DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32085 and AFB4

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_567702.2	Gene:	AFB4 / 828541	AraportID:	AT4G24390	Length:	623	Species:	Arabidopsis thaliana

Alignment Length:	683	Identity:	130/683 - (19%)
Similarity:	220/683 - (32%)	Gaps:	250/683 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 NSNTSSASATAATSPASN--ANPPQTPDKPSRGSSPSPGGITMPGGQSQVQNSTHHLLQQQQQQQ 150
            :|::||:||...|:.:.|  ::||..||                   ..::|...::||....:.
plant    25 SSSSSSSSAATFTNKSRNFKSSPPPCPD-------------------HVLENVLENVLQFLTSRC 70

  Fly   151 QHMQLQQSQQQHLQLQASTLINSNHHVMVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNP 215
            ....:....:...:::|.|.:    .|.:|..      ....|...:....:..::.:.|   .|
plant    71 DRNAVSLVCRSWYRVEAQTRL----EVFIGNC------YSLSPARLIHRFKRVRSLVLKG---KP 122

  Fly   216 GSPTFSTM----GMVAAQKAAASAGGTPLQLRKQLPNPHLHHPYGSMGINAASPLIMQHQLHPPP 276
            ....|:.|    |...:...||:|...|     .|...||
plant   123 RFADFNLMPPNWGAQFSPWVAATAKAYP-----WLEKVHL------------------------- 157

  Fly   277 IHSIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGL-LPTLQCRELRQMPG 340
                :::.:.|..|:...:.|..::.  |..||.:...|        ||: :...:||:|:
plant   158 ----KRMFVTDDDLALLAESFPGFKE--LTLVCCEGFGT--------SGIAIVANKCRQLK---- 204

  Fly   341 CDRGKLYNSLIRRGFHALGLVGAS-DEDALDVVHSFPLASKHVHSLSLRC--SSISDRGLETLL- 401
                            .|.|:.:. .:|.||.:..||....|:.|||..|  |.|:.:.||.|:
plant   205 ----------------VLDLMESEVTDDELDWISCFPEGETHLESLSFDCVESPINFKALEELVV 253

  Fly   402 ----------DHLQSLFELE-------------------------------------------LA 413
                      :...||.||.                                           |:
plant   254 RSPFLKKLRTNRFVSLEELHRLMVRAPQLTSLGTGSFSPDNVPQGEQQPDYAAAFRACKSIVCLS 318

  Fly   414 G---------------CNEVTEAGL-WACLTPRIVSLSLADCIN---------IADEAVGAVAQL 453
            |               |..:|.... :|.::|.::...:::|.|         |.||.:.|||..
plant   319 GFREFRPEYLLAISSVCANLTSLNFSYANISPHMLKPIISNCHNIRVFWALDSIRDEGLQAVAAT 383

  Fly   454 LPSLYEFSLQAYHVTDAALGYFS--PKQSHSLSILRLQS----CWELTNHGIVNIVHSLPHLTVL 512
            ...|.|..:..:...:.:.|..|  ..|:.|....:|:|    |..:||..:..:..:.|.|||.
plant   384 CKELRELRIFPFDPREDSEGPVSGVGLQAISEGCRKLESILYFCQNMTNGAVTAMSENCPQLTVF 448

  Fly   513 SLSGC-----------SKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTL 566
            .|  |           .|..|||...|.:|.:||..|.:|..  :||.:..||. :..:|
plant   449 RL--CIMGRHRPDHVTGKPMDDGFGAIVKNCKKLTRLAVSGL--LTDEAFSYIG-EYGKL----- 503

  Fly   567 DRCVHITDIGVGYISTMLSLTALFLRWCSQVR----------DFGLQ---HLCSMRNLQVLSLAG 618
                 |..:.|.:...........|..|.:::          |.||:   |..|  |::.:.|:.
plant   504 -----IRTLSVAFAGNSDKALRYVLEGCPKLQKLEIRDSPFGDVGLRSGMHRYS--NMRFVWLSS 561

  Fly   619 CPLLTSSGLSSLIQLRHLQELELTNCPGASHEL 651
            |  |.|.|                .|.|.||.|
plant   562 C--LISRG----------------GCRGVSHAL 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	9/36 (25%)
		AMN1	383..600	CDD:187754	63/324 (19%)
		leucine-rich repeat	431..456	CDD:275381	8/33 (24%)
		leucine-rich repeat	457..482	CDD:275381	5/26 (19%)
		leucine-rich repeat	483..508	CDD:275381	5/28 (18%)
		leucine-rich repeat	509..534	CDD:275381	11/35 (31%)
		leucine-rich repeat	535..560	CDD:275381	7/24 (29%)
		leucine-rich repeat	561..585	CDD:275381	3/23 (13%)
		leucine-rich repeat	586..610	CDD:275381	7/36 (19%)
		leucine-rich repeat	636..661	CDD:275381	5/16 (31%)
AFB4	NP_567702.2	F-box_5	51..90	CDD:375937	6/57 (11%)
		Transp_inhibit	112..157	CDD:376210	10/52 (19%)
		leucine-rich repeat	152..176	CDD:275381	6/52 (12%)
		AMN1	<162..>283	CDD:187754	33/150 (22%)
		leucine-rich repeat	177..202	CDD:275381	7/34 (21%)
		leucine-rich repeat	203..257	CDD:275381	18/73 (25%)
		leucine-rich repeat	258..330	CDD:275381	6/71 (8%)
		leucine-rich repeat	338..362	CDD:275381	4/23 (17%)
		leucine-rich repeat	363..386	CDD:275381	6/22 (27%)
		AMN1	<384..538	CDD:187754	36/168 (21%)
		leucine-rich repeat	387..419	CDD:275381	6/31 (19%)
		leucine-rich repeat	420..444	CDD:275381	5/23 (22%)
		leucine-rich repeat	445..479	CDD:275381	11/35 (31%)
		leucine-rich repeat	480..503	CDD:275381	7/25 (28%)
		leucine-rich repeat	504..528	CDD:275381	4/23 (17%)
		leucine-rich repeat	529..553	CDD:275381	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820