DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14135 and THAP12

DIOPT Version :9

Sequence 1:	NP_001261721.1	Gene:	CG14135 / 39316	FlyBaseID:	FBgn0036193	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_004696.2	Gene:	THAP12 / 5612	HGNCID:	9440	Length:	761	Species:	Homo sapiens

Alignment Length:	267	Identity:	57/267 - (21%)
Similarity:	96/267 - (35%)	Gaps:	81/267 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CAVKNCGNNNRIANRTKWRYFHFPKEKPNLQRWIDFCQRDNINPTTACICNEHF--APNDFERNM 65
            ||..||   .|.:.::...:|.||::....|:|::.|:|.::...|....|:|:  ....||.:|
Human     5 CAAPNC---TRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSM 66

  Fly    66 QYELGFSRKNP--TKLKPGSFPSV-------NGP----QKLAKELRGSIKRGSKSVPLAGSTKMS 117
                 ..|.:|  |.|:..:.|::       |.|    :|..|||.....|..|...:..:::.
Human    67 -----ICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQ- 125

  Fly   118 NIGFDPHHAGTQSSEGHETIEIQLCGFNTDIEGFEEAEDDDCPSGPRLVEVEILDPLNPQSNAKD 182
                :..|..|.:|......|             ||.|..|          |.:.||.
Human   126 ----EQKHKETNNSNAQNPSE-------------EEGEGQD----------EDILPLT------- 156

  Fly   183 HVEIIDSEGDSYVKHL-ELEICSLKREV-------------FFLKDEYQKIKAEMRNLKDTIKRS 233
               :.:.|...|:|.| |:.|...|:.:             .|..|.:|.:      |:..|...
Human   157 ---LEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFTPDNFQAL------LECRINSG 212

  Fly   234 EEELAEK 240
            ||.|.::
Human   213 EEVLRKR 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14135	NP_001261721.1	THAP	2..88	CDD:283206	23/95 (24%)
CG14135	NP_001261721.1	GrpE	198..>239	CDD:295646	12/54 (22%)
THAP12	NP_004696.2	THAP	6..86	CDD:398893	22/87 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..149		7/50 (14%)
		DUF4371	<157..330	CDD:405048	15/69 (22%)
		Dimer_Tnp_hAT	<672..729	CDD:399013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910