGRLDLWNLNNYTEVPSASVSVEGGC--ALNR 584

  Fly   456 VRTNENGKFVSCGSQLGATFLVEVSDNMVMSAKNDKPLLTAMFERENRREKILEAKSRESKLKVK 520
            ||....|:.|:.|...|..::.:|.:.:.:...:|                  .:|...:.::::
Zfish   585 VRWASGGREVAVGDSEGRVWIYDVGEQLAVPHTDD------------------WSKFGRTLMEIQ 631

  Fly   521 ANH--GQDQG 528
            ||.  |:::|
Zfish   632 ANRGDGEEEG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	78/350 (22%)
		WD40 repeat	162..208	CDD:293791	10/55 (18%)
		WD40	212..469	CDD:295369	63/276 (23%)
		WD40 repeat	215..254	CDD:293791	14/46 (30%)
		WD40 repeat	262..304	CDD:293791	7/41 (17%)
		WD40 repeat	318..355	CDD:293791	6/36 (17%)
		WD40 repeat	365..401	CDD:293791	10/41 (24%)
		WD40 repeat	408..433	CDD:293791	7/24 (29%)
dync1i1	XP_009290517.1	Dynein_IC2	147..175	CDD:288403
		WD40	215..608	CDD:225201	77/347 (22%)
		WD40	284..607	CDD:295369	77/346 (22%)
		WD40 repeat	292..337	CDD:293791	11/61 (18%)
		WD40 repeat	347..388	CDD:293791	13/40 (33%)
		WD40 repeat	394..437	CDD:293791	6/42 (14%)
		WD40 repeat	443..490	CDD:293791	11/50 (22%)
		WD40 repeat	498..530	CDD:293791	7/33 (21%)
		WD40 repeat	536..574	CDD:293791	10/37 (27%)
		WD40 repeat	582..608	CDD:293791	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810