DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnai2 and CG13930

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	134/602 - (22%)
Similarity:	226/602 - (37%)	Gaps:	145/602 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ERRSFGARVHFEDKDEVVFTENSNPELVK-SYILKNPVDRVTQYAGQTSL---SVANTERATYKS 68
            ||||..|....|:..:|:.......||:. :...:..||..||  ..|:|   .:.||||.|
  Fly   118 ERRSMTALADTEEGRQVMEDNRKYDELLSGTDKTRRTVDADTQ--TMTALMKSRLVNTERLT--- 177

  Fly    69 TGITHNEGGWPKDINMHDP----EQT-----VRYKRKIEKDENYITQV-----------MNLTKP 113
               |...|.:..:..|:|.    |::     |:..:|:|....::..|           ..|...
  Fly   178 ---TAQMGSYVSNFEMYDTYTDLEKSTTSVQVQGAKKMEITTYHVGGVDQFVGINCLPGFRLALM 239

  Fly   114 MEHYIHQNNAVNIYENYFENL-DPAPLPEPCKSRTVNVYR------------DPNPIKVPVKHLS 165
            :...|..:|.....:..:.|: .|.||.|..|.:    ||            ||. :...|..:|
  Fly   240 LTMRILASNVFEPQQRRYRNMAPPDPLAEDVKFK----YRLGLLWRLSPPSSDPK-VHQAVSDMS 299

  Fly   166 WSPDGGIKMAVSHCDMRFQGDKSNQKCNS-------YIWEVENPNEPFLTLEPKVPCVCLEYNQK 223
            :.|..|..|||::      |..|:.|.:.       |:|.::||..|......:||.|.:|::..
  Fly   300 FCPSNGDIMAVAY------GVYSHGKVSKLPRSGWVYVWNIKNPVNPERRYHYQVPVVTVEFSPT 358

  Fly   224 DPTSLVSGMYNGQVAAWDTRHGKL-PVMISER-EVCHRDPVNSVLWNNSKSG--------TEFFS 278
            .|..|..|::||.|...|.....| |:.:|:| ...:.:||.::.|...:..        |.|.:
  Fly   359 QPQLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSSPYFEPVTAIKWIYFEGDVGCRNPHITPFLA 423

  Fly   279 GGSDGQV-----------LWWDTRKLTE--------PLDR-----------------LLMDPVKS 307
            ....|.|           |..:.::|..        |::|                 :::|||:|
  Fly   424 TSQAGAVTKYRLINSPNMLGLEQQRLQRAEGELEGIPIERQPPAASLLANRHPQCLEIVLDPVQS 488

  Fly   308 DDQDLSRSYGISVLEYETTIPTRFMAGTEMGMLFSCNRKGKTPTEKIQIRMMCHLGPVYAITRNP 372
            |                     .:...|:.|.|:.|:.  ..|.:.:::|.: |.||...:..:|
  Fly   489 D---------------------IYYVLTDEGTLYKCST--NYPLQHLELRQV-HDGPAACMEFSP 529

  Fly   373 AFVKNFLTVG-DWCARIWSEDCRESSIIWTKSSSSMLTDGAWSYTKVSQFFITRMDGVLDTWDLL 436
            ...:.:||.| |||.|||..... ..|:..:...|.:....||.|. |...::.....:|.|||.
  Fly   530 WSPRMYLTCGSDWCIRIWLAGIL-LPIVTLQHHLSPVHCARWSRTH-STILVSLSRSTVDIWDLR 592

  Fly   437 QQQNEPVLTVKVCDEPLYCVRTNENGKFVSCGSQLGATFLVEVSDNMVMSAKNDKPLLTAMFERE 501
            ....:||.:..:..:..|     ...||..||..|.   :...:.|::|.:..|.| ....|:.:
  Fly   593 NSTMKPVSSTVIDADIFY-----TTFKFTHCGRSLA---VGNEAGNLLMLSFEDMP-FPPHFQYK 648

  Fly   502 NRREKILEAKSRESKLK 518
            ..:..|.:|.|.:..|:
  Fly   649 QLKRAIFKALSMQPDLR 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	83/375 (22%)
		WD40 repeat	162..208	CDD:293791	14/52 (27%)
		WD40	212..469	CDD:295369	66/303 (22%)
		WD40 repeat	215..254	CDD:293791	12/39 (31%)
		WD40 repeat	262..304	CDD:293791	10/85 (12%)
		WD40 repeat	318..355	CDD:293791	5/36 (14%)
		WD40 repeat	365..401	CDD:293791	11/36 (31%)
		WD40 repeat	408..433	CDD:293791	5/24 (21%)
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	90/410 (22%)
		WD40 repeat	295..344	CDD:293791	15/54 (28%)
		WD40 repeat	350..397	CDD:293791	13/46 (28%)
		WD40 repeat	400..473	CDD:293791	9/72 (13%)
		WD40 repeat	478..513	CDD:293791	10/57 (18%)
		WD40	<518..>593	CDD:295369	23/76 (30%)
		WD40 repeat	524..560	CDD:293791	11/36 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840