DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32085 and FBXL19

DIOPT Version :9

Sequence 1:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001093254.2	Gene:	FBXL19 / 54620	HGNCID:	25300	Length:	694	Species:	Homo sapiens

Alignment Length:	587	Identity:	128/587 - (21%)
Similarity:	194/587 - (33%)	Gaps:	204/587 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AASPAGATPTPAAPSGKTSVMERVTNALCGGGNSNSNSGSNSSNSNTSSASATAATSPASNANPP 109
            |::...|.|:|:....|....:|:...|....:::|:|..:.|:|::|..|.:...:|....|
Human   290 ASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARN-- 352

  Fly   110 QTPDKPSRGSSPSPGGITMPGGQSQVQ-NSTHHLLQQQQQQQQHMQLQQSQQQHLQLQASTLINS 173
              ..:|:||||   |.....||:..|: .|...||...
Human   353 --GRRPARGSS---GEKENRGGRRAVRPGSGGPLLSWP--------------------------- 385

  Fly   174 NHHVMVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAASAGGT 238
                 :|||||       |..|.:     :.::..|    .|.||...|:.:.|...
Human   386 -----LGPAPP-------PRPPQL-----ERHVVRP----PPRSPEPDTLPLAAGSD-------- 421

  Fly   239 PLQLRKQLPNPHLHHPYGSMGINAASPLIMQHQLHPPPIHSIEQLMLDDRFLSRFFQYFSPYERR 303
                                              ||.|..:          ..|.||:..|.|..
Human   422 ----------------------------------HPLPRAA----------WLRVFQHLGPRELC 442

  Fly   304 ILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALGLVGASDEDA 368
            |..:||..|        ..|        |.:.|..|..|..:      |:......|.|
Human   443 ICMRVCRTW--------SRW--------CYDKRLWPRMDLSR------RKSLTPPMLSG------ 479

  Fly   369 LDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQSLFELELAGCNEVTEAGLWACLTPRIVS 433
              ||...|.|      |.|..:.:|.:.|..||:.||.|.||.|:||:.::.:.|.:...|.:..
Human   480 --VVRRQPRA------LDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRL 536

  Fly   434 LSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHG 498
            |.|....::.|..:..:  |||.           .|.     .|.|:.|..  |||...||...|
Human   537 LDLRWIEDVKDSQLREL--LLPP-----------PDT-----KPGQTESRG--RLQGVAELRLAG 581

  Fly   499 IVNIVHSLPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEE 563
            :                   :|||..:.|:..:..:|.|||||.|..:.|.|:..:....:.|.|
Human   582 L-------------------ELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRE 627

  Fly   564 ----LTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHLCSMRNLQVLSLAGCPLLTS 624
                |.|..|..:||          ....||.| |.::|...|      |:.:.||...|..|.:
Human   628 TLVHLNLAGCHRLTD----------HCLPLFRR-CPRLRRLDL------RSCRQLSPEACARLAA 675

  Fly   625 SG 626
            :|
Human   676 AG 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	7/23 (30%)
		AMN1	383..600	CDD:187754	57/220 (26%)
		leucine-rich repeat	431..456	CDD:275381	5/24 (21%)
		leucine-rich repeat	457..482	CDD:275381	3/24 (13%)
		leucine-rich repeat	483..508	CDD:275381	6/24 (25%)
		leucine-rich repeat	509..534	CDD:275381	4/24 (17%)
		leucine-rich repeat	535..560	CDD:275381	9/24 (38%)
		leucine-rich repeat	561..585	CDD:275381	7/27 (26%)
		leucine-rich repeat	586..610	CDD:275381	6/23 (26%)
		leucine-rich repeat	636..661	CDD:275381
FBXL19	NP_001093254.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-CXXC	<50..77	CDD:251032
		PHD_FXL19	87..148	CDD:277115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..420		40/184 (22%)
		F-box-like	424..465	CDD:315592	14/66 (21%)
		leucine-rich repeat	461..485	CDD:275381	7/37 (19%)
		AMN1	466..665	CDD:332986	66/274 (24%)
		leucine-rich repeat	486..508	CDD:275381	7/27 (26%)
		LRR 1	492..517		10/24 (42%)
		leucine-rich repeat	510..533	CDD:275381	7/22 (32%)
		LRR 2	518..541		5/22 (23%)
		leucine-rich repeat	534..573	CDD:275381	12/58 (21%)
		leucine-rich repeat	574..598	CDD:275381	7/42 (17%)
		LRR 3	581..606		10/43 (23%)
		leucine-rich repeat	599..623	CDD:275381	9/23 (39%)
		LRR 4	607..636		7/28 (25%)
		leucine-rich repeat	629..653	CDD:275381	9/34 (26%)
		LRR 5	637..661		9/40 (23%)
		leucine-rich repeat	654..686	CDD:275381	8/30 (27%)
		LRR 6	662..694		5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910