DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnai2 and dnai3

DIOPT Version :9

Sequence 1:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001120428.1	Gene:	dnai3 / 100145513	XenbaseID:	XB-GENE-980327	Length:	896	Species:	Xenopus tropicalis

Alignment Length:	727	Identity:	151/727 - (20%)
Similarity:	260/727 - (35%)	Gaps:	210/727 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEYIFKKERRSFGARVHFEDKDEVVFTENSNPELVKSYILKNPVDRVTQYAGQTSLSVANTERAT 65
            ::::..:.:|.|||:|:|.|       .|::.       :|:.....|.|..: ..|:...||.|
Frog   193 IKFMISRIQRKFGAKVNFGD-------HNASD-------VKDGYMECTSYQDK-RFSIKINERDT 242

  Fly    66 ------YKSTGITHNEGGWPKD-INMHDPEQTVRYKRKI---EKD-ENYITQVMNLTKPMEHYIH 119
                  :.....|..:.|:|:: ...:.|.:....:||.   .|| ::::..|   :..:|..:.
Frog   243 GIQVVPFTQENSTQTKWGYPRNACTQYTPREFTEEERKACLSSKDFKDFVNSV---SLRLELALQ 304

  Fly   120 QNNAVNIY----------ENYFENLDPAPLPEPCKSRTVNVYRDPNPIKVPVKHLSWSPDGGIKM 174
            ||..:|.:          ||.|.....:.|.| .:|.|.:::.:...|    ..::|.|.....:
Frog   305 QNEIMNAFLDDWKALSEEENTFGGKSDSHLKE-SQSFTDHLFSNAKTI----SGINWHPKIHGLV 364

  Fly   175 AVSHCDMRFQGDKSNQKCNSYI-------WEVENPNEPFLTLEPKVPCVCLEYNQKDPTSLVSGM 232
            |||..:.....|:.|......:       |...:|..|.|.||......|.::...||..:..|.
Frog   365 AVSMTERLSFEDRVNISSKILLKPSLILFWSFTDPLHPQLMLECPDDIYCFQFCPSDPNIIAGGC 429

  Fly   233 YNGQVAAWDTRHGKLPVM------------------------------ISEREVCHRDPVNSVLW 267
            :||||..||....:..:|                              :|..|..|::.:..:.|
Frog   430 FNGQVVLWDISKYQESLMAKAGVSKNTAPKTGLEPSVPKGPQLVRYCAVSSIEHGHKNVITDIHW 494

  Fly   268 --NN-----------SKSG--TEFFSGGSDGQVLWWDTRKLTEPLDRLLMDPVKSDDQDLSRSYG 317
              ||           :|||  .:..:...|..:::||.|.     .:.|....|.:.:|....:|
Frog   495 LPNNFELSNAGNPYENKSGYCLQLVTCSPDCSIMFWDIRP-----QKTLTAAEKKNVEDKQMPHG 554

  Fly   318 I----------------------------------------------------------SVLEYE 324
            :                                                          .|:||:
Frog   555 VPDTFKYIDLTWRPFIRAILPKSDMSGEYSPMKISLSEEHHHCRTLDKLQIQAKEDKTEGVVEYK 619

  Fly   325 T-------------TIPTRFMAGTEMGMLFSCNRK-------GKTPTEKIQIRMMCHLGPVYAIT 369
            :             .|.|::..|||.|.|...:.|       ||..:.|.....:.|.|.|..:.
Frog   620 SLRAASAKNPKLLDDINTKYFVGTEDGELVYTDWKMEKDSDTGKLISSKPLQANILHDGAVNTVQ 684

  Fly   370 RNPAFVKNF-LTVGDWCARIWSEDCRESSIIWTKSSSSMLTDGAWSYTKVSQFFITRMDGVLDTW 433
            |:| |:|:| ||||.|...||.|......|..:..|...||...||.::...|||.:.||.:|.|
Frog   685 RSP-FLKDFILTVGGWNFAIWREGVTSGPIFHSCCSQKRLTAAHWSLSRTGVFFIGKEDGNVDVW 748

  Fly   434 DLLQQQNEPVLTVKVCDEPLYCVR---TNENGKFVSCGSQLGATFLVEVSDNMVMSAKNDKPLLT 495
            |||::.:||..|..:...|:..:|   .:....|::.|...|...::|:..|:...:.|:...:.
Frog   749 DLLEKTHEPSQTQNIAAAPITYIRPWIASSKQHFLAVGDDQGTLHILEIPWNLRHPSANENASVQ 813

  Fly   496 AMFERE-------NRREKILEAKSRESKLKVKANHGQDQGDTMMVNGKINMAPFEAACEQAASEY 553
            ..||||       |:||.:.....::.:||             .::.|...:|.....||
Frog   814 HYFEREVKHVEYSNQREGLRATAKKQLELK-------------DLSAKTETSPPVKTKEQ----- 860

  Fly   554 FAAVEQERQRRL 565
             ..|||.::..|
Frog   861 -TEVEQSKEYEL 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	96/455 (21%)
		WD40 repeat	162..208	CDD:293791	10/52 (19%)
		WD40	212..469	CDD:295369	80/383 (21%)
		WD40 repeat	215..254	CDD:293791	12/68 (18%)
		WD40 repeat	262..304	CDD:293791	11/56 (20%)
		WD40 repeat	318..355	CDD:293791	14/114 (12%)
		WD40 repeat	365..401	CDD:293791	15/36 (42%)
		WD40 repeat	408..433	CDD:293791	10/24 (42%)
dnai3	NP_001120428.1	WD40	<343..>548	CDD:225201	40/213 (19%)
		WD40 repeat	723..763	CDD:293791	17/39 (44%)
		WD40 repeat	769..814	CDD:293791	7/44 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56355
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920