Protein Alignment Dph1 and DPH1

DIOPT Version :10

• Sequence 1: NP_648496.1
• Gene: Dph1 / 39317
• FlyBaseID: FBgn0036194
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001374.4
• Gene: DPH1 / 1801
• HGNCID: 3003
• Length: 438
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 243/423 - (57%)
• Similarity: 302/423 - (71%)
• Gaps: 25/423 - (5%)

  Fly    23 RARPKKVFKPKARI-NRIPQELLDDPLLQQAIDRLPSNYNFEMHKTIWRIREMKAKRVALQLPEG 86
            |..|.:...|:.|: |:||.|:|.:|.||.||..||||||||:.||||||::.:||:||||:|||
Human    15 RDGPGRGRAPRGRVANQIPPEILKNPQLQAAIRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEG 79

  Fly    87 LLMYAMVISDIVERFTSADTVIMGDVTYGACCVDDYTAKALGADLLVHYGHSCLIPVDQTC-GIK 150
            ||::|..|.||:||||.|:.::|||||||||||||:||:|||||.|||||||||||:|.:. ..:
Human    80 LLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFR 144

  Fly   151 VLYIFVDIKIDPLHFLDSVKLNFRPEVGQIALVSTIQFVTTLQAASTELKAAGYDVIVPQAKPLS 215
            |||:||||:||..|.|||::|.|.|... :|||||||||:|||||:.||||. |.|.|||.||||
Human   145 VLYVFVDIRIDTTHLLDSLRLTFPPATA-LALVSTIQFVSTLQAAAQELKAE-YRVSVPQCKPLS 207

  Fly   216 PGEILGCTSPQLPETTKMIIYLGDGRFHLESAMIANPLLKAYKYDPYEKKFTTEQYDHSAMQNLR 280
            ||||||||||:|.:..:.::|||||||||||.|||||.:.||:||||.|..:.|.|||..||..|
Human   208 PGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAAR 272

  Fly   281 LDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGIETTTLLLSEIFPQKLALFADIDAF 345
            .:|:..|:.|:..|:||||||||||.::...||.||.|.|:....||||||||.||:|..::|.:
Human   273 QEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPEVDVW 337

  Fly   346 VQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPRNNAYPMDFYASGSLGPWTPNF- 409
            ||:||||||||||:||.:|||.|||.:|.|.|:.|        ...|||||||..||||||.|.
Human   338 VQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--------QQPYPMDFYAGSSLGPWTVNHG 394

  Fly   410 ---KP-----PAIGECE----NKPSADCCGRCT 430
               :|     ||.|:.:    ..|||..|..|:
Human   395 QDRRPHAPGRPARGKVQEGSARPPSAVACEDCS 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dph1	NP_648496.1	Diphthamide_syn	83..381	CDD:460365	185/298 (62%)
DPH1	NP_001374.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	7..29		4/13 (31%)
		Diphthamide_syn	76..377	CDD:460365	186/310 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..421		7/29 (24%)