DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dph1 and dph-1

DIOPT Version :9

Sequence 1:	NP_001261722.1	Gene:	Dph1 / 39317	FlyBaseID:	FBgn0036194	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_497750.1	Gene:	dph-1 / 175475	WormBaseID:	WBGene00007576	Length:	396	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	201/378 - (53%)
Similarity:	280/378 - (74%)	Gaps:	14/378 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RINRIPQELLDDPLLQQAIDRLPSNYNFEMHKTIWRIREMKAKRVALQLPEGLLMYAMVISDIVE 99
            :|:.:.:|:.::|.|::.:..|||||.||:.||||:||..::|.||||.||||:|||.||:||:|
Worm     7 QISTLVEEIANNPNLKEDLKILPSNYTFEVPKTIWKIRSTESKYVALQFPEGLIMYACVIADILE 71

  Fly   100 RFTSADTVIMGDVTYGACCVDDYTAKALGADLLVHYGHSCLIPVDQTCGIKVLYIFVDIKIDPLH 164
            ::|..|||||||||||||||||||||::|.|||||||||||:|:..|.||.:||:||:|.|:..|
Worm    72 KYTGCDTVIMGDVTYGACCVDDYTAKSMGCDLLVHYGHSCLVPIQNTDGIAMLYVFVNIHINLSH 136

  Fly   165 FLDSVKLNFRPEVGQIALVSTIQFVTTLQAASTELKA--AGYDVIVPQAKPLSPGEILGCTSPQL 227
            .:|.||.||:.:  ::.:|||:||:.:||...|....  :...:.:||.|||||||:||||||:|
Worm   137 LIDCVKENFQGK--RLVVVSTVQFIPSLQTLRTTFNKDDSSIRIDIPQCKPLSPGEVLGCTSPRL 199

  Fly   228 PETTK--MIIYLGDGRFHLESAMIANPLLKAYKYDPYEKKFTTEQYDHSAMQNLRLDAVQRAKKA 290
             :.:|  .|:|||||||||||.||.||.::|::||||.:|.|.|.|||..|:..|:.:::.|:|.
Worm   200 -DASKYDAIVYLGDGRFHLESIMIHNPEIEAFQYDPYSRKLTREFYDHDLMRKNRIGSIEIARKC 263

  Fly   291 RRIGIILGTLGRQGSSRVHRFLEKRLHAKGIETTTLLLSEIFPQKLALFADIDAFVQIACPRLSI 355
            ...|:|.|||||||:.:|...||.:|..||.:...:|||||||:|||:|.::|.:||:|||||||
Worm   264 TTFGLIQGTLGRQGNLKVVEELEAQLERKGKKFLRVLLSEIFPEKLAMFPEVDCWVQVACPRLSI 328

  Fly   356 DWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPRNNAYPMDFYASGSLGPWTPN 408
            |||:.|.:|||.|:||:|.|.::      |.|.:: :|||:|::.||||||.|
Worm   329 DWGTQFPKPLLYPFELAVALDNI------SVPSDH-WPMDYYSNDSLGPWTNN 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dph1	NP_001261722.1	Diphthamide_syn	83..380	CDD:280107	166/300 (55%)
dph-1	NP_497750.1	Diphthamide_syn	55..352	CDD:280107	166/305 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160387
Domainoid	1	1.000	342	1.000	Domainoid score	I571
eggNOG	1	0.900	-	-		E1_COG1736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1059
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1064
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62277
OrthoDB	1	1.010	-	-		D300951at33208
OrthoFinder	1	1.000	-	-		FOG0003904
OrthoInspector	1	1.000	-	-		oto19153
orthoMCL	1	0.900	-	-		OOG6_101267
Panther	1	1.100	-	-	LDO	PTHR10762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R336
SonicParanoid	1	1.000	-	-		X2688
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800