DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and fbxl16

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001188265.1	Gene:	fbxl16 / 797939	ZFINID:	ZDB-GENE-120215-180	Length:	493	Species:	Danio rerio

Alignment Length:	488	Identity:	253/488 - (51%)
Similarity:	327/488 - (67%)	Gaps:	61/488 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAASAGGTPLQLRKQLP 247
            ||..:|....|.||..|:......|.|...:.|                       ||   :|.|
Zfish    63 PPPSLPYHLDPLPTAASLLGPDLDTSPVTAIKP-----------------------PL---RQFP 101

  Fly   248 NPHLHHPYGSMGINAASPLIMQHQLHPPPIHSIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKW 312
            .|.|.                            .||:||::.|:|...||:..|:.||||||..|
Zfish   102 KPLLE----------------------------RQLILDEKVLNRLLWYFTTAEKCILAQVCKTW 138

  Fly   313 RDTLYRSPRYWSGLLPTLQCRELRQ-MPGCDRGKLYNSL---IRRGFHALGLVGASDEDALDVVH 373
            |..||: |::|.|:.|.|..:||.. :|..:  |.:.||   ..|||.|..|||.||.|..:.:.
Zfish   139 RKVLYQ-PKFWEGVTPILHAKELYTILPNGE--KEFVSLQAFALRGFQAFCLVGVSDLDICEFID 200

  Fly   374 SFPLASKHVHSLSLRCSSISDRGLETLLDHLQSLFELELAGCNEVTEAGLWACLTPRIVSLSLAD 438
            ::||:.|.|.|:||:.|:|:|.|||.:|:.:|.|..|||:|||:.||||||:.|..|:.|||::|
Zfish   201 NYPLSKKGVKSVSLKRSTITDAGLEVMLEQMQGLMHLELSGCNDFTEAGLWSSLNARLTSLSVSD 265

  Fly   439 CINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIV 503
            |||:||:|:.|::||||:|.|.|||||||||.|:.||:.||.::...|||.||||:||||:||:|
Zfish   266 CINVADDAIAAISQLLPNLSELSLQAYHVTDTAMAYFTAKQGYTTHTLRLNSCWEITNHGVVNMV 330

  Fly   504 HSLPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDR 568
            ||||:||.||||||||:|||||||:||||:|||:|||||||||||.:||||||||::||||.|||
Zfish   331 HSLPNLTSLSLSGCSKITDDGVELVAENLRKLRSLDLSWCPRITDMALEYIACDLHKLEELVLDR 395

  Fly   569 CVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHLCSMRNLQVLSLAGCPLLTSSGLSSLIQL 633
            ||.|||.|:||:|||.:|.:|:||||.||:|||||||..||:|::||||||||||::|||.||||
Zfish   396 CVRITDTGLGYLSTMSTLRSLYLRWCCQVQDFGLQHLYGMRSLRLLSLAGCPLLTTTGLSGLIQL 460

  Fly   634 RHLQELELTNCPGASHELFDYLKEHLPRCLIIE 666
            :.|:||||||||||:.|||.|..:|||||::||
Zfish   461 QDLEELELTNCPGATAELFKYYSQHLPRCMVIE 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	11/23 (48%)
		AMN1	383..600	CDD:187754	144/216 (67%)
		leucine-rich repeat	431..456	CDD:275381	14/24 (58%)
		leucine-rich repeat	457..482	CDD:275381	16/24 (67%)
		leucine-rich repeat	483..508	CDD:275381	17/24 (71%)
		leucine-rich repeat	509..534	CDD:275381	21/24 (88%)
		leucine-rich repeat	535..560	CDD:275381	21/24 (88%)
		leucine-rich repeat	561..585	CDD:275381	18/23 (78%)
		leucine-rich repeat	586..610	CDD:275381	16/23 (70%)
		leucine-rich repeat	636..661	CDD:275381	17/24 (71%)
fbxl16	NP_001188265.1	leucine-rich repeat	209..233	CDD:275381	11/23 (48%)
		AMN1	215..446	CDD:187754	155/230 (67%)
		leucine-rich repeat	234..253	CDD:275381	13/18 (72%)
		leucine-rich repeat	258..283	CDD:275381	14/24 (58%)
		leucine-rich repeat	284..308	CDD:275381	16/23 (70%)
		leucine-rich repeat	309..335	CDD:275381	17/25 (68%)
		leucine-rich repeat	336..361	CDD:275381	21/24 (88%)
		leucine-rich repeat	362..387	CDD:275381	21/24 (88%)
		leucine-rich repeat	388..412	CDD:275381	18/23 (78%)
		leucine-rich repeat	413..437	CDD:275381	16/23 (70%)
		leucine-rich repeat	438..457	CDD:275381	14/18 (78%)
		leucine-rich repeat	463..488	CDD:275381	17/24 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575143
Domainoid	1	1.000	171	1.000	Domainoid score	I3720
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H17732
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1394
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	1	1.000	-	-		FOG0006549
OrthoInspector	1	1.000	-	-		oto40990
orthoMCL	1	0.900	-	-		OOG6_109702
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5643
SonicParanoid	1	1.000	-	-		X5541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930