DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32085 and amn1

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001038919.1	Gene:	amn1 / 751744	ZFINID:	ZDB-GENE-060825-13	Length:	249	Species:	Danio rerio

Alignment Length:	257	Identity:	67/257 - (26%)
Similarity:	121/257 - (47%)	Gaps:	28/257 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 LDHLQSLFELELAGCNEVTEAGLWACLTPRIVSLSLADCINIADEAVGAV-----AQLLPS-LYE 459
            :|.|.||....:|...|..|       ..|::..|:.|.:.....:.|.|     :||:.| .:.
Zfish     4 IDSLMSLCAFSVAQRAEKYE-------DIRMLPASVKDRLLRIMTSYGTVTDSNISQLVHSGTHT 61

  Fly   460 FSLQAYHVTDAALGYFSPKQSHSLSI--LRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTD 522
            ..||...::|:||     ||.:||.:  :.|:.|.|:|:.|:..:....|:|.|:.|:||:.:||
Zfish    62 LDLQNCKISDSAL-----KQINSLHLRTILLRGCAEITSEGLEVLAPRCPYLQVVDLTGCTAVTD 121

  Fly   523 DGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYIST---ML 584
            .|::.:|.:.:.|..:.|..|..::|.:|..:..:...|..:.... ..:||.||..::|   ..
Zfish   122 SGIQALARHCKCLEVISLRGCSALSDKALLELGGNCKMLHSIYFSG-TEVTDQGVIGLATGVCSC 185

  Fly   585 SLTALFLRWCSQVRDFGLQH-LCSMRNLQVLSLAGCPLLTS---SGLSSLIQLRHLQELELT 642
            ||..|.:..|..:.|..:.. |.:..|:::.:..||||:|.   ..|.:||....:|::..|
Zfish   186 SLKELQMVRCRNLTDLAVTAVLTNCANIRIFNFHGCPLITDKSREALQNLIGPNKIQQVSWT 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	2/4 (50%)
		AMN1	383..600	CDD:187754	54/209 (26%)
		leucine-rich repeat	431..456	CDD:275381	6/29 (21%)
		leucine-rich repeat	457..482	CDD:275381	7/24 (29%)
		leucine-rich repeat	483..508	CDD:275381	6/26 (23%)
		leucine-rich repeat	509..534	CDD:275381	9/24 (38%)
		leucine-rich repeat	535..560	CDD:275381	5/24 (21%)
		leucine-rich repeat	561..585	CDD:275381	6/26 (23%)
		leucine-rich repeat	586..610	CDD:275381	5/24 (21%)
		leucine-rich repeat	636..661	CDD:275381	2/7 (29%)
amn1	NP_001038919.1	AMN1	33..248	CDD:187754	58/221 (26%)
		leucine-rich repeat	59..72	CDD:275381	2/12 (17%)
		leucine-rich repeat	82..107	CDD:275381	5/24 (21%)
		leucine-rich repeat	108..133	CDD:275381	9/24 (38%)
		leucine-rich repeat	134..159	CDD:275381	5/24 (21%)
		leucine-rich repeat	160..186	CDD:275381	6/26 (23%)
		leucine-rich repeat	187..212	CDD:275381	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900