DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIEalpha and gtf2e1.2

DIOPT Version :9

Sequence 1:	NP_524026.1	Gene:	TfIIEalpha / 39313	FlyBaseID:	FBgn0015828	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001072556.1	Gene:	gtf2e1.2 / 780011	XenbaseID:	XB-GENE-6001963	Length:	421	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	172/422 - (40%)
Similarity:	262/422 - (62%)	Gaps:	20/422 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VTEVPSSLKQLARLVVRGFYSLEDALIIDMLVRNPCMKEDDIGELLRFEKKQLRARITTLRTDKF 85
            :||||::||:||:.:|||||.||.:|.:|:|:|.||:||||||.||:|||||||..:.||:.|||
Frog     7 MTEVPAALKRLAKYMVRGFYGLEYSLTLDVLIRYPCVKEDDIGLLLKFEKKQLRTILNTLKADKF 71

  Fly    86 IQIRLKMETGPDGKAQKVNYYFINYKTFVNVVKYKLDLMRKRMETEERDATSRASFKCSSCSKTF 150
            |:.|:::||||:||:.:.|||:||||..|:|||||||.:|:::|::|||:|:||||||..|..|:
Frog    72 IKCRMRVETGPNGKSTRHNYYYINYKVLVDVVKYKLDHVRRKIESDERDSTTRASFKCPGCLSTY 136

  Fly   151 TDLEADQLFDMATLEFRCTFCGSSVEEDSAAMPKKDSRLMLAHFNEQLQPLYDLLREVEGIKLAP 215
            :|||.:||||..|..||||:|...|||||:::||:|:|.:||.||||::|::.||:|.|.|.|..
Frog   137 SDLEVNQLFDPFTELFRCTYCNVEVEEDSSSLPKRDARTLLARFNEQIEPIFVLLQETEDIILPC 201

  Fly   216 EVLEPEPVDIDTIRGL--NKPNATRPDGMAWSGE-ATRNQGFAVEETRVDVTIGGDDTSDAVIER 277
            |:|||:|.:|..:.|.  .:.::...|.....|: |.::....:....|.:.:...|......||
Frog   202 ELLEPQPTEIPELCGSFDQQSSSLALDLQGQQGKWANKSSVGNMYVQNVTINVRESDFKKKGKER 266

  Fly   278 --KSRPIWMTESTVITDTDAADGA-----ADAVQTASGSGHRNRKENEDIMSVLLQHEKQPGQKE 335
              |.:|:||.:|||.........|     |..::..:.:...:..:||.|.::|:...|.
Frog   267 KVKEQPVWMKDSTVHGSPPEESSASFKTEAPLIEDENANLKEDNPDNEVIRTLLIHEMKS----- 326

  Fly   336 PHMKGMRVGSSNANSSDSSDDEKDIENSKIPDVDFDNYINSDSAEEDDDV-PTVLVAGRPHPLDQ 399
              |.|..|.|...:.|.|...|.|.|.........:::.|::..||.:.| |.|:|:|:||...:
Frog   327 --MSGPAVNSFPKSDSGSDTSESDEEKKSTKPAPGESHSNAEQEEESETVDPVVMVSGQPHVYSE 389

  Fly   400 LDDN--LIAQMTPQEKENYIHVYQQHYSHIFE 429
            :..|  |::.||.:|:|.||.|.|:.:..:||
Frog   390 VSQNPSLVSFMTEEEREAYITVGQKMFQSVFE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIEalpha	NP_524026.1	HTH	30..137	CDD:304362	63/106 (59%)
		TFIIE	43..188	CDD:128804	85/144 (59%)
		TFIIE-A_C	357..429	CDD:288386	23/74 (31%)
gtf2e1.2	NP_001072556.1	TFIIE	29..175	CDD:128804	85/145 (59%)
gtf2e1.2	NP_001072556.1	TFIIE-A_C	340..421	CDD:402908	25/80 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4476
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343016at2759
OrthoFinder	1	1.000	-	-		FOG0003249
OrthoInspector	1	1.000	-	-		otm48026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1464
SonicParanoid	1	1.000	-	-		X4875
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090