DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnai2 and CG14838

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	131/710 - (18%)
Similarity:	228/710 - (32%)	Gaps:	269/710 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DINMHDPEQTVRYKRKIEKDENYITQVM---NLTKPMEHYIHQNNAVNIYENY----------FE 132
            |.::....|.|:|...      |:.:.:   |::|..:.::..      |:.|          :.
  Fly   361 DYSLISSRQVVQYTNP------YLQEFLCFANISKSNKRFVAG------YDWYPKLSGLIAVSYA 413

  Fly   133 NLDPAPLPEPCKSRTVNVYR---DPNPIKVPVKHLSWSPDGGIKMAVSHCDMRFQGDKSNQKCNS 194
            ...||.:.| ..:|...|.|   :|||:      |.||                ..|..|.|
  Fly   414 FSTPATVNE-ATNRVDYVQRAVLEPNPV------LLWS----------------FSDNLNYK--- 452

  Fly   195 YIWEVENPNEPFLTLEPKVPCVCLEYNQKDPTSLVSGMYNGQVAAWDTRHGK------------- 246
                        |..|..:....|.:...:...|:.|..||||..||.: |:
  Fly   453 ------------LEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQ-GRCEKLDEEEYLTAA 504

  Fly   247 -----------------------LPVMISEREVCHRDPVNSVLW--------------------N 268
                                   :|..||..:...:..:.:..|                    |
  Fly   505 QAKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRN 569

  Fly   269 NSKSGTEFFSGGSDGQVLWWD------------------TRKLT--------------------E 295
            :.|.   |.:...||.:.:||                  .::||                    |
  Fly   570 HHKF---FVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPE 631

  Fly   296 PLDRLLMD--------PVKSDDQDLSRSYGISVLEYE-TTIPTRFMAGTEMGMLFSCNRKGK--- 348
            |:..::.|        ||....|....:|.|..:..: .|:....:..|..|.:...:.:|.
  Fly   632 PITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTE 696

  Fly   349 -TPTEKIQIRM---MCHLGPVYAITRNPAFVKNFLTVGDWCARIWSEDCRESSIIWTKSSSSMLT 409
             ..||.|...:   |.|.|||..:.:||.:.:.|.::|.....||.||...|.|.|.|.:.. ||
  Fly   697 GEATEVINSSIPFAMVHDGPVVMVKKNPFYPELFASIGRTILAIWKEDYNYSPIFWRKRACD-LT 760

  Fly   410 DGAWSYTKVSQFFITRMDGVLDTWDLLQQQNEPVLTVKVCDEPLYCV---RTNENGKFVSCGSQL 471
            ..|||.|:.:..::||:||:|:.||:|.:.::..||..:....:..:   |.:...|.:..|...
  Fly   761 AVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILGIGDYN 825

  Fly   472 GATFLVEVSDNMVMSAKNDKPLLTAMFERENRRE-----------------------------KI 507
            .:..:|::..:..:...|:...|.....:|.||:                             |.
  Fly   826 SSIRMVKLPHSFDVPLPNELDQLIKYVLKEERRKMGIQSWEQKYYELNKDIIEAKREAAAEIRKE 890

  Fly   508 LEAKSRESKL---KVKANHGQDQGD---------------------------------TMMVNGK 536
            :|.|.:|.:|   |.....|:|.|:                                 |::::.|
  Fly   891 MEKKEKEEQLASRKKGQKSGEDGGEGGEEIKGKKNYSGLNYNEKMAVKWDELNLNRMMTILMSRK 955

  Fly   537 INMAP---------------FEAACEQAASEYFAAVEQE----RQRRLPGGKQDAEEADV 577
             .|.|               :|||.:::..:..|.||.:    |.|.||...||.:.:::
  Fly   956 -QMDPEKLARETALEKERHAYEAAKKKSHLDILATVENDIANIRSRILPLELQDMQRSEM 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	83/434 (19%)
		WD40 repeat	162..208	CDD:293791	6/45 (13%)
		WD40	212..469	CDD:295369	73/369 (20%)
		WD40 repeat	215..254	CDD:293791	13/74 (18%)
		WD40 repeat	262..304	CDD:293791	13/107 (12%)
		WD40 repeat	318..355	CDD:293791	7/41 (17%)
		WD40 repeat	365..401	CDD:293791	11/35 (31%)
		WD40 repeat	408..433	CDD:293791	11/24 (46%)
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	47/291 (16%)
		WD40 repeat	462..505	CDD:293791	10/43 (23%)
		WD40 repeat	510..547	CDD:293791	3/36 (8%)
		RE_R_Pab1	807..>863	CDD:286594	9/55 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435259
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840