DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dnai2 and DYNC1I1

DIOPT Version :10

Sequence 1:NP_001261723.1 Gene:Dnai2 / 39318 FlyBaseID:FBgn0036195 Length:585 Species:Drosophila melanogaster
Sequence 2:NP_004402.1 Gene:DYNC1I1 / 1780 HGNCID:2963 Length:645 Species:Homo sapiens


Alignment Length:536 Identity:116/536 - (21%)
Similarity:202/536 - (37%) Gaps:109/536 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DKDEVVFTENSNPELVKSYILKNPVDRVTQ----------YAGQTSLSVANTERATYKS------ 68
            |.|..|....|:.||.:. :.|..|.:|||          |:.:|     .|..||::|      
Human   127 DTDPSVLQLQSDSELGRR-LHKLGVSKVTQVDFLPREVVSYSKET-----QTPLATHQSEEDEED 185

  Fly    69 TGITHNEGGWPKDINMHDPEQTVRYKRKIEKDENYITQVMNLTKPMEHYIHQNNAVNIYENYF-E 132
            ..:..::.|...::...|.:|.|:.....|..|....|:::   ..|..|..:..:.:.|... |
Human   186 EEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILH---SEEFLIFFDRTIRVIERALAE 247

  Fly   133 NLDPAPLPEPCKSRTVNVYRDPNPIKVPVK--------HLS---------WSPDGGIKMAVSHCD 180
            :.|              ::.|.:..::..|        :||         ||     |..|..| 
Human   248 DSD--------------IFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWS-----KHRVVTC- 292

  Fly   181 MRFQGDKSNQKCNSYIWEVENPNEP----------FLTLEPK--------VPCVCLEYNQKDPTS 227
            |.:..........||....:.|:||          |....|:        |..||  :.:..|..
Human   293 MDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVC--FARFHPNL 355

  Fly   228 LVSGMYNGQVAAWDTR-HGKLPVMISE-REVCHRDPVNSVLWNNSKSGTEFFSGGSDGQVLWWDT 290
            :|.|.|:||:..||.| |.:.||..:. ....|..||..|....:::.....:..:||::..|..
Human   356 VVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSL 420

  Fly   291 RKLTEPLDRLLMDPVKSDDQDLSRSYGISVLEYETTIPTRFMAGTEMGMLFSCNRKGKTPTEKIQ 355
            ..|:.|.:.:.:...|      |:...::.:.:.|.....|:.|:|.|.:::..|.|    .|..
Human   421 DMLSTPQESMELVYNK------SKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHG----SKAG 475

  Fly   356 IRMMC--HLGPVYAITRNPA-----FVKNFLTVG-DWCARIWSEDCRESSIIWT-KSSSSMLTDG 411
            |..:.  |.|||..|..:.|     |...|:|.. ||..::|:  .:.:..::: :.::..:.|.
Human   476 IGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWT--TKHNKPLYSFEDNADYVYDV 538

  Fly   412 AWSYTKVSQFFITRMDGVLDTWDLLQQQNEPVLTVKV-CDEPLYCVRTNENGKFVSCGSQLGATF 475
            .||....:.|......|.||.|:|......|..:|.: ....|..||..:.||.|:.|...|..:
Human   539 MWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIW 603

  Fly   476 LVEVSDNMVMSAKNDK 491
            :.:|.:..|  ..||:
Human   604 VYDVGELAV--PHNDE 617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dnai2NP_001261723.1 WD40 212..469 CDD:475233 64/276 (23%)
WD40 repeat 215..254 CDD:293791 14/40 (35%)
WD40 repeat 262..304 CDD:293791 7/41 (17%)
WD40 repeat 318..355 CDD:293791 8/36 (22%)
WD40 repeat 365..401 CDD:293791 9/41 (22%)
WD40 repeat 408..433 CDD:293791 7/24 (29%)
WD40 repeat 162..208 CDD:293791 15/72 (21%)
DYNC1I1NP_004402.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Interaction with DCTN1. /evidence=ECO:0000250 2..123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..125
Dynein_IC2 143..173 CDD:463291 7/35 (20%)
Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274 147..163 5/15 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..221 11/56 (20%)
WD 1 285..334 11/54 (20%)
WD40 repeat 291..337 CDD:293791 9/46 (20%)
WD40 <318..607 CDD:441893 68/302 (23%)
WD 2 338..378 13/41 (32%)
WD40 repeat 346..385 CDD:293791 14/40 (35%)
WD 3 387..428 9/40 (23%)
WD40 repeat 393..434 CDD:293791 6/40 (15%)
WD 4 437..477 9/43 (21%)
WD40 repeat 442..481 CDD:293791 9/42 (21%)
WD 5 482..527 12/46 (26%)
WD40 repeat 488..529 CDD:293791 8/42 (19%)
WD 6 530..570 9/39 (23%)
WD40 repeat 535..573 CDD:293791 10/37 (27%)
WD 7 576..615 10/40 (25%)
WD40 repeat 581..607 CDD:293791 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

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