DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and RAD7

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_012586.1	Gene:	RAD7 / 853512	SGDID:	S000003813	Length:	565	Species:	Saccharomyces cerevisiae

Alignment Length:	322	Identity:	73/322 - (22%)
Similarity:	118/322 - (36%)	Gaps:	88/322 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 LLDHLQSLF------ELELAGCNEVTEAG--LWACLTPRIVSLSLADCINIADEAVGAVAQLLPS 456
            |.||...||      .|..:.|::::..|  ..|..:|.:..|||..|..:..|::..:|:.||:
Yeast   223 LNDHTLQLFLKTDLKRLTFSDCSKISFDGYKTLAIFSPHLTELSLQMCGQLNHESLLYIAEKLPN 287

  Fly   457 LYEFS----------------------LQAYHV------TDAALG-------------------- 473
            |...:                      |:.:|:      ||.:|.
Yeast   288 LKSLNLDGPFLINEDTWEKFFVIMKGRLEEFHISNTHRFTDKSLSNLLINCGSTLVSLGLSRLDS 352

  Fly   474 ---------YFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPH-LTVLSLSGCSKLTD----DG 524
                     |....:.|||.|....:..::.:..|:|::..:.. |..|.|:||..|||    :|
Yeast   353 ISNYALLPQYLVNDEFHSLCIEYPFNEEDVNDEIIINLLGQIGRTLRKLVLNGCIDLTDSMIING 417

  Fly   525 VELIAENLQKLRALDLSWCPRITDASLEYI--ACDLNQLEELTLDRCVHITDIGVGYISTMLSLT 587
            :.........|..|.|....:||..||.|.  ..:||.|.|.:..||:.:.|:.:  |..:|:..
Yeast   418 LTAFIPEKCPLEVLSLEESDQITTDSLSYFFSKVELNNLIECSFRRCLQLGDMAI--IELLLNGA 480

  Fly   588 ALFLRWCSQVRDFGLQHLCSMRNLQVLSLAGCPLLTSSGL-------SSLIQLRHLQELELT 642
            .      ..:|...|..|..:.....::|| ||.||...|       .|:||:...|...||
Yeast   481 R------DSLRSLNLNSLKELTKEAFVALA-CPNLTYLDLGFVRCVDDSVIQMLGEQNPNLT 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	3/5 (60%)
		AMN1	383..600	CDD:187754	58/271 (21%)
		leucine-rich repeat	431..456	CDD:275381	7/24 (29%)
		leucine-rich repeat	457..482	CDD:275381	7/81 (9%)
		leucine-rich repeat	483..508	CDD:275381	4/24 (17%)
		leucine-rich repeat	509..534	CDD:275381	9/28 (32%)
		leucine-rich repeat	535..560	CDD:275381	9/26 (35%)
		leucine-rich repeat	561..585	CDD:275381	6/23 (26%)
		leucine-rich repeat	586..610	CDD:275381	3/23 (13%)
		leucine-rich repeat	636..661	CDD:275381	3/7 (43%)
RAD7	NP_012586.1	AMN1	228..440	CDD:187754	40/211 (19%)
		leucine-rich repeat	236..261	CDD:275381	4/24 (17%)
		leucine-rich repeat	262..287	CDD:275381	7/24 (29%)
		leucine-rich repeat	288..340	CDD:275381	6/51 (12%)
		leucine-rich repeat	342..365	CDD:275381	1/22 (5%)
		leucine-rich repeat	368..397	CDD:275381	6/28 (21%)
		leucine-rich repeat	398..426	CDD:275381	9/27 (33%)
		leucine-rich repeat	428..455	CDD:275381	9/26 (35%)
		leucine-rich repeat	456..475	CDD:275381	6/20 (30%)
		leucine-rich repeat	484..507	CDD:275381	6/23 (26%)
		leucine-rich repeat	508..533	CDD:275381	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I1756
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950