DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnai2 and Dnai3

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001128208.1	Gene:	Dnai3 / 292165	RGDID:	1563105	Length:	921	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	152/746 - (20%)
Similarity:	259/746 - (34%)	Gaps:	219/746 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YIFKKERRSFGARVHFEDKD-----EVVFTENSNPELVKSYILKNPVDRVTQYAGQTSLSVANTE 62
            |:..::|..|||.|.|.|::     :......|.|:  |||.|       ||......|.|.
  Rat   186 YMISRKRSQFGAPVTFRDQNASSVKDAYIECTSYPD--KSYTL-------TQVEKDIGLQVI--- 238

  Fly    63 RATYKSTGITHNEGGWPKDINMHDPEQTVRYKRKI-EKDENYITQVMNLTK-------PMEHYIH 119
             |..|.|. |.....:|::..      |..|.|:. |:::|.:.:..:|.:       .:|..:.
  Rat   239 -AEVKDTS-TQTRWAFPRNAT------TQYYPREFSEEEKNVLVESKSLAEFFSTVSTSVEIALQ 295

  Fly   120 QNNAVNIYENYFENLDPAPLPEPCKSRT-VNVYRD----PNPIKVPVKHLSWSPD--GGIKMAVS 177
            ||..:|.:.:.:.:|.........|:.| :..|:.    .|.::..:..:||.|.  |.|.::|:
  Rat   296 QNEIMNTFTDDWRSLAEEESTFGDKTDTHLKEYQSFTDLHNTMEKMITCVSWHPTIYGLIVVSVA 360

  Fly   178 HCDMRFQGDKSNQKCNSYI--------WEVENPNEPFLTLEPKVPCVCLEYNQKDPTSLVSGMYN 234
               :|...::..|..:..:        |...:|..|.|.||......|.|:...||..:..|..|
  Rat   361 ---VRLSYEERVQNSSRLLLQPSLILFWSFSDPIHPQLMLESPDDIFCFEFCPSDPNIIAGGCIN 422

  Fly   235 GQVAAWD-TRHGK-----------------LPVMI----SEREV-----C--------HRDPVNS 264
            ||:..|| |.|.:                 .|:.:    |.:|:     |        ||..:..
  Rat   423 GQIILWDITAHAERIENIKTGGSRSKKATLKPMFLLEPDSNKEIMYVRHCAVSSIENGHRKVITD 487

  Fly   265 VLW---------------NNSKSGTEFFSGGSDGQVLWWDTR--KLT------------------ 294
            :.|               |.|....:..:..:|..:.:||.|  |.|
  Rat   488 IHWLPDSFEINRMGSVFENRSGINCQLITCSADCTICFWDIRPQKPTVTSAATATTTSTTNTNPQ 552

  Fly   295 -----------------------------EPLDRLLMD---------PVK---SDDQDLSRSYGI 318
                                         :||.|:.:.         |.|   .:|..|.:..|.
  Rat   553 QPPAEKKKEESIEIPFDVPSTFLHLDLSWKPLSRIKLSKGETSLDHCPTKLSLGEDPALCKIQGT 617

  Fly   319 SVLE---------------------YET-------------TIPTRFMAGTEMGMLFSCNRK--- 346
            |.:.                     |:.             ...|:|..|||.|.:...:.|
  Rat   618 SSIHVLLRDKMLSQMKLLKAAEINPYQNLEGGMANMLKPIEDFRTKFFVGTEEGEVIYTDWKMER 682

  Fly   347 ----GKTPTEKIQIRMMCHLGPVYAITRNPAFVKNFLTVGDWCARIWSEDCRESSIIWTKSSSSM 407
                |:...:|.......|.|.|:.:.|:|.|....||||.|...||.|:.....::.|..:...
  Rat   683 DSETGRLMAKKPVNLYTVHDGAVHTVQRSPFFNDIILTVGGWNVAIWKEEVLTGPLLQTCCAPKR 747

  Fly   408 LTDGAWSYTKVSQFFITRMDGVLDTWDLLQQQNEPVLTVKVCDEPLYCVRT---NENGKFVSCGS 469
            .|.|.||.|:...|:|.|.||.:|.||||::.:||..:..:|...:..::.   :...:|::...
  Rat   748 YTAGHWSLTRPGVFYIGREDGYVDIWDLLEKTHEPAQSQSICITMITYIKPWTFSSKQQFIAIAD 812

  Fly   470 QLGATFLVEVSDNMVMSAKNDKPLLTAMFERE-------NRREKILEAKSRE---SKLKVKANHG 524
            ..|...::|:...:...:.|:...:...||||       .:|::|.|.:.:.   ..:|.||...
  Rat   813 YYGTLHILEIPWTLSHPSTNEVSSVNYYFEREVKHLEYVQQRKEIREEEKKAMAMEMIKKKAKTY 877

  Fly   525 QDQGDTMMVNGKINMAPFEAACEQAASEYFA 555
            ....:.|....|:.   :|:..|...|..||
  Rat   878 HRSKEQMEAELKLE---YESYLELEQSVLFA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	96/486 (20%)
		WD40 repeat	162..208	CDD:293791	11/55 (20%)
		WD40	212..469	CDD:295369	80/411 (19%)
		WD40 repeat	215..254	CDD:293791	14/60 (23%)
		WD40 repeat	262..304	CDD:293791	12/114 (11%)
		WD40 repeat	318..355	CDD:293791	11/77 (14%)
		WD40 repeat	365..401	CDD:293791	12/35 (34%)
		WD40 repeat	408..433	CDD:293791	11/24 (46%)
Dnai3	NP_001128208.1	WD40	207..>532	CDD:225201	69/347 (20%)
Dnai3	NP_001128208.1	WD40	479..527	CDD:197651	6/47 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56355
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820