DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dph1 and dph1

DIOPT Version :9

Sequence 1:	NP_001261722.1	Gene:	Dph1 / 39317	FlyBaseID:	FBgn0036194	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_005157638.1	Gene:	dph1 / 550559	ZFINID:	ZDB-GENE-050417-411	Length:	439	Species:	Danio rerio

Alignment Length:	428	Identity:	252/428 - (58%)
Similarity:	316/428 - (73%)	Gaps:	27/428 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SESTDIVVVRARPKKVFKPKARINRIPQELLDDPLLQQAIDRLPSNYNFEMHKTIWRIREMKAKR 78
            :.|:::.|:.|:...|..|:...|:||:|:|.|..|.:||..||:|||||:||||||:|:.||||
Zfish    18 ASSSELEVITAKKPNVKGPRRVANQIPEEILKDSDLNEAIKALPANYNFEIHKTIWRVRQAKAKR 82

  Fly    79 VALQLPEGLLMYAMVISDIVERFTSADTVIMGDVTYGACCVDDYTAKALGADLLVHYGHSCLIPV 143
            |||||||||.|:|.||:||:||||.|||::|||||||||||||:||:|||||.:||||||||||:
Zfish    83 VALQLPEGLQMFACVIADIIERFTEADTLVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPI 147

  Fly   144 DQTCGIKVLYIFVDIKIDPLHFLDSVKLNFRPEVGQ-IALVSTIQFVTTLQAASTELKAAGYDVI 207
            |.|.|||:||:||||:||..||||:::.||.|  |: :|||||||||..|||||..|| ..|:|:
Zfish   148 DSTEGIKMLYVFVDIQIDTAHFLDTLRFNFPP--GRSLALVSTIQFVAALQAASAALK-PDYEVL 209

  Fly   208 VPQAKPLSPGEILGCTSPQLPETTKMIIYLGDGRFHLESAMIANPLLKAYKYDPYEKKFTTEQYD 272
            |||.:|||||||||||||:|.:....:||||||||||||.|||||...||:||||.|.|:.|.||
Zfish   210 VPQCRPLSPGEILGCTSPRLDKHVNAVIYLGDGRFHLESIMIANPDTPAYRYDPYSKVFSREYYD 274

  Fly   273 HSAMQNLRLDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGIETTTLLLSEIFPQKLA 337
            |.||:..||.|::.|:.|:|.|:|||||||||:.::...||.:|.:.|...|.:|||||||:||.
Zfish   275 HDAMRATRLKAIESARSAQRWGLILGTLGRQGNPKILEHLESQLKSLGRSFTRVLLSEIFPRKLE 339

  Fly   338 LFADIDAFVQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPRNNAYPMDFYASGSL 402
            |.||:||:|||||||||||||:|||:|||:|||.:|.|..|.|        .:.||||||::.||
Zfish   340 LLADVDAWVQIACPRLSIDWGTAFSKPLLSPYEAAVALQQVGW--------QDVYPMDFYSNQSL 396

  Fly   403 GPWTPNF-----KPPA----------IGECENKPSADC 425
            |.||||.     |.||          :..|..:.||.|
Zfish   397 GAWTPNHPDNQPKRPARKTAQKAGQQVISCGQEQSASC 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dph1	NP_001261722.1	Diphthamide_syn	83..380	CDD:280107	195/297 (66%)
dph1	XP_005157638.1	Diphthamide_syn	87..382	CDD:280107	195/297 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582727
Domainoid	1	1.000	340	1.000	Domainoid score	I1062
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1059
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1816
OMA	1	1.010	-	-		QHG62277
OrthoDB	1	1.010	-	-		D300951at33208
OrthoFinder	1	1.000	-	-		FOG0003904
OrthoInspector	1	1.000	-	-		oto38728
orthoMCL	1	0.900	-	-		OOG6_101267
Panther	1	1.100	-	-	LDO	PTHR10762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2688
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910