DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnai2 and dnai3

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_017209145.2	Gene:	dnai3 / 100333131	ZFINID:	ZDB-GENE-121116-5	Length:	968	Species:	Danio rerio

Alignment Length:	735	Identity:	139/735 - (18%)
Similarity:	247/735 - (33%)	Gaps:	238/735 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRSFGARVHFEDKDEVVFTENSNPELVK--SYILKNPVDRVTQYAGQTSLSVANTER--ATYKST 69
            ||| |.||.|.|::.:.:.|    |||:  ||..|             |.|:...||  :|....
Zfish   202 RRS-GTRVRFSDRNALDWKE----ELVECSSYEDK-------------SFSITRMERDSSTQTCR 248

  Fly    70 GITH--NEGGWPKDINM---HDP----EQTVRYKRKIEKDENYITQVMNLTKPMEHYIHQNNAVN 125
            ..||  .:..|.|..||   ::|    .:..:::.:.|..:|:||.|   .:..|.|:.||...:
Zfish   249 DNTHTCTQTLWKKPKNMWSQYEPREFSSEEKQHQLQSENLKNFITSV---ARRFEIYLQQNLIAD 310

  Fly   126 IYENYFENL--DPAPLPEPCKSRTVNVYRDPNPI----KVPVKHLSWSPDGGIKMAVS---HCDM 181
            ::.:.:..|  |.|.|....::: :..|:....:    :..:.|:.|.|.....:.||   ...:
Zfish   311 VFCDDWTALCEDDASLMGKTETQ-LKEYQSFMDLHFSKEKTISHVQWHPSISGVIVVSMMERLSL 374

  Fly   182 RFQGDKSNQ----KCNSYIWEVENPNEPFLTLEPKVPCVCLEYNQKDPTSLVSGMYNGQVAAW-- 240
            ..:.|.|.:    ..:...|...:|..|.|.||.....:|.:::..|...:..|..||||..|
Zfish   375 EERIDSSTKLLLNPSHILFWSFSDPINPQLQLECPDDVLCFQFSPSDHNIIAGGCMNGQVVLWDI 439

  Fly   241 --------DTRHG------KL------PVM----ISEREVCHRDPVNSVLW-------------- 267
                    |||.|      ||      ||:    :|..|..|:.|:..:.|
Zfish   440 SAHVDRLQDTRSGGKNILNKLGKSDATPVVRYCAVSGIENGHKAPITDIQWLPETFEVNKLGTPV 504

  Fly   268 -NNSKSGTEFFSGGSDGQVLWWDTRKLTEPLDRLLMDPVKSDDQDLSRSYGI------------- 318
             |.|::..:..:...|..||:||.|.....:..|.....|.:::.|...:|:
Zfish   505 ENQSRTSVQLVTCAPDCCVLFWDLRAPRVMVHSLTDIKQKQEEKPLENPHGVPNTFTHLNLTWKP 569

  Fly   319 ------------------------SVLEYET----------------------------TIPTRF 331
                                    :.::|.|                            .|.|:.
Zfish   570 FIRVSLPKISSSGEYSPLRFSMRENTVDYNTGDKSVSGADSRVFAQLRMQSAKQQKPLQNISTKL 634

  Fly   332 MAGTEMGMLF-------SCNRKGKTPTEKIQIRMMCHLGPVYAITRNPAFVKNFLTVGDWCARIW 389
            ...||.|.|.       ..|..|:..:.|.....:.....::.::|:|.|....||||.:...||
Zfish   635 YIATEDGELVYTDWKVEKDNDSGRMLSAKPLDVFLLQDTLLHTVSRSPFFRDIILTVGRFSFSIW 699

  Fly   390 SEDCRESSIIWTKSSSSMLTDGAWSYTKVSQFFITRMDGVLDTWDLLQQQNEPVLTVKVCDEPLY 454
            .|......::.:..|.||.:.|.||.::.:..|:.|.||.::.|||||...:|..|..:....:.
Zfish   700 REGLTCGPLLMSVYSKSMFSAGHWSRSRPAVLFMGREDGDVEVWDLLQNSRQPSHTQNISTAAIS 764

  Fly   455 CVRTNENG--------------------------------------------------------- 462
            |:||..:.
Zfish   765 CIRTQTSSGNTHPYTETLHTHTHTQPPSAAYAHRPAPVTHTHTHKHCTHTHTHTHTHTHTHSRHQ 829

  Fly   463 --------------------KFVSCGSQLGATFLVEVSDNMVMSAKNDKPLLTAMFERENRREKI 507
                                ..::...:||...::::..::..|:.:::..:...||:|..|.:.
Zfish   830 LHTHTDQLRVLEERVREAKQNLLAVSDRLGTLHILQIPGSLRRSSSSERQNVEKYFEKEEERLQY 894

  Fly   508 LEAKSRESKLKVKANHGQDQ 527
            .|.:..:.:.|.|....:.|
Zfish   895 FEKRQSDHQKKKKETEAEQQ 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	89/518 (17%)
		WD40 repeat	162..208	CDD:293791	10/52 (19%)
		WD40	212..469	CDD:295369	74/446 (17%)
		WD40 repeat	215..254	CDD:293791	17/64 (27%)
		WD40 repeat	262..304	CDD:293791	10/56 (18%)
		WD40 repeat	318..355	CDD:293791	11/108 (10%)
		WD40 repeat	365..401	CDD:293791	10/35 (29%)
		WD40 repeat	408..433	CDD:293791	7/24 (29%)
dnai3	XP_017209145.2	WD40	<348..>533	CDD:225201	42/184 (23%)
dnai3	XP_017209145.2	SbcC	<835..>953	CDD:223496	11/80 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56355
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920