DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sugb and SCN10A

DIOPT Version :9

Sequence 1:	NP_648493.3	Gene:	Sugb / 39314	FlyBaseID:	FBgn0036191	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_005265428.1	Gene:	SCN10A / 6336	HGNCID:	10582	Length:	1959	Species:	Homo sapiens

Alignment Length:	467	Identity:	100/467 - (21%)
Similarity:	148/467 - (31%)	Gaps:	176/467 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GYIADRYHRHR-PLFLGGQVLTGIAFFLIMFVPGMEKPLPKVEF---------HC---HQ----- 109
            |.....:..|| .|.|||..             |.:.|||:...         |.   ||
Human   527 GVFPGDHESHRGSLLLGGGA-------------GQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTS 578

  Fly   110 ----GVSDIPRF---------CSEYGECVERNLERYYGNRTL--------------ECELNCE-- 145
                |..|:..|         .:||.:      |.:...|.:              |.|..|.
Human   579 ELAPGAVDVSAFDAGQKKTFLSAEYLD------EPFRAQRAMSVVSIITSVLEELEESEQKCPPC 637

  Fly   146 ----AQPFM-WDIVCEDWLKNNTENCAANRTNTQMEFG--------ASITMQKIENDGSCMFFMI 197
                :|.:: || .|..|:|..|           :.||        .:||:..:.|    ..||.
Human   638 LTSLSQKYLIWD-CCPMWVKLKT-----------ILFGLVTDPFAELTITLCIVVN----TIFMA 686

  Fly   198 PHDQG---------QIAGQNVTLYCPKEK----------EYFKSNCTM-DCREDYLKEQLAESAV 242
            ....|         ||.....|::...|.          .||:....: ||  ..:...|.|..|
Human   687 MEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDC--IIVTVSLLELGV 749

  Fly   243 INTSSAVTMPQFWLFFGLLIF----SWIGMAVVVS-IGDAICFGILGDRHHLYGKQRLCGSLGWG 302
            ....|...:..|.|   |.:|    ||..:..::. ||:::  |.||:         |...|...
Human   750 AKKGSLSVLRSFRL---LRVFKLAKSWPTLNTLIKIIGNSV--GALGN---------LTIILAII 800

  Fly   303 VFALLAGLLVDHMSLGE----VNKNYTAV-----------FWMALLIMGFDVFASSKLRHTPTHL 352
            ||..   .||....|||    ..||.:|.           |:.:.||: |.:.....:.:....:
Human   801 VFVF---ALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIV-FRILCGEWIENMWACM 861

  Fly   353 SSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELDKAFEG-------CDSSIKT 410
                  :|||..:   |:|.||  ..:.||..::.| |||.|  |..:|..       .|..:..
Human   862 ------EVGQKSI---CLILFL--TVMVLGNLVVLN-LFIAL--LLNSFSADNLTAPEDDGEVNN 912

  Fly   411 LEGLVMGIQCFG 422
            |:..:..||.||
Human   913 LQVALARIQVFG 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sugb	NP_648493.3	MFS	9..82	CDD:304372	7/19 (37%)
		MFS_1	16..>96	CDD:284993	7/33 (21%)
		MFS_1	<252..518	CDD:284993	49/198 (25%)
		MFS	<254..547	CDD:119392	49/196 (25%)
SCN10A	XP_005265428.1	Ion_trans	150..410	CDD:278921
		Na_trans_cytopl	466..>537	CDD:288761	1/9 (11%)
		Ion_trans	685..897	CDD:278921	56/245 (23%)
		Na_trans_assoc	907..1150	CDD:284034	6/18 (33%)
		Ion_trans	1172..1430	CDD:278921
		Na_channel_gate	1422..1474	CDD:240441
		Ion_trans	1496..1735	CDD:278921
		GPHH	1745..1802	CDD:293510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.78878	Normalized mean entropy	S3904
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950