DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14135 and THAP5

DIOPT Version :9

Sequence 1:	NP_001261721.1	Gene:	CG14135 / 39316	FlyBaseID:	FBgn0036193	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001123947.1	Gene:	THAP5 / 168451	HGNCID:	23188	Length:	395	Species:	Homo sapiens

Alignment Length:	388	Identity:	65/388 - (16%)
Similarity:	131/388 - (33%)	Gaps:	158/388 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CAVKNC----GNNNRIANRTKWRYFHFP-KEKPNLQRWIDFCQRDNINPTT-ACICNEHFAPNDF 61
            ||...|    |.||:   ..|..::.|| .:|..|::|:...:||:..|:. ..:|::||.|:..
Human     5 CAAICCKNRRGRNNK---DRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSL 66

  Fly    62 ERNMQYELGFSR----------------KNPTKLK------------------------------ 80
            :  :::.:.:.:                |:|:|.|
Human    67 D--IRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKSQKKNLEDEKEVCPKAKSEESFVLNETKKN 129

  Fly    81 ------PGSFPSVNGPQKLAK---ELRGSIKRGSKSVPLA-------GSTKMSNIGFDPHHAG-- 127
                  |...|.:.....|.|   ...|||:....::.|.       .||..:::..|....|
Human   130 IVNTDVPHQHPELLHSSSLVKPPAPKTGSIQNNMLTLNLVKQHTGKPESTLETSVNQDTGRGGFH 194

  Fly   128 --------------TQSSEG-HETIEIQLC-----------GFNTDIEGFEEAEDDDCPSGPRLV 166
                          |.:||. |:::|.|..           .|.::....:.|:::     |.|.
Human   195 TCFENLNSTTITLTTSNSESIHQSLETQEVLEVTTSHLANPNFTSNSMEIKSAQEN-----PFLF 254

  Fly   167 EV--EILDPLN-----------PQSNAKDHV------------------------------EIID 188
            ..  :.::.||           |..|:|..|                              |::.
Human   255 STINQTVEELNTNKESVIAIFVPAENSKPSVNSFISAQKETTEMEDTDIEDSLYKDVDYGTEVLQ 319

  Fly   189 SEGDSYVK------HLELEICSLKREVFFLKDEYQKIKAEMRNLKDTIKRSEEE--LAEKQLQ 243
            .| .||.:      ||..::..|..::..|:.:.|:....:::|:..|::.::|  |:|:.::
Human   320 IE-HSYCRQDINKEHLWQKVSKLHSKITLLELKEQQTLGRLKSLEALIRQLKQENWLSEENVK 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14135	NP_001261721.1	THAP	2..88	CDD:283206	25/142 (18%)
CG14135	NP_001261721.1	GrpE	198..>239	CDD:295646	8/42 (19%)
THAP5	NP_001123947.1	THAP	4..85	CDD:214951	19/84 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..112		4/26 (15%)
		RILP-like	<315..>373	CDD:304877	11/58 (19%)
		HCFC1-binding motif (HBM). /evidence=ECO:0000250	321..324		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910