DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sugb and Mfsd6

DIOPT Version :9

Sequence 1:	NP_648493.3	Gene:	Sugb / 39314	FlyBaseID:	FBgn0036191	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_598590.2	Gene:	Mfsd6 / 98682	MGIID:	1922925	Length:	794	Species:	Mus musculus

Alignment Length:	681	Identity:	159/681 - (23%)
Similarity:	265/681 - (38%)	Gaps:	155/681 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IDKELLPMKAHYFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRY 69
            ::.:||..|..||.|.:....:.|.:|....|||.||:..|.:..|...|...:.|.:|.:|||:
Mouse    65 VNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF 129

  Fly    70 HRHRPLFLGGQVLTGIAFFL-IMFV-PGMEKPLPKVEFHCH-----QGVSDIP------RFCSEY 121
            .:.:.:.| ..:|..:.|.| |.|| |...:.|||:....|     ..|:.:|      .|.|..
Mouse   130 RKGKIVLL-FSLLCWVLFNLGIGFVKPATLRCLPKIPPTAHPTNVSHPVTVLPMNSSTVAFFSTP 193

  Fly   122 GECVERNLERYYGNRTLECELNCEAQPFMWDI-VCEDWLKNNTENCAANRTNTQMEFGASITMQK 185
            .:.:::.          :.:|: |.:|.:.|| :....|...:|  ...|..|:
Mouse   194 PKLLQKR----------DVQLS-ETEPNISDIDLVSTALTLTSE--PTRRPQTE----------- 234

  Fly   186 IENDGSCMFFMIPHDQGQIAGQNVTLYCPKEKEYFKSNCTMDCREDYLKEQLAESAVINTSSAVT 250
                      .|.|....:.....|:..|.     ..|.|   ||..:       ||:.|:.::.
Mouse   235 ----------AITHPVTGLILNTSTVTLPP-----TGNVT---RETTI-------AVVTTTKSLP 274

  Fly   251 MPQFWL----------FFGLLIFSWIG---MAVVVSIGDAICFGILGDRHHLYGKQRLCGSLGWG 302
            ..|..|          |..:|:...||   .|..|:|.|.:....||.....||.||:.||||||
Mouse   275 SDQVTLVYDQQEVEAIFLIILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWG 339

  Fly   303 VFALLAGLLVDHMSLGEV----------NKNYTAVFWMALLIMGFDVFASSKLR----------- 346
            :..|..|:.:|:..:..:          .:||..||.:..::|...:..:::.|
Mouse   340 LAMLSVGIGIDYTHIDVLIDGKGCKPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFNNSDG 404

  Fly   347 --------------------HTP---THLSSNILKDVGQMFLSVR--CVIFFLWCVAIGLGTALI 386
                                .||   ||..:....|:.::..||:  .|:|..|.:..|.|  .:
Mouse   405 KGKEVEIPQVERDNSTESSEETPTAATHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYG--FV 467

  Fly   387 WNFLFIYLEELDKAFEGCDSSIKTLEGLVMGIQCFGGELPFFFLSGWILKKIGHVNAMSVVLFGF 451
            :.||:.:||:|        :...||.| |..:.....||..:|.|..:::.|||:..:.:.|...
Mouse   468 FTFLYWHLEDL--------NGTTTLFG-VCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN 523

  Fly   452 GVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFEGVGVSM 516
            ..|:|..|.|:|.|.:||:|::.|||....:|...||.|...||....:.|.::..:..|:|...
Mouse   524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGC 588

  Fly   517 GSLIAGQLFESVTARTTFEIFGIGAFIVFVIHVCIQLYLQRNSNIDENGKGTVASASATASPSAP 581
            |::|.|.|.....|..||...|:...::.::...||.....:   :|..|..:|......|...|
Mouse   589 GAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVPD---EEEDKTMLAERIPVPSSPVP 650

  Fly   582 LET---------DI---------PKNTDHKD 594
            :.|         |:         ||.|.|::
Mouse   651 IATIDLVQQQTEDVMPRVEARLPPKKTKHQE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sugb	NP_648493.3	MFS	9..82	CDD:304372	22/72 (31%)
		MFS_1	16..>96	CDD:284993	26/81 (32%)
		MFS_1	<252..518	CDD:284993	81/324 (25%)
		MFS	<254..547	CDD:119392	88/351 (25%)
Mfsd6	NP_598590.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..47
		MFS_MFSD6	71..625	CDD:340893	145/614 (24%)
		PHA03381	666..>779	CDD:177618	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010