DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32085 and FBXL17

DIOPT Version :9

Sequence 1:NP_729732.1 Gene:CG32085 / 39311 FlyBaseID:FBgn0052085 Length:666 Species:Drosophila melanogaster
Sequence 2:XP_005272105.1 Gene:FBXL17 / 64839 HGNCID:13615 Length:712 Species:Homo sapiens


Alignment Length:691 Identity:155/691 - (22%)
Similarity:226/691 - (32%) Gaps:235/691 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SSTSSGAGGAGDAASPA------------------------------------------GATPTP 55
            ||.::.|..|..|:|||                                          |.||:|
Human   122 SSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLFLASLGPVRFLGPPAAVQLFRGPTPSP 186

  Fly    56 A-APSGKTSVMER----------VTNALCGGGNSNSNSGSNSSNSNTSSASATAATSPA-SNANP 108
            | .|:....|.:|          .....||||......|.....            .|| ..|:|
Human   187 AELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGG------------GPAGGGASP 239

  Fly   109 PQTPDKPSRGSSPSPGGITMPGGQSQVQNSTHHLLQQQQQQQQHMQLQQSQQQHLQLQASTLINS 173
            |:.||   .|...:|                                                  
Human   240 PRPPD---AGCCQAP-------------------------------------------------- 251

  Fly   174 NHHVMVGPAPPTGMPLGAPP-TPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAASAGG 237
                   ..||  .||..|| :||                 :.|:||       .|...|..|||
Human   252 -------EQPP--QPLCPPPSSPT-----------------SEGAPT-------EAGGDAVRAGG 283

  Fly   238 T-PLQLRKQ-----------LPNP---HLHHPYGSMGINAASPLIMQHQLHPPPIHSIEQLMLDD 287
            | ||..::|           ..||   |...|..:..||...|.|:        :.....|.||:
Human   284 TAPLSAQQQHECGDADCRESPENPCDCHREPPPETPDINQLPPSIL--------LKIFSNLSLDE 340

  Fly   288 RFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGL-LPTLQ-------------------- 331
            |.||             .:.||..||| |....::|..| |.:.|                    
Human   341 RCLS-------------ASLVCKYWRD-LCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEI 391

  Fly   332 ----CRELRQMPGCDRGKLYNSLIRRGFHALGLVGASDEDALDVVHSFPLASK-HVHSLSLRCSS 391
                ||.:.....|........|:|  :.|......||...:.|....||..| ||.:.    ..
Human   392 NISDCRSMSDNGVCVLAFKCPGLLR--YTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQ----DK 450

  Fly   392 ISDRGLETLLDHLQSLFELELAGCNEVTEAGL----WACLTPRIVSLSLADCINIADEAVGAVAQ 452
            ::|.||:.|....:.|.::....|.::::.|:    ..||  ::..:.:.:...:.|::|.|.|:
Human   451 LTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCL--KLQRIYMQENKLVTDQSVKAFAE 513

  Fly   453 LLPSLYEFSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGC 517
            ..|.|.........||  :.|.....:..:||.|.|:...||.|..::.||....:|:.|:|...
Human   514 HCPELQYVGFMGCSVT--SKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLN 576

  Fly   518 SKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYIS- 581
            ..:.|..||:||:..|.|:.|.|..| :|||.:|..|......:|.:.:..|..|||.|...|: 
Human   577 WIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQ 640

  Fly   582 TMLSLTALFLRWCSQVR-DFGLQHLCSMRNLQVLSLAGCPL 621
            :..||..|.|..|.:|| |:  |.:|.:....|.||...||
Human   641 SSKSLRYLGLMRCDKVRVDY--QVVCFLHISIVNSLMSYPL 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32085NP_729732.1 leucine-rich repeat 382..406 CDD:275381 5/23 (22%)
AMN1 383..600 CDD:187754 59/222 (27%)
leucine-rich repeat 431..456 CDD:275381 4/24 (17%)
leucine-rich repeat 457..482 CDD:275381 4/24 (17%)
leucine-rich repeat 483..508 CDD:275381 9/24 (38%)
leucine-rich repeat 509..534 CDD:275381 8/24 (33%)
leucine-rich repeat 535..560 CDD:275381 9/24 (38%)
leucine-rich repeat 561..585 CDD:275381 7/24 (29%)
leucine-rich repeat 586..610 CDD:275381 9/24 (38%)
leucine-rich repeat 636..661 CDD:275381
FBXL17XP_005272105.1 F-box-like 321..368 CDD:289689 18/68 (26%)
leucine-rich repeat 362..387 CDD:275381 4/24 (17%)
leucine-rich repeat 388..413 CDD:275381 3/24 (13%)
AMN1 411..573 CDD:187754 40/171 (23%)
leucine-rich repeat 414..439 CDD:275381 6/26 (23%)
leucine-rich repeat 440..465 CDD:275381 7/28 (25%)
leucine-rich repeat 466..491 CDD:275381 5/26 (19%)
leucine-rich repeat 492..517 CDD:275381 4/24 (17%)
leucine-rich repeat 518..541 CDD:275381 4/24 (17%)
leucine-rich repeat 542..567 CDD:275381 9/24 (38%)
AMN1 547..>652 CDD:187754 35/105 (33%)
leucine-rich repeat 568..593 CDD:275381 8/24 (33%)
leucine-rich repeat 594..615 CDD:275381 9/21 (43%)
leucine-rich repeat 619..641 CDD:275381 7/21 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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