DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dph1 and SPBC3B8.05

DIOPT Version :9

Sequence 1:	NP_001261722.1	Gene:	Dph1 / 39317	FlyBaseID:	FBgn0036194	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_596409.1	Gene:	SPBC3B8.05 / 2540295	PomBaseID:	SPBC3B8.05	Length:	436	Species:	Schizosaccharomyces pombe

Alignment Length:	425	Identity:	222/425 - (52%)
Similarity:	287/425 - (67%)	Gaps:	34/425 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SNLPTS----ESTDIVVVRARPKKVFKPKARI-NRIPQELLDDPLLQQAIDRLPSNYNFEMHKTI 68
            :||..|    |:..:|.:.::     :...|: .:||:::|:|..:.:||..||.|||||:||||
pombe    22 NNLDGSNRDVENAALVTINSK-----RSAGRVATQIPEDILNDKAINEAIKLLPQNYNFEIHKTI 81

  Fly    69 WRIREMKAKRVALQLPEGLLMYAMVISDIVERFTSADTVIMGDVTYGACCVDDYTAKALGADLLV 133
            |.||..|||||||||||||||:..::|||.|:|...:|::||||||||||:||:||:||..|.||
pombe    82 WHIRLRKAKRVALQLPEGLLMFGCILSDIFEQFCQVETIVMGDVTYGACCIDDFTARALDCDFLV 146

  Fly   134 HYGHSCLIPVDQTCGIKVLYIFVDIKIDPLHFLDSVKLNFRPEVGQIALVSTIQFVTTLQAASTE 198
            ||||||||||||| .|||||:|||||||..|.:.|:|.|. |...::|||.|||||.:|.:....
pombe   147 HYGHSCLIPVDQT-PIKVLYVFVDIKIDLQHVVSSLKHNL-PSNSRLALVGTIQFVGSLNSIKDA 209

  Fly   199 LK------AAGYDVIVPQAKPLSPGEILGCTSPQLPE-TTKMIIYLGDGRFHLESAMIANPLLKA 256
            |:      ..|:.|::||||||||||.||||||.:.: :...:||:|||||||||.|||||.|.|
pombe   210 LQIQDEDGKGGFYVVIPQAKPLSPGEALGCTSPYIEKGSVDALIYIGDGRFHLESVMIANPDLPA 274

  Fly   257 YKYDPYEKKFTTEQYDHSAMQNLRLDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGI 321
            |:||||..|.:.|.|.|..|:::|..||::|:.|::.|:|.||||||||.:|...|:..|.....
pombe   275 YRYDPYSHKLSIESYAHEEMKSIRYSAVEKARTAKKFGLIQGTLGRQGSPKVLENLKNTLRKNNK 339

  Fly   322 ETTTLLLSEIFPQKLALFADIDAFVQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSS 386
            :...:|:|||||.:|..|:||||::|:||||||||||.||..|||.|||.|.....|.|
pombe   340 DFVCVLMSEIFPSRLGQFSDIDAWIQVACPRLSIDWGYAFPAPLLTPYEASAAFNVVPW------ 398

  Fly   387 PRNNAYPMDFYASGSLGPWTPNFKPPAIGECENKP 421
              ...|||||||:.|||.|||| .|      ||:|
pombe   399 --KEVYPMDFYATNSLGNWTPN-NP------ENRP 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dph1	NP_001261722.1	Diphthamide_syn	83..380	CDD:280107	169/303 (56%)
SPBC3B8.05	NP_596409.1	Diphthamide_syn	96..398	CDD:280107	169/303 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	341	1.000	Domainoid score	I192
eggNOG	1	0.900	-	-		E1_COG1736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1059
Inparanoid	1	1.050	424	1.000	Inparanoid score	I336
OMA	1	1.010	-	-		QHG62277
OrthoFinder	1	1.000	-	-		FOG0003904
OrthoInspector	1	1.000	-	-		oto102014
orthoMCL	1	0.900	-	-		OOG6_101267
Panther	1	1.100	-	-	LDO	PTHR10762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R336
SonicParanoid	1	1.000	-	-		X2688
TreeFam	1	0.960	-	-
	14	13.860