DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnai2 and Sdic2

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001285481.1	Gene:	Sdic2 / 2768883	FlyBaseID:	FBgn0053497	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	104/444 - (23%)
Similarity:	188/444 - (42%)	Gaps:	69/444 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KDINMHDPEQTVRYKRKIEKDENYITQVMNLTKPMEHYIHQNNAVNIYENYFENLDPAPL-PEPC 143
            |::|....||    |:.|...||:...|:...:.:|..:.:|  |:||.:|....|.... .|..
  Fly   117 KEVNELSEEQ----KQMIILSENFQRFVVRAGRVIERALSEN--VDIYTDYIGGGDSEEANDERS 175

  Fly   144 KSR-TVN-VYRDPNPIKVP-VKHLSWSPDGGIKMAVSHCDMRFQGDKSNQKCNSYIWEVENPNEP 205
            .:| ::| |:.|....|.. :..:.||         :|......|...|.:        |:||||
  Fly   176 HARLSLNRVFYDERWSKNRCITSMDWS---------THFPELVVGSYHNNE--------ESPNEP 223

  Fly   206 ----------FLTLEPK--------VPCVCLEYNQKDPTSLVSGMYNGQVAAWDTR-HGKLPVMI 251
                      |....|:        |...|  :.:.:|..::.|.|:||:..||.| ..:.|:..
  Fly   224 DGVVMVWNTKFKKSTPEDVFHCQSAVMSTC--FAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQR 286

  Fly   252 SE-REVCHRDPVNSVLWNNSKSGTEFFSGGSDGQVLWWDTRKLTEPLDRLLMDPVKSDDQDLSRS 315
            :. ....|..||..:....:::.....|..|||::..|....|::|.|.|.:      .|..|::
  Fly   287 TPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLEL------QQRQSKA 345

  Fly   316 YGISVLEYETTIPTRFMAGTEMGMLFSCNRKG-KTPTEKIQIRMMCHLGPVYAITR-----NPAF 374
            ..|:.:.:........:.|:|.|.::|.:|.| ::...::..|   ||||:..|:.     :|.|
  Fly   346 IAITSMAFPANEINSVVMGSEDGYVYSASRHGLRSGVNEVYER---HLGPITGISTHYNQLSPDF 407

  Fly   375 VKNFLTVG-DWCARIWSEDCRESSIIWT-KSSSSMLTDGAWSYTKVSQFFITRMDGVLDTWDLLQ 437
            ...|||.. ||..::||  .:::..::: :.:|..:.|.|||....:.|......|.||.|:|.|
  Fly   408 GHLFLTSSIDWTIKLWS--LKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQ 470

  Fly   438 QQNEPVLTVKVCDEP-LYCVRTNENGKFVSCGSQLGATFLVEVSDNMVMSAKND 490
            ....|..::.|...| |..|....:|..|..|.:.|..::.:|::|:...::::
  Fly   471 DTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	81/351 (23%)
		WD40 repeat	162..208	CDD:293791	11/55 (20%)
		WD40	212..469	CDD:295369	66/275 (24%)
		WD40 repeat	215..254	CDD:293791	10/40 (25%)
		WD40 repeat	262..304	CDD:293791	10/41 (24%)
		WD40 repeat	318..355	CDD:293791	7/37 (19%)
		WD40 repeat	365..401	CDD:293791	10/41 (24%)
		WD40 repeat	408..433	CDD:293791	8/24 (33%)
Sdic2	NP_001285481.1	Dynein_IC2	23..51	CDD:288403
		NtpH	108..>178	CDD:225368	17/66 (26%)
		WD40	196..512	CDD:295369	80/345 (23%)
		WD40 repeat	196..245	CDD:293791	12/65 (18%)
		WD40	<224..523	CDD:225201	72/311 (23%)
		WD40 repeat	251..289	CDD:293791	10/39 (26%)
		WD40 repeat	298..337	CDD:293791	9/38 (24%)
		WD40 repeat	349..435	CDD:293791	21/90 (23%)
		WD40 repeat	441..479	CDD:293791	12/37 (32%)
		WD40 repeat	487..513	CDD:293791	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840