DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIEalpha and GTF2E1

DIOPT Version :9

Sequence 1:	NP_524026.1	Gene:	TfIIEalpha / 39313	FlyBaseID:	FBgn0015828	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_005504.2	Gene:	GTF2E1 / 2960	HGNCID:	4650	Length:	439	Species:	Homo sapiens

Alignment Length:	439	Identity:	201/439 - (45%)
Similarity:	272/439 - (61%)	Gaps:	36/439 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VTEVPSSLKQLARLVVRGFYSLEDALIIDMLVRNPCMKEDDIGELLRFEKKQLRARITTLRTDKF 85
            :||||::||:||:.|:||||.:|.||.:|:|:||.|:||:|:.|||:|::||||:.:..|:.|||
Human     7 LTEVPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQLRSVLNNLKGDKF 71

  Fly    86 IQIRLKMETGPDGKAQKVNYYFINYKTFVNVVKYKLDLMRKRMETEERDATSRASFKCSSCSKTF 150
            |:.|:::||..|||..:.|||||||:|.|||||||||.||:|:||:|||:|:||||||..||.||
Human    72 IKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERDSTNRASFKCPVCSSTF 136

  Fly   151 TDLEADQLFDMATLEFRCTFCGSSVEEDSAAMPKKDSRLMLAHFNEQLQPLYDLLREVEGIKLAP 215
            |||||:||||..|..||||||.:.||||.:||||||:|.:||.||||::|:|.||||.|.:.||.
Human   137 TDLEANQLFDPMTGTFRCTFCHTEVEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDVNLAY 201

  Fly   216 EVLEPEPVDIDTIRGLNKPNATRPDGMAWSG----EATRNQGFAVEETRV-DVTIGGDDTSD--- 272
            |:|||||.:|..::......||.....:.:|    ||...:|.:.|:... :|.|..||..|
Human   202 EILEPEPTEIPALKQSKDHAATTAGAASLAGGHHREAWATKGPSYEDLYTQNVVINMDDQEDLHR 266

  Fly   273 AVIERKS---RPIWMTESTV---ITDTDAADGA--ADAVQTASGSGHRNRKENEDIMSVLLQHEK 329
            |.:|.||   ||||:.||||   ....|..:|.  .||.|... .||....:||::|..||.|||
Human   267 ASLEGKSAKERPIWLRESTVQGAYGSEDMKEGGIDMDAFQERE-EGHAGPDDNEEVMRALLIHEK 330

  Fly   330 QPGQKEPHMKGMRVGSSNANSSDSSDDEKDIENSKIP------------DVDFDNYINSDSAEED 382
            :.........|.....:.||.|||..:..:.::...|            |.:.|     |..||.
Human   331 KTSSAMAGSVGAAAPVTAANGSDSESETSESDDDSPPRPAAVAVHKREEDEEED-----DEFEEV 390

  Fly   383 DDVPTVLVAGRPHPLDQLDD--NLIAQMTPQEKENYIHVYQQHYSHIFE 429
            .|.|.|:|||||....::..  .|:|||||:|||.||.:.|:.:..:||
Human   391 ADDPIVMVAGRPFSYSEVSQRPELVAQMTPEEKEAYIAMGQRMFEDLFE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIEalpha	NP_524026.1	HTH	30..137	CDD:304362	62/106 (58%)
		TFIIE	43..188	CDD:128804	92/144 (64%)
		TFIIE-A_C	357..429	CDD:288386	26/85 (31%)
GTF2E1	NP_005504.2	TFIIE	28..175	CDD:128804	92/146 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..393		12/65 (18%)
		TFIIE-A_C	<394..439	CDD:402908	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149571
Domainoid	1	1.000	140	1.000	Domainoid score	I4776
eggNOG	1	0.900	-	-		E1_COG1675
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38062
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2295
Isobase	1	0.950	-	0	Normalized mean entropy	S2252
OMA	1	1.010	-	-		QHG52052
OrthoDB	1	1.010	-	-		D1343016at2759
OrthoFinder	1	1.000	-	-		FOG0003249
OrthoInspector	1	1.000	-	-		oto89200
orthoMCL	1	0.900	-	-		OOG6_104238
Panther	1	1.100	-	-	LDO	PTHR13097
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1464
SonicParanoid	1	1.000	-	-		X4875
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750