DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dph1 and Dph1

DIOPT Version :9

Sequence 1:	NP_001261722.1	Gene:	Dph1 / 39317	FlyBaseID:	FBgn0036194	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001099279.1	Gene:	Dph1 / 287523	RGDID:	1562694	Length:	438	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	241/451 - (53%)
Similarity:	308/451 - (68%)	Gaps:	39/451 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLDVIQPSSNLPTSESTDIVVVRARPKKVFKPKARI-NRIPQELLDDPLLQQAIDRLPSNYNFEM 64
            |..::.|.::.|.|        |..|.:....:.|: |:||.|:|:.|.||.|:..||||||||:
  Rat     1 MAALVVPETSEPGS--------RVGPGRGRISRGRLANQIPPEILNSPQLQAAVHALPSNYNFEI 57

  Fly    65 HKTIWRIREMKAKRVALQLPEGLLMYAMVISDIVERFTSADTVIMGDVTYGACCVDDYTAKALGA 129
            .||||||::.:||:||||:|||||::|..|.||:||||.|:.::|||||||||||||:||:|||.
  Rat    58 PKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTKAEVMVMGDVTYGACCVDDFTARALGV 122

  Fly   130 DLLVHYGHSCLIPVDQTC-GIKVLYIFVDIKIDPLHFLDSVKLNFRPEVGQIALVSTIQFVTTLQ 193
            |.|||||||||:|:|.:. ..:|||:||||:||..|.||||:|.|.|. ..:|||||||||:|||
  Rat   123 DFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFTPG-SSLALVSTIQFVSTLQ 186

  Fly   194 AASTELKAAGYDVIVPQAKPLSPGEILGCTSPQLPETTKMIIYLGDGRFHLESAMIANPLLKAYK 258
            ||:.||| |.|.:.|||.||||||||||||||:||:..:.::|||||||||||.|||||.:.:|:
  Rat   187 AAAQELK-ADYHISVPQCKPLSPGEILGCTSPRLPKEVEAVVYLGDGRFHLESVMIANPNIPSYR 250

  Fly   259 YDPYEKKFTTEQYDHSAMQNLRLDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGIET 323
            ||||.|..:.|.|||..||..|.:|:..|:.|:..|:||||||||||.:|...||.:|...|:..
  Rat   251 YDPYSKVLSREYYDHQRMQATRQEAIAAARSAKFWGLILGTLGRQGSPKVLEHLESQLRNLGLPF 315

  Fly   324 TTLLLSEIFPQKLALFADIDAFVQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPR 388
            ..||||||||.||:|...:|.:||:|||||||||||||.:|||.|||.:|.|.::.|
  Rat   316 LRLLLSEIFPSKLSLLPSVDVWVQVACPRLSIDWGSAFPKPLLTPYEAAVALKEISW-------- 372

  Fly   389 NNAYPMDFYASGSLGPWTPNF---KPPAIGECENKPSAD-------------CCGRCTRAE 433
            ...|||||||..||||||.|.   :.|. |.|:  |::|             .|..|:.|:
  Rat   373 QQPYPMDFYAGSSLGPWTVNHGRDRAPR-GLCQ--PASDKVQQGSRGHSPVPACEGCSCAD 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dph1	NP_001261722.1	Diphthamide_syn	83..380	CDD:280107	182/297 (61%)
Dph1	NP_001099279.1	Diphthamide_syn	76..372	CDD:280107	186/296 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342690
Domainoid	1	1.000	375	1.000	Domainoid score	I841
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1059
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1512
OMA	1	1.010	-	-		QHG62277
OrthoDB	1	1.010	-	-		D300951at33208
OrthoFinder	1	1.000	-	-		FOG0003904
OrthoInspector	1	1.000	-	-		oto98572
orthoMCL	1	0.900	-	-		OOG6_101267
Panther	1	1.100	-	-	LDO	PTHR10762
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2688
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910