DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14135 and Thap4

DIOPT Version :9

Sequence 1:	NP_001261721.1	Gene:	CG14135 / 39316	FlyBaseID:	FBgn0036193	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001005564.1	Gene:	Thap4 / 363291	RGDID:	1359473	Length:	569	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	78/398 - (19%)
Similarity:	122/398 - (30%)	Gaps:	180/398 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CAVKNCGNNNRIANRTKWRYFHFP-KEKPNLQRWIDFCQRDNINPTT-ACICNEHFAPNDFERNM 65
            ||..||.|......:....:..|| |:...|.:|:...||||..||. :.:|:|||..:.|.:.:
  Rat     5 CAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRL 69

  Fly    66 --QYELGFSRKNPTKLKPGSFPSV------------NGP--QKLAKELRG--------------- 99
              |:.|         |||.:.||:            :||  :|....:||
  Rat    70 EDQHRL---------LKPTAVPSIFHLSEKKRGAGGHGPARRKTTGAMRGHTSAATGKGTIGSSL 125

  Fly   100 ---------------------------------------SIKR--GSKSVPLA------------ 111
                                                   |::|  |.::.|||
  Rat   126 SSSDNLMAKPESRKLKRASPQDDTAPKATPGAVSQEPGQSLERTPGDQAAPLARGQEEAQVSATE 190

  Fly   112 -----------------------------GSTKMSNIG------FDPHHAGTQSSEGHETIEIQL 141
                                         ||.....||      |...|...:.|...|.::.:
  Rat   191 ADHQKASSSAADAGGADKSGISMDDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPMDRK- 254

  Fly   142 CGFNTDIE----GFEEAED-------------DDCPSGP----------RLVEVEILDPLNPQS- 178
             ....|||    |...|:.             ...||.|          ..|:.|..| .||.|
  Rat   255 -RLKRDIEPRCSGNSVAQSPPSSSLTATPQKASQSPSAPPTDVTPKPAAEAVQSEHSD-ANPMSI 317

  Fly   179 -----NAKDHVEIIDSEGDSY---VKHLELEICSLKREVFFLKDEYQKIKAEMRNLKDTIKRSEE 235
                 :|....::|||. .||   .:..:.::|.|:.:|       :|...|:::|:..:.||:.
  Rat   318 NEVILSASGACKLIDSL-HSYCFSARQNKSQVCCLREQV-------EKKNGELKSLRQRVSRSDS 374

  Fly   236 E---LAEK 240
            :   |.||
  Rat   375 QVRKLREK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14135	NP_001261721.1	THAP	2..88	CDD:283206	28/100 (28%)
CG14135	NP_001261721.1	GrpE	198..>239	CDD:295646	9/43 (21%)
Thap4	NP_001005564.1	THAP	4..86	CDD:283206	28/89 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..219		12/135 (9%)
		HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:Q8WTV1	230..233		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..312		15/79 (19%)
		Nitrobindin. /evidence=ECO:0000250\|UniProtKB:Q8WY91	407..569
		DUF1794	414..566	CDD:285921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910