DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sugb and MFSD6

DIOPT Version :9

Sequence 1:	NP_648493.3	Gene:	Sugb / 39314	FlyBaseID:	FBgn0036191	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001362915.1	Gene:	MFSD6 / 54842	HGNCID:	24711	Length:	791	Species:	Homo sapiens

Alignment Length:	687	Identity:	160/687 - (23%)
Similarity:	264/687 - (38%)	Gaps:	169/687 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IDKELLPMKAHYFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRY 69
            |:.:||..|..||.|.:....:.|.:|....|||.||:..|.:..|...|...:.|.:|.:|||:
Human    64 INNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF 128

  Fly    70 HRHRPLFLGGQVLTGIAFFL-IMFV-PGMEKPLPKVEFHCH-----QGVSDIPRFCS-------- 119
            .:.:.:.| ..:|..:.|.| |.|| |...:.:||:....|     ..::.:|...|
Human   129 KKGKIVLL-FSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILPTNSSFTSFLTIS 192

  Fly   120 -EYGECVERNLERYYGNRTLECELNCE---AQPFMWDIVCEDWLKNNTENCAANRTNTQMEFGAS 180
             :..|  :|||        ||..||..   ..|...::..|..|:..|    ...||..|:
Human   193 PKMRE--KRNL--------LETRLNVSDTVTLPTAPNMNSEPTLQPQT----GEITNRMMD---- 239

  Fly   181 ITMQKIENDGSCMFFMIPHDQGQIAGQNVTLYCPKEKEYFKSNCTMDCREDYLKEQLAESAVINT 245
            :|:    |..:.    .|...|.:..:..|:                              ::.|
Human   240 LTL----NSSTA----TPVSPGSVTKETTTV------------------------------IVTT 266

  Fly   246 SSAVTMPQFWL----------FFGLLIFSWIG---MAVVVSIGDAICFGILGDRHHLYGKQRLCG 297
            :.::...|..|          |..:|:...||   .|..|:|.|.:....||.....||.||:.|
Human   267 TKSLPSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWG 331

  Fly   298 SLGWGVFALLAGLLVDHMSLGEV-----------NKNYTAVFWMALLIMGFDVFASSKLR----- 346
            |||||:..|..|:.:|:..: ||           .:||..||.:..::|...:..:::.|
Human   332 SLGWGLAMLSVGIGIDYTHI-EVLIDGKGCKPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNH 395

  Fly   347 --------------------------HTPT---HLSSNILKDVGQMFLSVR--CVIFFLWCVAIG 380
                                      .|||   |..:....|:.::..||:  .|:|..|.:..|
Human   396 FKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFG 460

  Fly   381 LGTALIWNFLFIYLEELDKAFEGCDSSIKTLEGLVMGIQCFGGELPFFFLSGWILKKIGHVNAMS 445
            .|  .::.||:.:||:|        :...||.| |..:.....||..:|.|..:::.|||:..:.
Human   461 YG--FVFTFLYWHLEDL--------NGTTTLFG-VCSVLSHVSELTAYFFSHKLIELIGHIRVLY 514

  Fly   446 VVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFE 510
            :.|.....|:|..|.|:|.|.:||:|::.|||....:|...||.|...||....:.|.::..:..
Human   515 IGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHL 579

  Fly   511 GVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHVCIQLYLQRNSNIDENGKGTVASASAT 575
            |:|...|::|.|.|.....|..||...|:...::.::...||.....:   :|..|..:|.....
Human   580 GLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVPD---EEEDKTMLAERIPV 641

  Fly   576 ASPSAPLET---------DI---------PKNTDHKD 594
            .|...|:.|         |:         ||.|.|::
Human   642 PSSPVPIATIDLVQQQTEDVMPRIEPRLPPKKTKHQE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sugb	NP_648493.3	MFS	9..82	CDD:304372	22/72 (31%)
		MFS_1	16..>96	CDD:284993	26/81 (32%)
		MFS_1	<252..518	CDD:284993	83/325 (26%)
		MFS	<254..547	CDD:119392	90/352 (26%)
MFSD6	NP_001362915.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..47
		MFS_MFSD6	70..622	CDD:340893	145/620 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..427		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..687		4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010