DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sugb and mfsd6a

DIOPT Version :9

Sequence 1:	NP_648493.3	Gene:	Sugb / 39314	FlyBaseID:	FBgn0036191	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001076525.1	Gene:	mfsd6a / 100034426	ZFINID:	ZDB-GENE-050208-335	Length:	793	Species:	Danio rerio

Alignment Length:	673	Identity:	141/673 - (20%)
Similarity:	249/673 - (36%)	Gaps:	157/673 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IDKELLPMKAHYFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRY 69
            :::.||..|..|..|.|....:.|.:.....|||.:|...|.:..|...|...:.|.:|.:||||
Zfish    66 VNRHLLVSKVFYLFFYAAYGSLHPLLALYYKQLGMNPTQSGLLVGIRYFIEFCSAPFWGIVADRY 130

  Fly    70 HRHRPLFLGGQVLTGIAFFLIMFVPGMEKPLPKVEFHCHQGVSDIPRFCSEYGECVERNL----- 129
            .:      |..||.......|:|..|:             |:...|...     |.|..:
Zfish   131 RK------GKAVLLFSMLCWILFNAGI-------------GIVKPPIMA-----CKEETIPTTTK 171

  Fly   130 ----------ERYYGNRTLECELNCEAQPFMWDIVCE-DWLKNNTENCAANRTNTQMEFGAS--- 180
                      |.::.|.:...::....     |::.: .|             .|.:..|.|
Zfish   172 VPTVHPTPSNETFFPNTSSTSQMRRRR-----DLIGQYPW-------------RTILSSGQSSGY 218

  Fly   181 ITMQKIENDGSCMFFMIPHDQGQI--AGQNVTLYCPKEKEYFKSNCTMDCREDYLKEQLAESAVI 243
            |:..:|:.|.:..|...|.:....  ..|..|...||......::              ..|:..
Zfish   219 ISEHRIKRDSNLSFTPAPEELANTTQTNQTSTTTQPKPSTSISTS--------------TPSSTN 269

  Fly   244 NTSSAVTM----------PQF------WLFFGLLIFSWIG---MAVVVSIGDAICFGILGDRHHL 289
            .|||:.|.          |::      .:|..:|:...||   .|..::|.|.:....||.....
Zfish   270 TTSSSTTKSTTTNPNLPPPEYNMDQVNAIFLLILLVIIIGEFFSAPAITIVDTVTLHYLGPHRDR 334

  Fly   290 YGKQRLCGSLGWGVFALLAGLLVDHMS----LGEVN------KNYTAVFWMALLIMGFDVFASSK 344
            ||.||:.||||||:..|..|:.:||.|    :|.:.      |||...|.:..::|...:..:::
Zfish   335 YGLQRMWGSLGWGLAMLCIGIWIDHTSTNLIIGNMECIMKNYKNYHIAFIVFGVLMVIALIVATQ 399

  Fly   345 LRHTPTHLSSNILKDVGQM------------------------------FLSVRC------VIFF 373
            .:....|..:|..::||..                              .:.:.|      |:|.
Zfish   400 FKFDVQHHDTNEGQEVGNQQENVQPRGSPGTRSTDTPTIVQAEEFHFWDLMRLLCGVQYSTVLFV 464

  Fly   374 LWCVAIGLGTALIWNFLFIYLEELDKAFEGCDSSIKTLEGLVMGIQCFGGELPFFFLSGWILKKI 438
            .|.:..|.|  .::.||:.:|::|        :...||.| :..:.....||..:|.|...::.:
Zfish   465 AWFMGFGYG--FVFTFLYWHLQDL--------TGTTTLFG-ICSVLSHVSELAAYFTSHKFIELV 518

  Fly   439 GHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQS 503
            ||:..:.:.|.....|::..|.|:|.|.:||:|::.|:|....:|...||.|...||....:.|.
Zfish   519 GHIRVLYIGLACNTARYLYISYLENAWTVLPMEVLQGITHASVWAACISYLSAAVPPPLRTSAQG 583

  Fly   504 LVGAIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHVCIQLYLQRNSNIDENGKGT 568
            ::..:..|:|...|:::.|..........||...|:.:.::.:|...|.....:|...::  |..
Zfish   584 ILQGLHLGLGRGCGAMVGGIFVNYFGVAETFRGIGMASLVILLIFSLIMYITGQNEKKED--KML 646

  Fly   569 VASASATASPSAPLET-DIPKNT 590
            ..:....:|| .|:.| |:.:||
Zfish   647 AENIPIPSSP-VPIATIDLVQNT 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sugb	NP_648493.3	MFS	9..82	CDD:304372	21/72 (29%)
		MFS_1	16..>96	CDD:284993	22/79 (28%)
		MFS_1	<252..518	CDD:284993	74/320 (23%)
		MFS	<254..547	CDD:119392	78/347 (22%)
mfsd6a	NP_001076525.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..53
		MFS_1_like	69..144	CDD:289593	23/80 (29%)
		MFS_1	77..>154	CDD:284993	24/95 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..288		9/62 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..434		2/21 (10%)
		MFS_1	461..>659	CDD:284993	49/211 (23%)
		MFS	461..>632	CDD:119392	44/181 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010