DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14135 and CG6689

DIOPT Version :9

Sequence 1:	NP_001261721.1	Gene:	CG14135 / 39316	FlyBaseID:	FBgn0036193	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	77/310 - (24%)
Similarity:	118/310 - (38%)	Gaps:	103/310 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRCAVKNCGN------NNRIANRTKWRYFHFPKEKPNLQRWIDFC--QRDNINPTTACICNEHFA 57
            |||||.||.|      ....|.:.:..:|.|||.....:.|:.||  ..:::.....|||.|||.
  Fly     1 MRCAVPNCRNFSDCRSKRNAAQQQRLGFFRFPKCPDTFKAWLAFCGYTEESLKLKNPCICIEHFK 65

  Fly    58 PNDFERNMQYELGFSRKNPTKLKPGSFPSVNGPQK----LAKELRGSIKRGSKSV---------- 108
            ..|.|.::::|:|.::|.  .|:||:.|.||..|:    .|::.|...:|..:.|
  Fly    66 DEDIEGSLKFEMGLAKKR--TLRPGAVPCVNKSQESGSDRARKERSQRRRNQELVAELLAEEEAK 128

  Fly   109 ---PLAGSTKMSNI--------GFDPHHAGTQSSEGHETI-EIQLC-----GFNTDIEGFEEAED 156
               |.|.|.:..::        ..||       ..|.|.: |:|.|     .|..|.    .|:|
  Fly   129 LIHPEATSFEQDSVYLSETVTMELDP-------LSGEEKLEELQKCRTCYNDFTADF----RAKD 182

  Fly   157 DDCPSGPRLVEVEILDPLNPQSNAKDHVEIIDSEGDSYVKH------LELEIC--SLKREVFF-- 211
                         :.||.|  |....|:|:|..   .::.|      |....|  :|.:.:.|
  Fly   183 -------------LFDPAN--SVLLFHIEVISG---VWISHKPDEPRLMCPACKSALDQAIDFRE 229

  Fly   212 ------LK--------DEYQKIKAEMRN--------LKDTIKRSEEELAE 239
                  ||        ||.| |:||..|        :.||...:.||:.:
  Fly   230 MCISTELKLSQAKPSTDEVQ-IEAENENPISSDHDLISDTENTNVEEIED 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14135	NP_001261721.1	THAP	2..88	CDD:283206	30/93 (32%)
CG14135	NP_001261721.1	GrpE	198..>239	CDD:295646	17/66 (26%)
CG6689	NP_650051.1	THAP	2..96	CDD:283206	32/95 (34%)
		zf-AD	167..240	CDD:214871	19/94 (20%)
		zf-C2H2	385..407	CDD:278523
		C2H2 Zn finger	387..407	CDD:275368
		zf-H2C2_2	399..422	CDD:290200
		C2H2 Zn finger	415..436	CDD:275368
		C2H2 Zn finger	444..460	CDD:275368
		C2H2 Zn finger	492..512	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
		zf-met	574..597	CDD:289631
		C2H2 Zn finger	575..591	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11471
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910