DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and KDM2B

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_011537169.1	Gene:	KDM2B / 84678	HGNCID:	13610	Length:	1353	Species:	Homo sapiens

Alignment Length:	688	Identity:	146/688 - (21%)
Similarity:	232/688 - (33%)	Gaps:	200/688 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RASAELSKRI--NGL--------GLRSKHHHS--------------STSSGAGGAGDAASPAGAT 52
            |.|.|.||::  :||        .||.|..:.              .||.|:........|.|::
Human   779 RRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSS 843

  Fly    53 PTPAAPSGKTSVMERVTNALCGGGNSNSNSGSNSSNSNTSSASATAATSPASNANPP-------- 109
            .:|...|..|...:::            ..|...........|...|....:.||.|
Human   844 LSPWWRSSLTYFQQQL------------KPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEP 896

  Fly   110 --QTPDKP--------SRGSSPSPG----GITMPGGQSQVQNSTHHLLQQQQQQQQHMQLQQSQQ 160
              :.|:.|        ||.|||:.|    |...|..:.:|:......|..::..:   :|.:...
Human   897 EDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSR---ELSKELN 958

  Fly   161 QHLQLQASTLINSNHHVMVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGM 225
            ..:|...::|.|.|...:.......|.....||                  |:......||
Human   959 HEIQRTENSLANENQQPIKSEPESEGEEPKRPP------------------GICERPHRFS---- 1001

  Fly   226 VAAQKAAASAGGTPLQLRKQLPNPHLHHPYGSMGINAASPLIM--------QHQLHPPPIH-SIE 281
                   ....|||.:||.|| .|.|..|  ...|:...|.:.        :|.:.||||. ..:
Human  1002 -------KGLNGTPRELRHQL-GPSLRSP--PRVISRPPPSVSPPKCIQMERHVIRPPPISPPPD 1056

  Fly   282 QLMLDD---RFLSR-----FFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQM 338
            .|.|||   ..:.|     .|.|.|..:..:..:||..| :......|.|: .:....|:.:..:
Human  1057 SLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTW-NRWCCDKRLWT-RIDLNHCKSITPL 1119

  Fly   339 PGCDRGKLYNSLIRRGFHALGLVGASDEDALDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDH 403
                   :.:.:|||.                     |:      ||.|..::||.:.|..|::.
Human  1120 -------MLSGIIRRQ---------------------PV------SLDLSWTNISKKQLSWLINR 1150

  Fly   404 LQSLFELELAGCNEVTEAGLWACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVT 468
            |..|.:|.|:||:.:..:.|.:...|.:.:|.:.....:.|      ||:...|..       .|
Human  1151 LPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKD------AQMRDLLSP-------PT 1202

  Fly   469 DAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAENLQ 533
            |.     .|.|..:.|.||             |||.       |.|:|.. :||..:.||..::.
Human  1203 DN-----RPGQMDNRSKLR-------------NIVE-------LRLAGLD-ITDASLRLIIRHMP 1241

  Fly   534 KLRALDLSWCPRITDASLEYIAC----DLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLRWC 594
            .|..|.||:|..:||.|:..:..    ..:.|.|:.|..|..:||..:.:.....::..:.||:|
Human  1242 LLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYC 1306

  Fly   595 SQVRDFGL-QHLCSMRNLQV----------LSLAGCPL 621
            .||...|. |.:..|.:.:.          |.|.|.||
Human  1307 KQVTKEGCEQFIAEMSDEESIQKINPSKPGLHLPGSPL 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	8/23 (35%)
		AMN1	383..600	CDD:187754	56/220 (25%)
		leucine-rich repeat	431..456	CDD:275381	4/24 (17%)
		leucine-rich repeat	457..482	CDD:275381	5/24 (21%)
		leucine-rich repeat	483..508	CDD:275381	6/24 (25%)
		leucine-rich repeat	509..534	CDD:275381	7/24 (29%)
		leucine-rich repeat	535..560	CDD:275381	8/28 (29%)
		leucine-rich repeat	561..585	CDD:275381	6/23 (26%)
		leucine-rich repeat	586..610	CDD:275381	8/24 (33%)
		leucine-rich repeat	636..661	CDD:275381
KDM2B	XP_011537169.1	JmjC	182..257	CDD:214721
		cupin_like	229..335	CDD:304367
		zf-CXXC	<615..651	CDD:251032
		PHD_KDM2B	661..722	CDD:277114
		F-box-like	1071..1111	CDD:289689	8/41 (20%)
		leucine-rich repeat	1105..1129	CDD:275381	5/52 (10%)
		AMN1	1121..1310	CDD:187754	59/254 (23%)
		leucine-rich repeat	1130..1153	CDD:275381	8/28 (29%)
		leucine-rich repeat	1154..1177	CDD:275381	6/22 (27%)
		leucine-rich repeat	1178..1217	CDD:275381	12/69 (17%)
		leucine-rich repeat	1218..1242	CDD:275381	9/31 (29%)
		leucine-rich repeat	1243..1272	CDD:275381	8/28 (29%)
		leucine-rich repeat	1273..1297	CDD:275381	6/23 (26%)
		leucine-rich repeat	1298..1323	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810