DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dph1 and DPH1

DIOPT Version :9

Sequence 1:	NP_001261722.1	Gene:	Dph1 / 39317	FlyBaseID:	FBgn0036194	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001374.4	Gene:	DPH1 / 1801	HGNCID:	3003	Length:	438	Species:	Homo sapiens

Alignment Length:	423	Identity:	243/423 - (57%)
Similarity:	302/423 - (71%)	Gaps:	25/423 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RARPKKVFKPKARI-NRIPQELLDDPLLQQAIDRLPSNYNFEMHKTIWRIREMKAKRVALQLPEG 86
            |..|.:...|:.|: |:||.|:|.:|.||.||..||||||||:.||||||::.:||:||||:|||
Human    15 RDGPGRGRAPRGRVANQIPPEILKNPQLQAAIRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEG 79

  Fly    87 LLMYAMVISDIVERFTSADTVIMGDVTYGACCVDDYTAKALGADLLVHYGHSCLIPVDQTC-GIK 150
            ||::|..|.||:||||.|:.::|||||||||||||:||:|||||.|||||||||||:|.:. ..:
Human    80 LLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFR 144

  Fly   151 VLYIFVDIKIDPLHFLDSVKLNFRPEVGQIALVSTIQFVTTLQAASTELKAAGYDVIVPQAKPLS 215
            |||:||||:||..|.|||::|.|.|... :|||||||||:|||||:.||||. |.|.|||.||||
Human   145 VLYVFVDIRIDTTHLLDSLRLTFPPATA-LALVSTIQFVSTLQAAAQELKAE-YRVSVPQCKPLS 207

  Fly   216 PGEILGCTSPQLPETTKMIIYLGDGRFHLESAMIANPLLKAYKYDPYEKKFTTEQYDHSAMQNLR 280
            ||||||||||:|.:..:.::|||||||||||.|||||.:.||:||||.|..:.|.|||..||..|
Human   208 PGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAAR 272

  Fly   281 LDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGIETTTLLLSEIFPQKLALFADIDAF 345
            .:|:..|:.|:..|:||||||||||.::...||.||.|.|:....||||||||.||:|..::|.:
Human   273 QEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPEVDVW 337

  Fly   346 VQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPRNNAYPMDFYASGSLGPWTPNF- 409
            ||:||||||||||:||.:|||.|||.:|.|.|:.|        ...|||||||..||||||.|.
Human   338 VQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--------QQPYPMDFYAGSSLGPWTVNHG 394

  Fly   410 ---KP-----PAIGECE----NKPSADCCGRCT 430
               :|     ||.|:.:    ..|||..|..|:
Human   395 QDRRPHAPGRPARGKVQEGSARPPSAVACEDCS 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dph1	NP_001261722.1	Diphthamide_syn	83..380	CDD:280107	185/297 (62%)
DPH1	NP_001374.4	Diphthamide_syn	76..377	CDD:376632	186/310 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148796
Domainoid	1	1.000	380	1.000	Domainoid score	I845
eggNOG	1	0.900	-	-		E1_COG1736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1059
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1539
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62277
OrthoDB	1	1.010	-	-		D300951at33208
OrthoFinder	1	1.000	-	-		FOG0003904
OrthoInspector	1	1.000	-	-		oto91494
orthoMCL	1	0.900	-	-		OOG6_101267
Panther	1	1.100	-	-	LDO	PTHR10762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R336
SonicParanoid	1	1.000	-	-		X2688
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800