DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIEalpha and gtf2e1

DIOPT Version :9

Sequence 1:	NP_524026.1	Gene:	TfIIEalpha / 39313	FlyBaseID:	FBgn0015828	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001005005.1	Gene:	gtf2e1 / 448491	XenbaseID:	XB-GENE-959290	Length:	435	Species:	Xenopus tropicalis

Alignment Length:	442	Identity:	204/442 - (46%)
Similarity:	280/442 - (63%)	Gaps:	36/442 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TEVRYVTEVPSSLKQLARLVVRGFYSLEDALIIDMLVRNPCMKEDDIGELLRFEKKQLRARITTL 80
            |:....||||:.||:||:.||||||.||.||.:|:|:||||:||||:.|||:|::|||||.:.||
Frog     2 TDPDVATEVPAVLKRLAKYVVRGFYGLEHALALDILIRNPCVKEDDMMELLKFDRKQLRAVLNTL 66

  Fly    81 RTDKFIQIRLKMETGPDGKAQKVNYYFINYKTFVNVVKYKLDLMRKRMETEERDATSRASFKCSS 145
            :.||||:.|:::||..|||..:.|||||||:..|||||||||.||:|:||:|||:|:||||||.:
Frog    67 KGDKFIKCRMRVETATDGKTTRHNYYFINYRLLVNVVKYKLDHMRRRIETDERDSTNRASFKCPN 131

  Fly   146 CSKTFTDLEADQLFDMATLEFRCTFCGSSVEEDSAAMPKKDSRLMLAHFNEQLQPLYDLLREVEG 210
            |..|||||||:||||..|..||||||.:.||||.:||||||:|.::|.||||::|:|.||||.|.
Frog   132 CCSTFTDLEANQLFDPMTGMFRCTFCQTEVEEDESAMPKKDARTLVARFNEQIEPIYALLRETED 196

  Fly   211 IKLAPEVLEPEPVDIDTIRGLNKPNATRPDGMAWSG---EATRNQGFAVEETRV-DVTIGGDDTS 271
            |.||.|:|||||.:|.::| .||..|......| ||   ||..::|.:.|:... ||.|..::..
Frog   197 INLAYEILEPEPTEIPSLR-QNKERAAAAAAAA-SGPHREAWASKGPSYEDLYTQDVVISMEEQE 259

  Fly   272 DAVIER-------KSRPIWMTESTVITDTDAADGAADAVQTASGSG-----HRNR---KENEDIM 321
            |  ::|       |.||||:.||||   ..|...:.|......|:|     ..||   .|||::|
Frog   260 D--LQRAAEGKSVKERPIWLRESTV---QGAYSESGDLKDGGLGTGPFQEPEENRPMGDENEEVM 319

  Fly   322 SVLLQHEKQPGQ---KEPHMKGMRVGSSNANSSDSSDDEKDIENSKIPDVDFDN-YINSDSAEED 382
            ..||.|||:...   ..|......:|.|::: ||:|:.::|....:.|.....: |...|..:|.
Frog   320 QALLIHEKKSAAAVGASPAPASNALGGSDSD-SDTSESDQDSPAPRQPVGTLSHAYDEDDEDDEF 383

  Fly   383 DDVP---TVLVAGRPHPLDQLDD--NLIAQMTPQEKENYIHVYQQHYSHIFE 429
            :||.   ||.|.|||:|..::..  .|:.|||||||:.||.:.|:.:..:::
Frog   384 EDVASELTVTVGGRPYPYSEVSQRPELVPQMTPQEKKVYIEMGQKMFMDLYD 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIEalpha	NP_524026.1	HTH	30..137	CDD:304362	67/106 (63%)
		TFIIE	43..188	CDD:128804	94/144 (65%)
		TFIIE-A_C	357..429	CDD:288386	25/77 (32%)
gtf2e1	NP_001005005.1	TFIIE	29..175	CDD:128804	94/145 (65%)
gtf2e1	NP_001005005.1	TFIIE-A_C	<387..435	CDD:402908	18/47 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4476
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38062
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2299
OMA	1	1.010	-	-		QHG52052
OrthoDB	1	1.010	-	-		D1343016at2759
OrthoFinder	1	1.000	-	-		FOG0003249
OrthoInspector	1	1.000	-	-		otm48026
Panther	1	1.100	-	-	LDO	PTHR13097
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4875
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080